• 1. An apparatus for testing water by measurement of its electrical conductivity
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• 2. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
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• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives Chlorinated biphenyls

Comprehensive Guide to 4-(4-Chloro-2-methoxyphenyl)phenylacetic acid (CAS No. 1334499-93-2): Properties, Applications, and Market Insights

4-(4-Chloro-2-methoxyphenyl)phenylacetic acid (CAS No. 1334499-93-2) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research. This phenylacetic acid derivative features a unique molecular structure combining a chloro-methoxy phenyl group with a phenylacetic acid backbone, making it valuable for various synthetic applications. Researchers frequently search for "CAS 1334499-93-2 uses" or "4-(4-Chloro-2-methoxyphenyl)phenylacetic acid synthesis," reflecting growing interest in its potential.

The compound's molecular formula (C15H13ClO3) and weight (276.71 g/mol) make it particularly useful as a pharmaceutical intermediate. Its chloro-methoxy substitution pattern contributes to enhanced bioavailability and target specificity in drug development. Recent studies highlight its relevance in addressing "anti-inflammatory drug discovery" and "metabolic disorder treatments" – two trending topics in medicinal chemistry. The carboxylic acid functional group allows for versatile derivatization, enabling researchers to explore novel "small molecule therapeutics."

From an industrial perspective, 4-(4-Chloro-2-methoxyphenyl)phenylacetic acid serves as a critical building block for specialty chemicals. Manufacturers often inquire about "CAS 1334499-93-2 suppliers" or "high-purity phenylacetic acid derivatives," indicating robust market demand. The compound's stability under standard conditions (typically stored at 2-8°C) and solubility profile (moderate in organic solvents) make it practical for laboratory and production-scale applications. Analytical techniques like HPLC and NMR are commonly employed for quality control.

The synthesis of 1334499-93-2 typically involves cross-coupling reactions or Grignard pathways, with researchers optimizing yields through "green chemistry approaches" – a hot topic in sustainable synthesis. Patent literature reveals its utility in developing "selective enzyme inhibitors" and "GPCR modulators," aligning with current drug discovery trends. Safety data sheets emphasize standard organic compound handling procedures, with no unusual hazards reported for this non-volatile crystalline solid.

Market analysis shows increasing procurement of 4-(4-Chloro-2-methoxyphenyl)phenylacetic acid by contract research organizations and generic drug manufacturers. Industry reports correlate this demand with the rise of "personalized medicine" and "targeted therapy development." The compound's structural versatility allows medicinal chemists to explore modifications addressing "drug resistance challenges" – a pressing concern in antimicrobial and anticancer research. Regulatory databases classify it as a standard research chemical with no special restrictions.

Quality specifications for CAS 1334499-93-2 typically require ≥98% purity by HPLC analysis, with strict limits on heavy metal contaminants. Analytical certificates often include UV-Vis spectra and melting point data (reported range 145-148°C) for verification. The growing emphasis on "quality by design" in pharmaceutical manufacturing has increased demand for well-characterized intermediates like this chloro-methoxy substituted compound.

Emerging applications include potential use in bioconjugation chemistry and prodrug development, particularly for "improved CNS penetration" – a frequent search term in neuropharmacology. The methoxy group's electron-donating properties and the chloro substituent's steric effects create unique opportunities for structure-activity relationship studies. Research papers increasingly reference this compound in investigations of "allosteric modulation" and "metabolite engineering."

For procurement considerations, technical documents recommend evaluating batch-to-batch consistency and residual solvent levels when sourcing 4-(4-Chloro-2-methoxyphenyl)phenylacetic acid. The compound's shelf life under proper storage conditions exceeds 24 months, making it practical for inventory management. Current Good Manufacturing Practice (cGMP) compliant versions are available for regulated applications, responding to industry needs for "pharma-grade intermediates."

• 77894-16-7([1,1'-Biphenyl]-4-aceticacid, 4'-chloro-2-methoxy-)
• 77894-08-7([1,1'-Biphenyl]-3-aceticacid, 4'-chloro-4-methoxy-)
• 75852-52-7([1,1'-Biphenyl]-3-aceticacid, 5-chloro-4'-methoxy-)
• 77894-15-6([1,1'-Biphenyl]-3-aceticacid, 4'-chloro-6-methoxy-)
• 77894-09-8([1,1'-Biphenyl]-3-aceticacid, 4'-chloro-2-methoxy-)
• 187269-42-7(2'-Methoxy-biphenyl-3-acetic Acid)
• 51028-89-8([1,1'-Biphenyl]-3-aceticacid, 4'-chloro-5-methoxy-)
• 77894-10-1([1,1'-Biphenyl]-4-aceticacid, 4'-chloro-3-methoxy-)
• 70958-20-2(2-(5-Chloro-2-phenoxyphenyl)acetic acid)
• 61888-61-7([1,1'-Biphenyl]-3-aceticacid, 4'-chloro-5-ethoxy-)