• 1. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 4. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 5. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

Introduction to 5-chloro-4-ethylpyrimidine (CAS No. 137994-42-4)

5-chloro-4-ethylpyrimidine, with the chemical formula C?H?ClN?, is a significant compound in the field of pharmaceutical and agrochemical research. This heterocyclic organic compound belongs to the pyrimidine class, which is widely recognized for its diverse biological activities and applications. The presence of both chloro and ethyl substituents on the pyrimidine ring enhances its reactivity, making it a valuable intermediate in synthetic chemistry.

The compound is identified by its unique Chemical Abstracts Service (CAS) number, CAS No. 137994-42-4, which distinguishes it from other similar molecules in chemical databases. This specificity is crucial for researchers who need to ensure the purity and identity of their samples during synthesis and characterization processes.

In recent years, 5-chloro-4-ethylpyrimidine has garnered attention due to its potential applications in drug discovery. Pyrimidine derivatives are well-documented for their role in inhibiting various enzymes and receptors, thereby influencing a wide range of biological pathways. The chloro substituent, in particular, allows for further functionalization through nucleophilic substitution reactions, enabling the creation of more complex molecules.

One of the most promising areas of research involving 5-chloro-4-ethylpyrimidine is its use as a precursor in the synthesis of antiviral and anticancer agents. Studies have shown that pyrimidine-based compounds can interfere with viral replication by inhibiting key enzymes such as reverse transcriptase. Additionally, these compounds have been explored for their ability to disrupt DNA replication in cancer cells, making them candidates for novel therapeutic strategies.

The ethyl group in 5-chloro-4-ethylpyrimidine contributes to its solubility and bioavailability, factors that are critical for pharmaceutical applications. Researchers have leveraged this property to develop prodrugs that release active pharmaceutical ingredients (APIs) under specific physiological conditions. This approach has shown promise in improving drug delivery systems, ensuring targeted action and reduced side effects.

Advances in computational chemistry have also facilitated the design of new derivatives of 5-chloro-4-ethylpyrimidine with enhanced pharmacological properties. Molecular modeling techniques allow scientists to predict the binding affinity and metabolic stability of candidate compounds before they are synthesized in the lab. This high-throughput screening approach has significantly accelerated the drug discovery process.

Furthermore, the agrochemical industry has recognized the potential of 5-chloro-4-ethylpyrimidine as a building block for developing novel pesticides and herbicides. Pyrimidine derivatives exhibit potent activity against a variety of pests by disrupting essential biological processes. The versatility of this compound makes it an attractive candidate for sustainable agriculture practices that require effective pest management solutions.

In conclusion, 5-chloro-4-ethylpyrimidine (CAS No. 137994-42-4) is a multifaceted compound with significant implications in pharmaceuticals and agrochemicals. Its unique structural features enable diverse applications, from drug development to sustainable agriculture. As research continues to uncover new uses for this compound, it is likely to remain a cornerstone of innovation in synthetic chemistry and related fields.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)