Cas no 134523-03-8 (Atorvastatin hemicalcium salt)

Atorvastatin hemicalcium salt is a calcium salt form of atorvastatin, a selective and competitive inhibitor of HMG-CoA reductase. This compound is widely utilized as an active pharmaceutical ingredient (API) in cholesterol-lowering medications. The hemicalcium salt form enhances stability and solubility, facilitating formulation into solid dosage forms such as tablets. It exhibits high bioavailability and consistent pharmacokinetic properties, ensuring effective inhibition of cholesterol synthesis in the liver. The salt form also improves handling and storage characteristics compared to the free acid. Its well-documented efficacy in reducing LDL cholesterol and cardiovascular risk makes it a critical component in dyslipidemia management. Strict compliance with pharmacopeial standards ensures quality and reproducibility.
Atorvastatin hemicalcium salt structure
Atorvastatin hemicalcium salt structure
Product Name:Atorvastatin hemicalcium salt
CAS No:134523-03-8
MF:C66H68CaF2N4O10
MW:1155.34174442291
MDL:MFCD03613598
CID:64317
PubChem ID:9833468
Update Time:2025-09-02

Atorvastatin hemicalcium salt Chemical and Physical Properties

Names and Identifiers

    • Atorvastatin Calcium
    • ATORVASTATIN CA
    • [r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid calcium salt
    • 1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl)
    • delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-betcalci1h-pyrrole-1-heptanoicaci
    • pd134298-38a
    • ATORVASTATINCALCUIM
    • calcium (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoate
    • 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2:1), (R-(R*,R*))-
    • 1H-Pyrrole-1-heptanoic acid
    • beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2:1)
    • (R-(R*,R*))-, Atorvastatin calcium
    • Atorvastatin calcium (USAN)
    • Atorvastatin calcium salt
    • Atorvastatin calcium [USAN]
    • C08078
    • Calcium (betaR,deltaR)-2-(p-fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoate (1:2)
    • CI-981
    • D00887
    • DRG-0321
    • Lipibec
    • Lipitor
    • Lipitor (TN)
    • LS-136974
    • Prevencor
    • Sortis
    • Tahor
    • Torvast
    • YM-548
    • Atorvastatin Calsium
    • Atorvastatin calcium salt trihydrate
    • (3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5-Dihydroheptanoic Acid,calcium salt (2:1) Trihydrate
    • Atorvastatin (calcium salt)
    • Atorvastatin Calcium( Lipitor?, Stator?, Atoris?, Sortis?)
    • Atorvastatin hemicalcium
    • Atorvastatin hemicalcium salt
    • Atorvastatins Calcium
    • Atorvastatins Calcium amorphous
    • Calcium (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
    • atorvastatin
    • Cardyl
    • Tozalip
    • Xavator
    • Sotis
    • Atorvastatin [INN:BAN]
    • Liprimar
    • Tulip
    • C33H35FN2O5
    • (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid
    • A0JWA85V8F
    • (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid
    • Xarator
    • (betaR,
    • Atorvastatincalcium
    • FQCKMBLVYCEXJB-MNSAWQCASA-L
    • 134523-03-8
    • BA164226
    • Atorvastatin calcium anhydrous
    • GS-3563
    • CCG-270648
    • Atorvastatin calcium salt anhydrous
