• 1. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 2. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 3. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 4. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 5. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431

• Solvents and Organic Chemicals Organic Compounds Organosulfur compounds Thioethers Aryl thioethers

Professional Introduction to 2-(Ethylthio)aniline (CAS No. 13920-91-7)

2-(Ethylthio)aniline, with the chemical formula C₈H₁₁NS, is a significant compound in the field of organic chemistry and pharmaceutical research. Its CAS number, CAS No. 13920-91-7, uniquely identifies it in scientific literature and databases. This compound has garnered attention due to its versatile applications in synthesizing various pharmacologically active molecules. The ethylthio group attached to the aniline core introduces unique reactivity and binding properties, making it a valuable intermediate in drug development.

The structural characteristics of 2-(ethylthio)aniline contribute to its utility in medicinal chemistry. The presence of both aromatic and sulfur-containing moieties allows for diverse chemical modifications, enabling the design of molecules with tailored biological activities. Recent studies have highlighted its role in the synthesis of novel antimicrobial agents, where the ethylthio group enhances interaction with bacterial cell membranes, leading to improved efficacy.

In the realm of pharmaceutical innovation, 2-(ethylthio)aniline has been explored as a precursor for developing treatments against neurological disorders. Research indicates that derivatives of this compound exhibit potential neuroprotective properties by modulating neurotransmitter pathways. The sulfur atom in the ethylthio group facilitates interactions with specific enzymes and receptors, which are crucial for maintaining neuronal health. This discovery has spurred further investigation into its potential as a lead compound for therapies targeting neurodegenerative diseases.

The compound's reactivity also makes it a valuable tool in synthetic organic chemistry. It participates in various coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, which are pivotal for constructing complex molecular architectures. These reactions enable the formation of biaryl systems, which are prevalent in many bioactive molecules. The ability to seamlessly integrate 2-(ethylthio)aniline into larger frameworks underscores its importance as a building block in medicinal chemistry.

Advances in computational chemistry have further enhanced the understanding of 2-(ethylthio)aniline's properties. Molecular modeling studies have revealed insights into its binding affinity and interaction patterns with biological targets. These simulations have guided the optimization of analogs with improved pharmacokinetic profiles, reducing off-target effects while maintaining therapeutic efficacy. Such computational approaches are becoming increasingly integral to drug discovery pipelines, streamlining the identification of promising candidates.

The synthesis of 2-(ethylthio)aniline can be achieved through multiple routes, each offering distinct advantages depending on scalability and purity requirements. Traditional methods involve nucleophilic substitution reactions on aniline derivatives, while modern techniques employ transition metal-catalyzed processes for higher yields and selectivity. Recent innovations in green chemistry have also focused on developing eco-friendly synthetic pathways, minimizing waste and energy consumption without compromising product quality.

In conclusion, 2-(Ethylthio)aniline (CAS No. 13920-91-7) is a multifaceted compound with significant implications in pharmaceutical research and industrial applications. Its unique structural features enable diverse functionalization, making it a cornerstone in the development of novel therapeutic agents. As research continues to uncover new applications and synthetic strategies, this compound remains at the forefront of chemical innovation, driving advancements across multiple scientific disciplines.

• 52411-33-3(2-({2-(2-Aminophenyl)thioethyl}thio)aniline)
• 6397-33-7(2-(Isopropylthio)aniline)
• 79792-95-3(2-(propylthio)phenylamine hydrochloride)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)