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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonic acids and derivatives

Sodium 2-Hydroxybenzenesulfonate (CAS No. 1300-51-2): An Overview of Its Properties, Applications, and Recent Research

Sodium 2-hydroxybenzenesulfonate (CAS No. 1300-51-2) is a versatile compound with a wide range of applications in various industries, including pharmaceuticals, cosmetics, and chemical synthesis. This compound is known for its excellent solubility in water and its ability to form stable complexes with various metal ions. In this article, we will delve into the chemical properties, applications, and recent research developments surrounding Sodium 2-hydroxybenzenesulfonate.

Chemical Properties: Sodium 2-hydroxybenzenesulfonate is a white crystalline powder with the molecular formula C₇H₆NaO₄S. It has a molecular weight of 206.18 g/mol and is highly soluble in water. The compound exhibits strong acidic properties due to the presence of the sulfonic acid group (-SO₃H), which can be easily neutralized by sodium ions to form the sodium salt. This property makes it useful in various chemical reactions and formulations.

Synthesis: The synthesis of Sodium 2-hydroxybenzenesulfonate typically involves the sulfonation of phenol followed by neutralization with sodium hydroxide. The reaction can be represented as follows:

C₆H₅OH + H₂SO₄ → C₆H₄(OH)SO₃H + H₂O

C₆H₄(OH)SO₃H + NaOH → C₆H₄(OH)SO₃^-Na⁺ + H₂O

This process yields a high-purity product that can be further purified by recrystallization or other methods to meet specific industrial requirements.

Applications:

Sodium 2-hydroxybenzenesulfonate finds extensive use in the pharmaceutical industry due to its ability to enhance the solubility and stability of various drugs. It is often used as a solubilizing agent in drug formulations, particularly for poorly water-soluble compounds. This property is crucial for improving the bioavailability and therapeutic efficacy of drugs.

In cosmetics, Sodium 2-hydroxybenzenesulfonate is used as a surfactant and emulsifier in skin care products, shampoos, and other personal care items. Its mild nature and excellent foaming properties make it a preferred choice for formulators seeking gentle yet effective ingredients.

The compound also has applications in chemical synthesis, where it serves as a reagent or catalyst in various reactions. Its ability to form stable complexes with metal ions makes it useful in coordination chemistry and catalysis.

The ongoing research on Sodium 2-hydroxybenzenesulfonate has led to several exciting findings that highlight its potential in new areas of application. One recent study published in the Journal of Medicinal Chemistry explored the use of Sodium 2-hydroxybenzenesulfonate-based derivatives as potential anticancer agents. The researchers found that these derivatives exhibited significant cytotoxic activity against various cancer cell lines, suggesting their potential for further development as therapeutic agents.

In another study, scientists investigated the use of Sodium 2-hydroxybenzenesulfonate-based nanoparticles for drug delivery systems. The results showed that these nanoparticles could effectively encapsulate and deliver drugs to target sites with improved efficiency and reduced side effects. This research opens up new possibilities for the development of advanced drug delivery systems using this versatile compound.

A third area of research focuses on the environmental impact of Sodium 2-hydroxybenzenesulfonate. Studies have shown that this compound is biodegradable and does not pose significant environmental risks when used within recommended concentrations. However, ongoing research continues to monitor its long-term effects on ecosystems to ensure its safe use in industrial applications.

Safety Considerations:

Sodium 2-hydroxybenzenesulfonate is generally considered safe when used as directed. However, like any chemical compound, it should be handled with appropriate precautions to avoid skin contact or inhalation of dust particles. Proper personal protective equipment (PPE) such as gloves and safety goggles should be worn during handling to ensure safety.

In conclusion, Sodium 2-hydroxybenzenesulfonate (CAS No. 1300-51-2) is a multifaceted compound with a wide range of applications across various industries. Its unique chemical properties make it an essential component in pharmaceuticals, cosmetics, and chemical synthesis. Ongoing research continues to uncover new potential uses for this compound, further solidifying its importance in modern science and technology.

• 135-51-3(3-Hydroxynaphthalene-2,7-disulfonic Acid Disodium Salt (Technical Grade))
• 83949-45-5(Sodium 2-naphthol-3,7-disulfonate)
• 36747-37-2(Benzoic acid, 4-sulfo-,sodium salt (1:?))
• 7153-21-1(2,7-Naphthalenedisulfonic acid, 3,6-dihydroxy-, disodium salt)
• 1300-37-4(Barium bis(hydroxybenzenesulphonate))
• 29632-98-2(Benzenesulfonic acid,2,5-dihydroxy-, sodium salt (1:?))
• 1300-47-6(Benzenesulfonic acid,hydroxy-, lithium salt (1:1))
• 1300-41-0(Benzenesulfonic acid,hydroxy-, calcium salt (2:1))
• 10021-55-3(Sodium 2,5-dihydroxybenzenesulfonate)
• 15883-57-5(3-Hydroxy-2,7-naphthalenedisulfonic Acid Sodium Salt > 90%)