    • Tox21_111685_1
    • NCGC00159458-03
    • Tox21_111685
    • 1H-Pyrrole-1-heptanoicacid,2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calciumsalt(2:1),(betaR,deltaR)-
    • NSC-758617
    • Q27888052
    • Atorvastatin calcium (Lipitor)
    • SW219144-1
    • starbld0032749
    • Lipitor; Atorvastatin calcium
    • MFCD00899261
    • HMS3884H03
    • DTXCID4024303
    • UNII-C0GEJ5QCSO
    • 1316891-47-0
    • Rac-atorvastatin calcium
    • Atorvastatin calcium [USAN:USP]
    • Atorvastatin calcium anhydorous
    • Ranbaxy's Storvas
    • PD 134298-38A
    • NSC 758617
    • Storvas
    • CALCIUM (.BETA.R,.DELTA.R)-2-(P-FLUOROPHENYL)-.BETA.,.DELTA.-DIHYDROXY-5-ISOPROPYL-3-PHENYL-4-(PHENYLCARBAMOYL)PYRROLE-1-HEPTANOATE (1:2)
    • 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-,-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), (R,R)-
    • AM90286
    • 363599-71-7
    • SCHEMBL3832
    • C0GEJ5QCSO
    • YM 548
    • Tox21_302373
    • DTXSID6044303
    • CI 981
    • Atorvastatin calcium- Bio-X
    • calcium bis{(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate}
    • 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-.beta.,delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1),(.beta.R,.delta.R)-
    • Atorvastatin calcium (anhydrous)
    • 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-, calcium salt (2:1), (R-(R*,R*))-
    • NCGC00159458-05
    • 1H-Pyrrole-1-heptanoic acid, beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-, calcium salt (2:1), (R-(R*,R*))-
    • 1H-PYRROLE-1-HEPTANOIC ACID, 2-(4-FLUOROPHENYL)-.BETA.,.GAMMA.-DIHYDROXY-5- (1-METHYLETHYL)-3-PHENYL-4-((PHENYLAMINO)CARBONYL)-, CALCIUM SALT (2:1), (.BETA.R,.GAMMA.R)-
    • Rotacor
    • ATORVASTATIN CALCIUM [WHO-DD]
    • 1H-PYRROLE-1-HEPTANOIC ACID, 2-(4-FLUOROPHENYL)-.BETA.,.DELTA.-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-((PHENYLAMINO)CARBONYL)-, CALCIUM SALT (2:1), (R-(R*,R*))-
    • AKOS015896435
    • CHEMBL393220
    • (R,R)-2-(4-Fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
    • 1H-PYRROLE-1-HEPTANOIC ACID, 2-(4-FLUOROPHENYL)-B,D-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-((PHENYLAMINO)CARBONYL)-, CALCIUM SALT (2:1), (R-(R*,R*))-
    • J-006551
    • Atorvastan
    • NS00075355
    • calcium bis((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate)
    • CHEBI:50686
    • s2077
    • calcium;(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
    • BDBM50442868
    • Atorvastatin calcium hydrate
    • Kolevas
    • CAS-134523-03-8
    • NCGC00255845-01
    • Calcium bis{(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate}
    • ATORVASTATIN CALCIUM SALT ANHYDROUS [MI]
    • Atorvastatin calcium trihydrate
    • Lipitor , Atorvastatin hemicalcium , Atorvastatin Calcium , CI-981 , Sortis
    • MDL： MFCD03613598
    • Inchi： 1S/2C33H35FN2O5.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;;+2/p-2/t2*26-,27-;/m11./s1
    • InChI Key： FQCKMBLVYCEXJB-MNSAWQCASA-L
    • SMILES： [Ca+2].FC1C=CC(=CC=1)C1=C(C2C=CC=CC=2)C(C(NC2C=CC=CC=2)=O)=C(C(C)C)N1CC[C@H](C[C@H](CC(=O)[O-])O)O.FC1C=CC(=CC=1)C1=C(C2C=CC=CC=2)C(C(NC2C=CC=CC=2)=O)=C(C(C)C)N1CC[C@H](C[C@H](CC(=O)[O-])O)O

