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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Phthalazines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Phthalazines

4-Chlorophthalazin-1-amine (CAS 13580-86-4): Properties, Applications, and Market Insights

4-Chlorophthalazin-1-amine (CAS 13580-86-4) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and materials science research. This chlorinated phthalazine derivative features a unique molecular structure combining a phthalazine core with both chlorine and amine functional groups, making it valuable for various synthetic applications.

The compound's molecular formula C₈H₆ClN₃ gives it distinct chemical properties that researchers are exploring for multiple applications. Recent studies highlight its potential as a pharmaceutical intermediate, particularly in the development of novel therapeutic agents. The presence of both electron-withdrawing (chloro) and electron-donating (amino) groups creates interesting electronic properties that make 4-chlorophthalazin-1-amine valuable for drug discovery programs.

In the context of current research trends, this compound has shown promise in medicinal chemistry applications, with particular interest in its potential as a building block for kinase inhibitors. The global pharmaceutical industry's growing focus on targeted therapies has increased demand for specialized intermediates like 4-chlorophthalazin-1-amine CAS 13580-86-4. Researchers are particularly interested in its structure-activity relationships and how modifications to the phthalazine core might yield compounds with improved biological activity.

The synthesis of 4-chlorophthalazin-1-amine typically involves multi-step organic reactions starting from commercially available phthalic anhydride derivatives. Modern synthetic approaches emphasize green chemistry principles, with recent publications describing improved yields and reduced environmental impact. These advancements align with the chemical industry's broader sustainability goals and respond to increasing regulatory pressures for cleaner production methods.

From a commercial perspective, the market for phthalazine derivatives has shown steady growth, driven by pharmaceutical R&D expenditures. 4-Chlorophthalazin-1-amine occupies a niche but important position in this market, with suppliers offering various purity grades (typically 97-99%) to meet different research needs. Current pricing trends reflect the compound's specialized nature and the technical challenges associated with its production at scale.

Analytical characterization of CAS 13580-86-4 typically involves HPLC, NMR, and mass spectrometry techniques. Recent advancements in analytical technology have enabled more precise quality control, which is particularly important for pharmaceutical applications where impurity profiles can significantly impact downstream research. These analytical capabilities also support the compound's use in material science applications, where purity requirements may be equally stringent.

Storage and handling recommendations for 4-chlorophthalazin-1-amine follow standard laboratory practices for organic compounds. The material is typically supplied as a crystalline solid and should be protected from moisture and light to maintain stability. Proper storage conditions help preserve the compound's integrity for long-term research projects, an important consideration given the significant investment often involved in pharmaceutical development programs.

Looking to future applications, researchers are exploring the potential of 4-chlorophthalazin-1-amine derivatives in emerging areas such as organic electronics and advanced materials. The compound's conjugated system and ability to participate in various chemical transformations make it an interesting candidate for these cutting-edge applications. This aligns with broader scientific trends toward multifunctional materials with precisely tunable properties.

For researchers considering working with 4-chlorophthalazin-1-amine CAS 13580-86-4, several key suppliers offer the compound with detailed technical specifications. Comparative analysis of available products should consider factors such as purity, batch-to-batch consistency, and available documentation. These considerations become particularly important when the compound will be used in regulated research environments or for publication-quality work.

The scientific literature contains numerous references to chlorophthalazin-1-amine compounds, with recent publications focusing on their biological activity and synthetic utility. Researchers can find valuable information in journals covering medicinal chemistry, heterocyclic compounds, and organic synthesis. This growing body of literature supports the compound's continued relevance in chemical research and its potential for future discoveries.

In summary, 4-chlorophthalazin-1-amine represents an important building block in modern chemical research with applications spanning pharmaceutical development to advanced materials. Its unique structural features and chemical properties continue to attract research interest across multiple disciplines. As synthetic methods improve and new applications emerge, this compound is likely to maintain its position as a valuable tool for chemical innovation.

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