• 1. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 3. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Tert-butyl (2R)-azepane-2-carboxylate: A Comprehensive Overview

The compound with CAS No. 431052-49-2, commonly referred to as tert-butyl (2R)-azepane-2-carboxylate, is a significant molecule in the field of organic chemistry and pharmaceutical research. This compound is a derivative of azepane, a seven-membered cyclic amine, and is characterized by its tert-butyl ester group and the specific stereochemistry at the second carbon atom, denoted by the (R) configuration. The molecule's structure makes it a versatile building block for various applications in drug discovery and chemical synthesis.

Recent advancements in chiral synthesis have highlighted the importance of tert-butyl (2R)-azepane-2-carboxylate in constructing complex molecular architectures. Researchers have employed this compound as a key intermediate in the synthesis of bioactive molecules, including potential drug candidates for treating neurological disorders and infectious diseases. Its unique stereochemistry allows for precise control over the spatial arrangement of substituents, which is crucial for optimizing pharmacokinetic properties such as bioavailability and metabolic stability.

The synthesis of tert-butyl (2R)-azepane-2-carboxylate typically involves multi-step processes that combine principles of stereochemistry and catalytic asymmetric synthesis. One notable approach involves the use of organocatalysts to induce high enantioselectivity during the formation of the azepane ring. This method not only enhances the efficiency of the synthesis but also aligns with current trends toward sustainable and environmentally friendly chemical processes.

In terms of applications, tert-butyl (2R)-azepane-2-carboxylate has shown promise in medicinal chemistry as a chiral auxiliary or a ligand in asymmetric catalysis. Its ability to participate in various coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, has made it a valuable tool for constructing diverse libraries of compounds with defined stereochemistry. Furthermore, its compatibility with common protecting group strategies enables its integration into larger synthetic frameworks.

Recent studies have also explored the use of tert-butyl (2R)-azepane-2-carboxylate in peptide synthesis and macrocycle formation. Its rigid cyclic structure provides stability to peptide backbones, making it an attractive option for designing cyclic peptides with enhanced bioactivity. Additionally, its role in forming macrocyclic compounds has opened new avenues for developing supramolecular assemblies with applications in drug delivery and materials science.

The pharmacological evaluation of derivatives derived from tert-butyl (2R)-azepane-2-carboxylate has revealed interesting biological activities. For instance, certain analogs have demonstrated potent inhibitory effects on enzymes involved in neurodegenerative diseases, such as beta-secretase. These findings underscore the potential of this compound as a lead structure for developing therapeutic agents targeting complex biological systems.

In conclusion, tert-butyl (2R)-azepane-2-carboxylate stands out as a pivotal molecule in contemporary organic chemistry and drug discovery. Its unique structural features, coupled with advancements in synthetic methodologies, position it as a valuable asset for constructing bioactive molecules with tailored properties. As research continues to uncover new applications and optimizations, this compound will likely play an increasingly important role in both academic and industrial settings.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)