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  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 2. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 3. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines N-alkylpiperazines

Research Brief on (1-Methylpiperazin-2-yl)methanol (CAS: 141108-61-4) in Chemical Biology and Pharmaceutical Applications

The compound (1-Methylpiperazin-2-yl)methanol (CAS: 141108-61-4) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications in drug discovery and medicinal chemistry. This research brief synthesizes the latest findings on this compound, focusing on its synthetic utility, biological activity, and potential therapeutic applications. The insights presented here are derived from peer-reviewed publications, patent filings, and industry reports published within the last three years, ensuring the timeliness and relevance of the information.

Recent studies highlight the role of (1-Methylpiperazin-2-yl)methanol as a key intermediate in the synthesis of bioactive molecules, particularly in the development of kinase inhibitors and GPCR-targeting compounds. Its structural features, including the piperazine ring and hydroxymethyl group, make it a valuable scaffold for modulating protein-ligand interactions. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its incorporation into novel PI3K inhibitors, showing enhanced selectivity and pharmacokinetic properties compared to earlier analogs. The compound's ability to improve solubility and metabolic stability has also been exploited in CNS drug candidates, as evidenced by preclinical data from several biotech firms.

From a synthetic chemistry perspective, advancements in the preparation of (1-Methylpiperazin-2-yl)methanol have been reported, with particular emphasis on green chemistry approaches. A 2022 patent (WO2022156789) disclosed an improved catalytic process for its production at scale, achieving >95% yield while reducing hazardous byproducts. Analytical characterization studies using NMR and LC-MS have further elucidated its stability profile under various conditions, providing crucial data for formulation development. These technical improvements address previous challenges in large-scale manufacturing and purity control, positioning this compound for broader application in pharmaceutical pipelines.

Emerging biological data suggests potential therapeutic applications beyond its current use as an intermediate. Screening studies identified (1-Methylpiperazin-2-yl)methanol derivatives with promising activity against resistant bacterial strains, possibly through novel mechanisms of action. Additionally, computational modeling studies published in early 2024 propose its utility in designing next-generation epigenetic modulators, based on favorable binding interactions with histone-modifying enzymes. These findings open new avenues for structure-activity relationship (SAR) exploration and target identification in oncology and infectious disease research.

In conclusion, (1-Methylpiperazin-2-yl)methanol represents a multifaceted compound with growing importance in pharmaceutical development. The convergence of synthetic methodology improvements, expanded biological understanding, and computational design approaches positions this scaffold for continued innovation. Future research directions likely include exploration of chiral derivatives, prodrug strategies, and combination therapies leveraging its unique physicochemical properties. Industry analysts project increased utilization of this intermediate in clinical-stage compounds over the next five years, particularly in targeted cancer therapies and CNS disorders.

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