Production Method 1

134-96-3

6915-15-7

80-69-3

121-34-6

Reaction Conditions

1.1R:NaOH, R:O2, C:CuO, S:H2O, 10-20 min, 120-200°C, 1 MPa

Reference

Oxidative Catalytic Fractionation of Lignocellulose to High-Yield Aromatic Aldehyde Monomers and Pure Cellulose

By Zhu, Yuting et al, ACS Catalysis, 2023, 13(12), 7929-7941

Production Method 2

9005-53-2

134-96-3

488-17-5

496-16-2

876-02-8

90-00-6

93-51-6

496-78-6

527-55-9

Reaction Conditions

1.1 Catalysts: Choline chloride ,  Imidazole ;  150 °C

Reference

Insights into alkaline choline chloride-based deep eutectic solvents pretreatment for Populus deltoides: Lignin structural features and modification mechanism

Li, Haichao; et al, International Journal of Biological Macromolecules, 2021, 193, 319-327

Production Method 3

134-96-3

97-54-1

831-00-5

3468-99-3

19037-58-2

90-05-1

61292-90-8

60563-13-5

72008-46-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Platinum Solvents: Ethanol ;  4 h, 250 °C

Reference

Lignin Depolymerization: A Comparison of Methods to Analyze Monomers and Oligomers

Bartolomei, Erika; et al, ChemSusChem, 2020, 13(17), 4633-4648

Syringaldehyde Raw materials

• Lignin

Syringaldehyde Preparation Products

• 3-Methylcatechol (488-17-5)
• Coumaran (496-16-2)
• 4'-Hydroxy-3'-methylacetophenone (876-02-8)
• 2-Ethylphenol (90-00-6)
• 2-Methoxy-4-methylphenol (93-51-6)
• Isoeugenol (97-54-1)
• Malic acid (6915-15-7)
• 2,4,5-trimethylphenol (496-78-6)
• Hydroxymalonic Acid (80-69-3)
• 2',4'-Dimethoxypropiophenone (831-00-5)
• 4,5-Dimethylbenzene-1,3-diol (527-55-9)
• Ethyl diphenylacetate (3468-99-3)
• Syringylacetone (19037-58-2)
• Vanillic acid (121-34-6)
• Guaiacol (90-05-1)
• Ethyl Hydroferulate (61292-90-8)
• Ethyl 2-(4-hydroxy-3-methoxyphenyl)acetate (60563-13-5)
• Syringaldehyde (134-96-3)
• 2-Cyclohexen-1-one, 2,4,4-trimethyl-3-(3-oxobutyl)- (72008-46-9)

• 1. Simultaneous determination of acid-soluble biomass-derived compounds using high performance anion exchange chromatography coupled with pulsed amperometric detection
  N. Anders,H. Humann,B. Langhans,A. C. Spie? Anal. Methods 2015 7 7866
• 2. Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans
  Mukesh Gangar,Avinash Ittuveetil,Sandeep Goyal,Anang Pal,Harikrishnan M.,Vipin A. Nair RSC Adv. 2016 6 102116
• 3. Simultaneous determination of vanillin and syringaldehyde in rum by derivative spectrophotometry
  F. García Sánchez,C. Carnero Ruiz,J. C. Márquez Gómez,M. Hernández López,A. Heredia Bayona Analyst 1990 115 1121
• 4. Singlet oxygen mediated degradation of lignin—isolation of oxidation products from steam-exploded lignin from pine
  Carlo Bonini,Maurizio D'Auria,Rachele Ferri Photochem. Photobiol. Sci. 2002 1 570
• 5. Analysis of aroma components from sugarcane to non-centrifugal cane sugar using GC-O-MS
  Erbao Chen,Huanlu Song,Yi Li,Haijun Chen,Bao Wang,Xianing Che,Yu Zhang,Shuna Zhao RSC Adv. 2020 10 32276

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Methoxyphenols
• Natural Products and Extracts Plant Extracts Plant based Senra incana
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Reference Substances
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Standard Substances
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients

Syringaldehyde (CAS No. 134-96-3): A Comprehensive Overview in Modern Chemical and Pharmaceutical Research

Syringaldehyde, with the chemical formula C?H?O? and CAS number 134-96-3, is a naturally occurring aromatic aldehyde that has garnered significant attention in the fields of chemical biology and pharmaceutical development. This compound, derived from the lignin fraction of plant cell walls, is a key intermediate in the synthesis of various bioactive molecules, making it a subject of extensive research across multiple disciplines.

