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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Overview of tert-butyl (2R)-piperidine-2-carboxylate (CAS No. 140646-13-5): Properties, Applications, and Industry Insights

The compound tert-butyl (2R)-piperidine-2-carboxylate (CAS No. 140646-13-5) is a chiral intermediate widely utilized in pharmaceutical synthesis and organic chemistry. Its structural uniqueness, characterized by the tert-butyl ester group and the (2R)-piperidine-2-carboxylate backbone, makes it a versatile building block for asymmetric synthesis. Researchers and manufacturers increasingly focus on this compound due to its role in producing enantiomerically pure APIs (Active Pharmaceutical Ingredients), aligning with the growing demand for precision medicine.

One of the most searched questions in AI-driven drug discovery platforms revolves around "chiral auxiliaries for asymmetric synthesis," where tert-butyl (2R)-piperidine-2-carboxylate stands out. Its stereochemical stability and compatibility with N-protecting groups make it ideal for constructing complex molecular architectures. Recent publications highlight its application in peptide mimetics and kinase inhibitor development, addressing trending topics like "targeted cancer therapies" and "neurodegenerative disease research."

From a technical perspective, the CAS No. 140646-13-5 compound exhibits excellent solubility in organic solvents such as dichloromethane and tetrahydrofuran, a feature frequently queried in chemical database searches. Its boiling point and storage conditions (typically under inert gas) are critical for industrial-scale handling, as emphasized in Good Manufacturing Practice (GMP) guidelines. These properties are often cross-referenced with green chemistry principles, another high-traffic keyword in modern synthetic chemistry discussions.

The pharmaceutical industry leverages this compound’s enantioselective properties to optimize drug efficacy while minimizing side effects—a priority in FDA approval processes. For instance, its derivatives appear in preclinical studies for G-protein-coupled receptor (GPCR) modulators, a hot topic in AI-based molecular modeling forums. Additionally, patent analyses reveal its utility in prodrug formulations, answering frequent queries about "controlled-release drug delivery systems."

In academic settings, tert-butyl (2R)-piperidine-2-carboxylate serves as a pedagogical tool for demonstrating stereocontrolled reactions. Laboratory supply vendors report increased searches for this compound paired with terms like "Schlenk technique" or "catalytic hydrogenation," reflecting its relevance in advanced organic chemistry curricula. Its NMR spectra (particularly ¹³C and ¹H signals) are also widely documented, supporting spectroscopic identification workflows.

Environmental and regulatory considerations further enhance its profile. Unlike some volatile intermediates, this compound’s low ecotoxicity aligns with REACH compliance standards—a frequent search criterion among EU-based manufacturers. Moreover, its solid-state stability at room temperature reduces logistical challenges, a practical advantage highlighted in supply chain optimization case studies.

Emerging applications include its use in metal-organic frameworks (MOFs) and catalysis, areas gaining traction in materials science communities. Computational chemists often model its conformational flexibility to design novel ligands, addressing queries like "molecular docking scaffolds." Such interdisciplinary relevance ensures sustained interest in CAS No. 140646-13-5 across biotech, nanotechnology, and academic research sectors.

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