• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidinecarboxylic acids and derivatives

Recent Advances in the Application of 6-Methylpyrimidine-4-carboxylic acid (CAS: 138538-42-8) in Chemical Biology and Pharmaceutical Research

6-Methylpyrimidine-4-carboxylic acid (CAS: 138538-42-8) is a pyrimidine derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a crucial building block in the synthesis of various bioactive molecules, including kinase inhibitors, antiviral agents, and anti-inflammatory drugs. Recent studies have highlighted its potential in drug discovery, particularly in the development of targeted therapies for cancer and infectious diseases.

A study published in the Journal of Medicinal Chemistry (2023) demonstrated the efficacy of 6-Methylpyrimidine-4-carboxylic acid as a precursor in the synthesis of novel kinase inhibitors. The researchers utilized this compound to develop a series of small molecules targeting the PI3K/AKT/mTOR pathway, which is frequently dysregulated in cancer. The results showed promising inhibitory activity against multiple cancer cell lines, with IC50 values in the low micromolar range. This study underscores the potential of 6-Methylpyrimidine-4-carboxylic acid in the design of next-generation anticancer agents.

In another groundbreaking study, researchers explored the antiviral properties of derivatives synthesized from 6-Methylpyrimidine-4-carboxylic acid. The study, published in Antiviral Research (2024), reported that these derivatives exhibited potent activity against RNA viruses, including SARS-CoV-2 and influenza A. The mechanism of action was attributed to the inhibition of viral RNA polymerase, a critical enzyme in viral replication. These findings open new avenues for the development of broad-spectrum antiviral drugs.

The chemical versatility of 6-Methylpyrimidine-4-carboxylic acid also extends to its role in the synthesis of anti-inflammatory agents. A recent publication in Bioorganic & Medicinal Chemistry Letters (2023) described the use of this compound to create novel COX-2 inhibitors. The synthesized compounds demonstrated significant anti-inflammatory activity in vitro and in vivo, with reduced gastrointestinal side effects compared to traditional NSAIDs. This research highlights the potential of 6-Methylpyrimidine-4-carboxylic acid in addressing unmet medical needs in inflammatory diseases.

In conclusion, 6-Methylpyrimidine-4-carboxylic acid (CAS: 138538-42-8) continues to be a valuable scaffold in chemical biology and pharmaceutical research. Its applications in kinase inhibition, antiviral therapy, and anti-inflammatory drug development demonstrate its broad utility. Future research should focus on optimizing the pharmacokinetic properties of its derivatives and exploring their potential in clinical settings. The ongoing advancements in this field underscore the importance of this compound in modern drug discovery.

• 2164-65-0(2-Aminopyrimidine-4-carboxylic acid)
• 2450-08-0(Methyl pyrimidine-4-carboxylate)
• 13627-49-1(2-Methylpyrimidine-4-carboxylic acid)
• 16490-02-1(Pyrimidine-4,6-dicarboxylic acid)
• 6630-66-6(2-Amino-6-methylpyrimidine-4-carboxylic acid)
• 6345-43-3(4,6-dimethyl pyrimidine-4,6-dicarboxylate)
• 819850-18-5(Pyrimidine-4-carboxylic acid Sodium salt)
• 73955-53-0(Methyl 6-methylpyrimidine-4-carboxylate)
• 31462-59-6(Pyrimidine-4-carboxylic acid)
• 37645-41-3(2,4-Pyrimidinedicarboxylic acid)