• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 3. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 4. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

4-Chloro-3-fluorobenzylzinc bromide (CAS No. 1359839-23-8)

4-Chloro-3-fluorobenzylzinc bromide (CAS No. 1359839-23-8) is a versatile organometallic compound that has garnered significant attention in the fields of organic synthesis, materials science, and drug discovery. This compound, characterized by its unique structure and reactivity, serves as a valuable building block in the construction of complex molecules. The benzylzinc bromide framework, with its chlorine and fluorine substituents at the 4 and 3 positions respectively, offers a platform for diverse chemical transformations.

Recent advancements in organometallic chemistry have highlighted the potential of 4-chloro-3-fluorobenzylzinc bromide in cross-coupling reactions, particularly in the Suzuki-Miyaura coupling. This reaction enables the formation of biaryl compounds, which are crucial intermediates in pharmaceuticals and agrochemicals. The presence of electron-withdrawing groups (EWGs) such as chlorine and fluorine on the aromatic ring enhances the reactivity of the compound, making it an ideal substrate for these transformations.

In addition to its role in cross-coupling reactions, 4-chloro-3-fluorobenzylzinc bromide has been employed in nucleophilic aromatic substitution (NAS) reactions. The combination of EWGs on the aromatic ring facilitates the activation of specific positions for substitution, allowing for the synthesis of highly functionalized aromatic compounds. This property is particularly advantageous in the development of heterocyclic frameworks, which are prevalent in medicinal chemistry.

The synthesis of 4-chloro-3-fluorobenzylzinc bromide typically involves a two-step process: first, the preparation of the corresponding aryl halide, followed by transmetallation with zinc bromide. This method ensures high purity and stability of the final product. Recent studies have explored alternative synthetic routes, including microwave-assisted synthesis and continuous flow processes, to improve efficiency and scalability.

From a materials science perspective, benzylzinc bromide derivatives like CAS No. 1359839-23-8 are being investigated for their potential in organic electronics. The ability to tune electronic properties through substituent effects opens avenues for applications in flexible electronics and optoelectronic devices.

In conclusion, 4-chloro-3-fluorobenzylzinc bromide (CAS No. 1359839-23-8) stands as a testament to the ingenuity of modern organometallic chemistry. Its unique structure, reactivity, and versatility continue to drive innovation across multiple disciplines. As research progresses, this compound is poised to play an even more pivotal role in advancing both academic and industrial applications.

• 869893-91-4(Zinc, bromo[(3-chloro-2-fluorophenyl)methyl]-)
• 214976-40-6(5-Chloro-2-fluorobenzylzinc bromide)
• 1072789-40-2(2-Chloro-5-fluorobenzylzinc bromide)
• 1072787-65-5(2-chloro-4-fluorobenzylzinc bromide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)