The structural uniqueness of Syringaldehyde lies in its phenolic aldehyde moiety, which consists of a benzene ring substituted with both a hydroxyl (-OH) group and an aldehyde (-CHO) group. This bifunctional nature allows for diverse chemical modifications, enabling its incorporation into complex molecular architectures. The compound is particularly noted for its role in the biosynthesis of flavonoids and other polyphenolic compounds, which are widely recognized for their antioxidant and anti-inflammatory properties.

In recent years, Syringaldehyde has been extensively studied for its potential applications in drug discovery and development. Its ability to act as a precursor in the synthesis of various pharmacologically active agents has made it a valuable tool in medicinal chemistry. One of the most notable areas of research involves its use in the development of anti-cancer agents. Studies have demonstrated that derivatives of Syringaldehyde can inhibit the growth of certain cancer cell lines by interfering with critical cellular pathways involved in proliferation and survival.

Moreover, Syringaldehyde has shown promise in the field of neurodegenerative disease research. Emerging evidence suggests that this compound can protect against neurotoxicity induced by beta-amyloid peptides, which are implicated in Alzheimer's disease. The mechanism behind this protective effect is believed to involve the modulation of oxidative stress and inflammation, two key factors contributing to neuronal damage in neurodegenerative disorders.

The antimicrobial properties of Syringaldehyde have also been extensively explored. Research indicates that this compound exhibits broad-spectrum activity against various bacterial and fungal strains. This makes it a potential candidate for developing novel antimicrobial agents, particularly in light of the growing concern over antibiotic resistance. The antimicrobial efficacy of Syringaldehyde is attributed to its ability to disrupt bacterial cell membranes and interfere with essential metabolic processes.

In addition to its biological activities, Syringaldehyde has found applications in industrial processes as well. Its role as a flavoring agent in food products is well-documented, where it contributes to the characteristic aroma and taste profile of certain foods. Furthermore, its use as a chemical intermediate in the production of dyes and pigments highlights its versatility beyond pharmaceutical applications.

The synthesis of Syringaldehyde can be achieved through various chemical pathways, including oxidation of coniferyl alcohol or degradation of lignin-rich plant materials. Advances in biocatalysis have also enabled the production of Syringaldehyde using enzymatic methods, which offer a more sustainable and environmentally friendly approach compared to traditional chemical synthesis.

The pharmacokinetic profile of Syringaldehyde and its derivatives remains an area of active investigation. Understanding how these compounds are absorbed, distributed, metabolized, and excreted is crucial for optimizing their therapeutic potential. Preclinical studies have begun to unravel some aspects of their pharmacokinetics, providing valuable insights into their bioavailability and duration of action.

In conclusion, Syringaldehyde (CAS No. 134-96-3) represents a multifaceted compound with significant implications in both academic research and industrial applications. Its diverse biological activities, coupled with its role as a versatile chemical intermediate, make it a cornerstone molecule in modern chemical biology and pharmaceutical development. As research continues to uncover new applications and mechanisms associated with this compound, its importance is likely to grow even further.

• 29865-90-5(5-Hydroxy-3,4-dimethoxybenzaldehyde)
• 621-59-0(Isovanillin)
• 1189721-06-9(3,4,5-Trimethoxybenzaldehyde-d9)
• 86-81-7(3,4,5-Trimethoxybenzaldehyde)
• 120-14-9(Veratraldehyde)
• 121-33-5(Vanillin)
• 3934-87-0(3,4-Dihydroxy-5-methoxybenzaldehyde)
• 74495-73-1(3-Hydroxy-4-methoxybenzaldehyde-d3)
• 1173022-44-0(3,4-Dimethoxy7-13C-benzaldehyde)
• 74495-74-2(4-Hydroxy-3-methoxybenzaldehyde-d3)