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  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Aminopyrimidines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Aminopyrimidines and derivatives

N-Cyclohexylpyrimidin-2-Amine: A Comprehensive Overview

N-cyclohexylpyrimidin-2-amine is a versatile organic compound with the CAS registry number 14080-24-1. This compound has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science due to its unique structural properties and potential applications. The molecule consists of a pyrimidine ring, a nitrogen-containing heterocycle, substituted with a cyclohexyl group at the 2-position. This substitution imparts unique electronic and steric properties, making it a valuable building block in various chemical reactions and drug discovery programs.

Recent advancements in synthetic methodologies have enabled the efficient synthesis of N-cyclohexylpyrimidin-2-amine, leveraging both traditional and modern techniques. Researchers have explored various routes, including nucleophilic aromatic substitution, condensation reactions, and transition-metal-catalyzed coupling reactions. These methods not only enhance the scalability of production but also allow for fine-tuning of the compound's properties to suit specific applications.

The structural versatility of N-cyclohexylpyrimidin-2-amine has been exploited in the development of novel pharmaceutical agents. For instance, studies have demonstrated its potential as a kinase inhibitor, targeting key enzymes involved in cellular signaling pathways. This makes it a promising candidate for anti-cancer therapies, where modulation of kinase activity is crucial for inhibiting tumor growth and metastasis.

In addition to its pharmacological applications, N-cyclohexylpyrimidin-2-amine has found utility in materials science. Its ability to form stable coordination complexes with metal ions has led to its use in the synthesis of metal-organic frameworks (MOFs) and other porous materials. These materials exhibit exceptional gas adsorption capabilities, making them ideal for applications in gas storage and separation technologies.

Recent research has also highlighted the role of N-cyclohexylpyrimidin-2-amine as a precursor for advanced materials with tailored electronic properties. By incorporating this compound into conjugated systems, scientists have developed materials with enhanced conductivity and optical properties, paving the way for applications in organic electronics and optoelectronics.

The toxicity profile of N-cyclohexylpyrimidin-2-amine has been extensively studied to ensure its safe handling and application in biomedical contexts. Preclinical studies indicate that the compound exhibits low toxicity at therapeutic concentrations, making it a favorable candidate for further clinical evaluation.

As interest in N-cyclohexylpyrimidin-2-amine continues to grow, ongoing research is focused on expanding its functionalization possibilities and exploring its interactions with biological systems. Collaborative efforts between chemists, biologists, and materials scientists are expected to unlock new avenues for its application across diverse fields.

In conclusion, N-cyclohexylpyrimidin-2-amine stands as a testament to the power of chemical innovation in addressing complex scientific challenges. Its unique properties, coupled with ongoing advancements in synthetic and applied research, position it as a key player in the development of next-generation pharmaceuticals and advanced materials.

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• 10132-28-2(N-butylpyrimidin-2-amine)
• 63260-58-2(N-(piperidin-4-yl)pyrimidin-2-amine dihydrochloride)
• 151390-00-0(N-cyclopropylpyrimidin-2-amine)
• 151390-02-2(N-cyclobutylpyrimidin-2-amine)
• 1010422-34-0(N-cyclobutyl-n-methylpyrimidin-2-amine)
• 14095-75-1(2-Pyrimidinamine, N-pentyl-)
• 141193-13-7(N-cyclohexyl-N-methylpyrimidin-2-amine)