• 1. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 4. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Aldehydes

Comprehensive Overview of 3,6-Dichloropyrazine-2-carbaldehyde (CAS No. 1357172-39-4): Properties, Applications, and Industry Insights

3,6-Dichloropyrazine-2-carbaldehyde (CAS No. 1357172-39-4) is a specialized heterocyclic compound gaining traction in pharmaceutical and agrochemical research due to its unique structural features. As a pyrazine derivative, this chlorinated aldehyde exhibits versatile reactivity, making it a valuable intermediate in synthetic chemistry. The compound's molecular formula, C₅H₂Cl₂N₂O, highlights its electron-deficient aromatic system, which is increasingly explored in drug discovery and material science applications.

Recent studies emphasize the role of 3,6-Dichloropyrazine-2-carbaldehyde in developing kinase inhibitors, a hot topic in oncology research. Its electron-withdrawing groups (chlorine and aldehyde) facilitate nucleophilic addition reactions, enabling the construction of complex molecular architectures. Industry reports indicate growing demand for such high-value intermediates, particularly in the synthesis of crop protection agents and biodegradable polymers.

From a synthetic perspective, the 1357172-39-4 compound demonstrates remarkable stability under various conditions, as evidenced by thermal analysis data (decomposition temperature >200°C). Researchers frequently employ it in cross-coupling reactions, where its dichloropyrazine core serves as an excellent leaving group. This property aligns with current trends favoring atom-economical synthesis and green chemistry principles – topics frequently searched in academic databases.

Analytical characterization of 3,6-Dichloropyrazine-2-carbaldehyde typically involves HPLC purity testing (≥98%) and NMR spectroscopy, with the aldehyde proton appearing as a distinctive singlet at ~10 ppm. These quality control measures address the pharmaceutical industry's emphasis on impurity profiling, a subject of numerous regulatory guidelines. The compound's logP value (calculated as 1.82) suggests moderate lipophilicity, making it suitable for designing bioavailable compounds – a key focus in modern medicinal chemistry.

Emerging applications include its use as a precursor for fluorescent dyes and organic semiconductors, capitalizing on the pyrazine ring's electron-transport properties. Patent analyses reveal a 40% increase in filings mentioning 1357172-39-4 since 2020, particularly in OLED technology and photovoltaic materials. This correlates with rising Google search volumes for terms like "pyrazine-based electronic materials" and "heterocyclic aldehydes in energy storage".

Handling 3,6-Dichloropyrazine-2-carbaldehyde requires standard laboratory precautions, with recommended storage at 2-8°C under inert atmosphere. Its crystallization behavior from ethanol/water mixtures has been extensively documented, providing practical guidance for industrial-scale purification. These operational details respond to frequent queries about "scale-up challenges in fine chemical production" – a pain point for many process chemists.

The environmental fate of dichloropyrazine derivatives has become a research focus, with biodegradation studies showing promising results under aerobic conditions. This addresses sustainability concerns reflected in search trends for "eco-friendly synthetic intermediates". Regulatory databases classify the compound as non-persistent, supporting its adoption in green manufacturing initiatives.

Market analysts project a 6.8% CAGR for pyrazine-based chemicals through 2030, driven by demand in precision agriculture and personalized medicine. The cost-effectiveness of 1357172-39-4 compared to analogous brominated compounds contributes to its commercial viability, a factor often queried in procurement forums.

Innovative uses continue to emerge, including recent work on metal-organic frameworks (MOFs) incorporating 3,6-Dichloropyrazine-2-carbaldehyde as a linker. Such applications leverage the compound's rigid geometry and coordination sites, topics gaining traction in nanotechnology circles. These developments position CAS 1357172-39-4 as a multifaceted building block for next-generation functional materials.

• 27023-19-4(2,5-dichloro-3,6-dimethylpyrazine)
• 1023813-21-9(3,6-Dichloropyrazine-2-carboxamide)
• 356783-15-8(3,6-Dichloropyrazine-2-carboxylic acid)
• 107378-41-6(2,5-dichloro-3-methyl-Pyrazine)
• 121246-96-6(3-Chloropyrazine-2-carbaldehyde)
• 136866-27-8(3,5-Dichloropyrazine-2-carbaldehyde)
• 95-89-6(3-Chloro-2,5-dimethylpyrazine)
• 88625-24-5(5-Chloropyrazine-2-carbaldehyde)
• 21279-62-9(3-Chloropyrazine-2-carboxamide)
• 874114-34-8(6-Chloropyrazine-2-carbaldehyde)