Computed Properties

  • Exact Mass: 1154.45000
  • Monoisotopic Mass: 558.253
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 41
  • Rotatable Bond Count: 12
  • Complexity: 822
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 112

Experimental Properties

  • Color/Form: Powder
  • Density: 6.95X10-25 mm Hg at 25 deg C (est)
  • Melting Point: 164-180°C
  • Boiling Point: 722.2oC at 760 mmHg
  • Flash Point: 390.6°C
  • Solubility: DMSO: ≥10mg/mL
  • PSA: 201.58000
  • LogP: 12.61900
  • Specific Rotation: -5.4° - -9.4° (c=1, DMSO)
  • Solubility: DMSO: ≥10mg/mL
  • Vapor Pressure: No data available

Atorvastatin hemicalcium salt Security Information

Atorvastatin hemicalcium salt Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Atorvastatin hemicalcium salt Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
YUN NAN XI LI SHENG WU JI SHU GU FEN Co., Ltd.
BBP80372-5mg
Atorvastatin calcium
 134523-03-8 98.0%
5mg
 ￥200 2021-05-07
MedChemExpress
HY-17379-10mM*1mLinDMSO
Atorvastatin hemicalcium salt
 134523-03-8 99.67％
10mM*1mLinDMSO
 ￥418 2023-07-26
MedChemExpress
HY-17379-10mg
Atorvastatin hemicalcium salt
 134523-03-8 99.67％
10mg
 ￥380 2024-05-24
MedChemExpress
HY-17379-50mg
Atorvastatin hemicalcium salt
 134523-03-8 99.67％
50mg
 ￥700 2024-05-24
MedChemExpress
HY-17379-100mg
Atorvastatin hemicalcium salt
 134523-03-8 99.67％
100mg
 ￥1045 2024-05-24
MedChemExpress
HY-17379-200mg
Atorvastatin hemicalcium salt
 134523-03-8 99.67％
200mg
 ￥1672 2024-05-24
MedChemExpress
HY-17379-500mg
Atorvastatin hemicalcium salt
 134523-03-8 99.67％
500mg
 ￥3500 2024-05-24
AstaTech
45400-5/G
ATORVASTATIN CALCIUM
 134523-03-8 97%
5g
 $61 2023-09-17
AstaTech
45400-25/G
ATORVASTATIN CALCIUM
 134523-03-8 97%
25g
 $174 2023-09-17
AstaTech
45400-100/G
ATORVASTATIN CALCIUM
 134523-03-8 97%
100/G
 $571 2022-06-02

Atorvastatin hemicalcium salt Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:134523-03-8)Atorvastatin calcium
Order Number:sfd9521
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:134523-03-8)阿托伐他汀鈣
Order Number:LE1694363;LE11840
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:34
Price ($):discuss personally
Zhengzhou Baoyu Pharmaceutical Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
(CAS:134523-03-8)Atorvastatin calcium
Order Number:LE043
Stock Status:in Stock
Quantity:5KG/1KG/25KG/100KG
Purity:99% HPLC
Pricing Information Last Updated:Thursday, 14 August 2025 14:44
Price ($):negotiated

Atorvastatin hemicalcium salt Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR

Atorvastatin hemicalcium salt Related Literature

Related Categories

Additional information on Atorvastatin hemicalcium salt

Atorvastatin Hemicalcium Salt: A Comprehensive Overview

Cas No. 134523-03-8, commonly referred to as Atorvastatin Hemicalcium Salt, is a widely recognized compound in the field of pharmaceuticals. This compound is a critical component in the synthesis of atorvastatin, a well-known statin drug used for managing high cholesterol levels. The compound's chemical structure, CAS registry number, and its role in drug development make it a subject of significant interest in both academic and industrial research.

The Atorvastatin Hemicalcium Salt is an intermediate in the production of atorvastatin calcium, which is a key medication for lowering LDL cholesterol. Recent studies have highlighted its importance in enhancing the bioavailability of atorvastatin, thereby improving its therapeutic efficacy. Researchers have explored various synthesis methods to optimize the production of this compound, ensuring higher purity and stability. These advancements have been documented in peer-reviewed journals, emphasizing the compound's role in modern pharmacology.

In terms of chemical properties, Cas No. 134523-03-8 exhibits unique characteristics that make it suitable for large-scale pharmaceutical manufacturing. Its solubility profile and stability under different conditions have been extensively studied, with findings published in recent scientific literature. These studies underscore the compound's compatibility with various excipients and its ability to withstand rigorous manufacturing processes without degradation.

The application of Atorvastatin Hemicalcium Salt extends beyond its role as an intermediate. It has been investigated for potential use in other therapeutic areas, such as cardiovascular diseases and metabolic disorders. Emerging research suggests that this compound may possess additional pharmacological activities that could be harnessed for developing new drugs. Such findings highlight the need for further exploration into its molecular mechanisms and therapeutic potentials.

From an environmental perspective, the synthesis and disposal of Cas No. 134523-03-8 have been scrutinized to ensure minimal ecological impact. Recent studies have focused on green chemistry approaches to minimize waste and improve sustainability during its production. These efforts align with global initiatives to promote eco-friendly practices in the pharmaceutical industry.

In conclusion, Atorvastatin Hemicalcium Salt, identified by its CAS registry number 134523-03-8, remains a pivotal compound in drug development. Its role as an intermediate in atorvastatin production, coupled with ongoing research into its chemical properties and therapeutic applications, underscores its significance in modern medicine. As scientific advancements continue to unfold, this compound is expected to play an even more prominent role in addressing cardiovascular health challenges worldwide.

134523-03-8 (Atorvastatin hemicalcium salt) Related Products

Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:134523-03-8)Atorvastatin calcium
sfd9521
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:134523-03-8)阿托伐他汀鈣
LE1694363;LE11840
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email