• 1. Controlled folding of polystyrene single chains: design of asymmetric covalent bridges
  Mirela Zamfir,Patrick Theato,Jean-Fran?ois Lutz Polym. Chem. 2012 3 1796
• 2. A versatile post-polymerization modification method for polyglutamic acid: synthesis of orthogonal reactive polyglutamates and their use in “click chemistry”
  Matthias Barz,Aroa Duro-Castano,María J. Vicent Polym. Chem. 2013 4 2989
• 3. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding
  M. Angeles Bonache,Alessandro Alaimo,Covadonga Malo,Oscar Millet,Alvaro Villarroel,Rosario González-Mu?iz Org. Biomol. Chem. 2014 12 8877
• 4. Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo
  Nishant Singh,Manuel Romero,Alessandra Travanut,Patricia F. Monteiro,Elena Jordana-Lluch,Kim R. Hardie,Paul Williams,Morgan R. Alexander,Cameron Alexander Biomater. Sci. 2019 7 4099
• 5. Molecularly imprinted magnetic materials prepared from modular and clickable nanoparticles
  Changgang Xu,Xiantao Shen,Lei Ye J. Mater. Chem. 2012 22 7427

• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds Azo imides
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons
• Other Chemical additives

Amino-PEG3-C2-Azido: A Versatile Building Block for Advanced Chemical and Biological Applications

Amino-PEG3-C2-Azido (CAS No. 134179-38-7) is a highly versatile and functionalized polyethylene glycol (PEG) derivative that has gained significant attention in the fields of chemical biology, drug delivery, and materials science. This compound is characterized by its unique combination of an amino group, a PEG3 spacer, and an azido functional group, making it an ideal building block for a wide range of applications.

The amino group in Amino-PEG3-C2-Azido provides a reactive site for conjugation with various biomolecules, such as proteins, peptides, and nucleic acids. This property is particularly valuable in the development of targeted drug delivery systems, where the amino group can be used to attach targeting ligands or therapeutic agents. Recent studies have demonstrated the effectiveness of using Amino-PEG3-C2-Azido to enhance the solubility and stability of hydrophobic drugs, thereby improving their pharmacokinetic properties.

The PEG3 spacer in Amino-PEG3-C2-Azido plays a crucial role in modulating the physicochemical properties of the conjugates. Polyethylene glycol (PEG) is known for its biocompatibility and ability to reduce immunogenicity and clearance rates. The PEG3 spacer ensures that the conjugated molecules maintain their biological activity while minimizing potential side effects. This feature is particularly important in the design of long-circulating nanoparticles and micelles for drug delivery applications.

The azido group in Amino-PEG3-C2-Azido offers a powerful tool for click chemistry reactions, specifically the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. This reaction is widely used in bioconjugation and materials science due to its high efficiency, selectivity, and mild reaction conditions. The azido group can be readily converted to a triazole ring through CuAAC, which provides a stable linkage between the PEG moiety and various functional groups or biomolecules. This versatility has led to numerous applications in protein labeling, cell surface engineering, and the synthesis of functional polymers.

In the context of drug discovery and development, Amino-PEG3-C2-Azido has been utilized to create prodrugs that are activated under specific biological conditions. For example, researchers have conjugated anticancer drugs to Amino-PEG3-C2-Azido using a cleavable linker that is sensitive to tumor microenvironment conditions such as low pH or high levels of specific enzymes. This approach has shown promise in reducing systemic toxicity while enhancing therapeutic efficacy.

Beyond its applications in drug delivery and bioconjugation, Amino-PEG3-C2-Azido has also found use in materials science. The combination of the PEG spacer and the reactive functional groups allows for the creation of advanced materials with tailored properties. For instance, it has been used to modify surfaces for improved biocompatibility or to create hydrogels with tunable mechanical properties for tissue engineering applications.

In summary, Amino-PEG3-C2-Azido (CAS No. 134179-38-7) is a highly versatile compound that offers unique opportunities for chemical and biological research. Its combination of an amino group, PEG3 spacer, and azido functional group makes it an invaluable tool for developing advanced drug delivery systems, bioconjugates, and functional materials. As research continues to advance in these areas, the potential applications of Amino-PEG3-C2-Azido are likely to expand even further.

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