• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 3. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 4. Distinctive size effects of Pt nanoparticles immobilized on Fe3O4@PPy used as an efficient recyclable catalyst for benzylic alcohol aerobic oxidation and hydrogenation reduction of nitroaromatics
  Yu Long,Bing Yuan,Jianrui Niu,Xin Tong,Jiantai Ma New J. Chem., 2015,39, 1179-1185
• 5. Exclusive self-aligned β-phase PVDF films with abnormal piezoelectric coefficient prepared via phase inversion?
  N. Soin,D. Boyer,K. Prashanthi,S. Sharma,A. A. Narasimulu,J. Luo,T. H. Shah,E. Siores,T. Thundat Chem. Commun., 2015,51, 8257-8260

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

N,N,2-Trimethyl-5-nitro-benzamide (CAS 130370-02-4): A Comprehensive Overview

N,N,2-Trimethyl-5-nitro-benzamide (CAS 130370-02-4) is a specialized organic compound that has garnered attention in various research and industrial applications. This nitro-substituted benzamide derivative is characterized by its unique molecular structure, which includes a nitro group at the fifth position and three methyl groups attached to the benzene ring and amide nitrogen. The compound's chemical formula is C₁₀H₁₂N₂O₃, and it typically appears as a crystalline solid under standard conditions.

The synthesis of N,N,2-Trimethyl-5-nitro-benzamide involves multi-step organic reactions, often starting from commercially available precursors. Researchers frequently employ nitration reactions and amide coupling techniques to achieve the desired molecular architecture. The presence of both electron-withdrawing (nitro) and electron-donating (methyl) groups creates interesting electronic properties that make this compound valuable for pharmaceutical research and material science applications.

In recent years, N,N,2-Trimethyl-5-nitro-benzamide has become increasingly relevant in drug discovery programs, particularly as a potential building block for novel therapeutic agents. Its structural features make it a candidate for developing enzyme inhibitors and receptor modulators. The compound's nitrobenzamide moiety is particularly interesting to medicinal chemists exploring treatments for various conditions, aligning with current trends in precision medicine and targeted therapies.

The physicochemical properties of N,N,2-Trimethyl-5-nitro-benzamide contribute to its utility in multiple domains. With a molecular weight of 208.22 g/mol, the compound demonstrates moderate solubility in common organic solvents while being less soluble in water. These solubility characteristics make it suitable for various organic synthesis applications and formulation development. Researchers often investigate its spectroscopic properties, including UV-Vis absorption and NMR characteristics, which are valuable for analytical method development.

From a material science perspective, N,N,2-Trimethyl-5-nitro-benzamide has shown potential in the development of specialty chemicals. Its molecular structure allows for interesting interactions in polymer systems and could contribute to the creation of novel functional materials. This aligns with current industry demands for advanced materials with tailored properties, particularly in electronics and coatings applications.

The safety profile of N,N,2-Trimethyl-5-nitro-benzamide has been studied in various research contexts. While comprehensive toxicological data may be limited, standard laboratory precautions should be observed when handling this compound. Researchers emphasize the importance of proper personal protective equipment and ventilation systems when working with such specialized chemicals, reflecting the growing emphasis on laboratory safety standards in chemical research.

Market trends indicate growing interest in nitroaromatic compounds like N,N,2-Trimethyl-5-nitro-benzamide, particularly from pharmaceutical and agrochemical sectors. The compound's versatility as a synthetic intermediate makes it valuable for custom synthesis services and contract research organizations. Recent patent literature reveals innovative applications of similar structures, suggesting potential future directions for this chemical entity.

Analytical characterization of N,N,2-Trimethyl-5-nitro-benzamide typically involves techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. These methods ensure purity assessment and structural confirmation, which are critical for research applications. The development of robust analytical methods for such compounds remains an active area of investigation in analytical chemistry.

Storage and handling recommendations for N,N,2-Trimethyl-5-nitro-benzamide generally suggest keeping the material in a cool, dry environment, protected from light and moisture. These precautions help maintain the compound's stability over time, which is particularly important for long-term research projects. Proper chemical storage practices have become increasingly emphasized in research and industrial settings.

The future research directions for N,N,2-Trimethyl-5-nitro-benzamide appear promising, with potential applications emerging in various fields. Current scientific literature suggests interest in exploring its biological activity, material properties, and synthetic utility. As research continues to uncover new applications for nitroaromatic compounds, this particular benzamide derivative may find expanded uses in both academic and industrial contexts.

For researchers seeking high-purity N,N,2-Trimethyl-5-nitro-benzamide, several specialty chemical suppliers offer the compound in various quantities. The availability of this material through custom synthesis routes has increased in recent years, reflecting growing demand from the scientific community. Quality control measures and certificates of analysis have become standard requirements for such specialized chemicals.

In conclusion, N,N,2-Trimethyl-5-nitro-benzamide (CAS 130370-02-4) represents an interesting case study in the application of nitroaromatic chemistry to modern research challenges. Its unique structural features and potential applications across multiple disciplines make it a compound worth watching in coming years. As scientific understanding of such molecules deepens, we can anticipate new discoveries and applications for this versatile chemical entity.

• 110568-64-4(6-Nitroisoindolin-1-one)
• 876343-38-3(5-Nitroisoindolin-1-one)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)