Production Method 1

135-37-5

139-13-9

93-62-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  0.5 h, rt → 90 °C; pH 2, 50 °C

Reference

Process for preparation of ethanolamine-based amino acid chelating agents

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Nitrilotriacetic acid Raw materials

• ethanoldiglycine disodium salt

Nitrilotriacetic acid Preparation Products

• Nitrilotriacetic acid (139-13-9)
• N-(2-Hydroxyethyl)iminodiacetic acid (93-62-9)

• 1. Complexation of protactinium(v) with nitrilotriacetic acid: a study at the tracer scale
  C. Luchini,S. Leguay,J. Aupiais,C. Cannes,C. Le Naour New J. Chem. 2018 42 7789
• 2. Iron molybdenum nitrilotriacetate and iminodiacetate – spectroscopy, structural characterization and CO2 adsorption
  Si-Yuan Wang,Xin Dong,Jun-Fei Chen,Zhao-Hui Zhou New J. Chem. 2018 42 18526
• 3. Aminopolycarboxylic acids as a versatile tool to stabilize ceria nanoparticles – a fundamental model experimentally demonstrated
  Eric Johansson Salazar-Sandoval,Mats K. G. Johansson,Anwar Ahniyaz RSC Adv. 2014 4 9048
• 4. The crystal structure of trisodium nitriloacetate monohydrate
  J. J. Daly J. Chem. Soc. A 1967 1708
• 5. Five thermodynamic describers for addressing serendipity in the self-assembly of polynuclear complexes in solution
  Claude Piguet Chem. Commun. 2010 46 6209

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Nitrilotriacetic acid (NTA) and Its Significance in Modern Chemical Research

Nitrilotriacetic acid (CAS No. 139-13-9) is a versatile chelating agent that has garnered significant attention in the field of chemical biology and pharmaceutical research. Its unique structure, consisting of three carboxyl groups and one amine group, makes it highly effective in binding metal ions, which has broad implications in various applications, from industrial processes to biomedical interventions.

The compound's ability to form stable complexes with a wide range of metal ions has made it invaluable in the development of novel therapeutic agents. For instance, recent studies have highlighted its potential role in the treatment of metal ion deficiencies and toxicities. Researchers have explored its applications in correcting iron and zinc deficiencies, which are prevalent in many populations worldwide. The chelating properties of Nitrilotriacetic acid allow it to selectively bind with these metals, facilitating their absorption and utilization by the body.

In addition to its therapeutic applications, Nitrilotriacetic acid has been extensively studied for its environmental benefits. Its capacity to sequester heavy metals from contaminated soils and water systems has opened new avenues for environmental remediation. By binding with toxic metals such as lead and cadmium, it helps in their removal from ecosystems, thereby mitigating potential health risks associated with metal pollution.

Recent advancements in nanotechnology have further expanded the utility of Nitrilotriacetic acid. Researchers have developed nanostructured materials functionalized with this compound, which exhibit enhanced chelating efficiency. These nanoformulations are being tested for their effectiveness in targeted drug delivery systems, where precise control over metal ion release is crucial for therapeutic efficacy. The integration of Nitrilotriacetic acid into nanocarriers has shown promising results in improving the bioavailability of various drugs, thereby enhancing treatment outcomes.

The chemical properties of Nitrilotriacetic acid also make it a valuable tool in analytical chemistry. Its high affinity for metal ions allows for the development of sensitive detection methods for trace metal analysis. Techniques such as spectroscopy and chromatography have been enhanced by the inclusion of this compound, enabling more accurate and reliable measurements in fields ranging from food safety to environmental monitoring.

From a pharmaceutical perspective, the synthesis and modification of derivatives of Nitrilotriacetic acid have led to the discovery of new bioactive molecules. Researchers are investigating its role as a scaffold for designing drugs that target specific metal-dependent pathways in diseases such as cancer and neurodegenerative disorders. The ability of this compound to modulate metal ion homeostasis within cells offers a novel approach to therapeutic intervention.

The industrial applications of Nitrilotriacetic acid are equally diverse. In agriculture, it is used as a fertilizer supplement to enhance nutrient uptake by plants. Its chelating action ensures that essential metals like iron and manganese are readily available to crops, improving yield and quality. Moreover, its use in wastewater treatment plants has demonstrated effective removal of contaminants, contributing to cleaner water resources.

In conclusion, Nitrilotriacetic acid (CAS No. 139-13-9) stands as a cornerstone compound in modern chemical research due to its multifaceted applications. From addressing nutritional deficiencies and environmental pollution to advancing drug delivery systems and analytical techniques, its versatility continues to drive innovation across multiple disciplines. As research progresses, the full potential of this remarkable compound is likely to be further unlocked, offering solutions to some of the most pressing challenges in science and technology.

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