Cas no 128270-60-0 (Bivalirudin)
Bivalirudin is a synthetic 20-amino acid peptide that functions as a direct thrombin inhibitor. It binds reversibly to both free and clot-bound thrombin, exhibiting high specificity for the active site of the enzyme. Its primary advantage lies in its predictable anticoagulant effect, with a short half-life (~25 minutes in healthy subjects) and linear pharmacokinetics, allowing for precise dose titration. Unlike heparin, Bivalirudin does not require antithrombin III for activity and demonstrates minimal interaction with platelets, reducing the risk of heparin-induced thrombocytopenia (HIT). It is primarily used in percutaneous coronary interventions (PCI) and acute coronary syndromes, offering a favorable safety profile with reduced bleeding complications compared to traditional anticoagulants.
Bivalirudin structure
Product Name:Bivalirudin
CAS No:128270-60-0
MF:C98H138N24O33
MW:2180.285343647
MDL:MFCD08282793
CID:63930
PubChem ID:16129704
Update Time:2025-06-07
Bivalirudin Chemical and Physical Properties
Names and Identifiers
-
- Bivalirudin
- Bivalirudin Trifluoroacetate
- Angiomax
- BG-8967
- bivalirudina
- DPHE-PRO-ARG-PRO-GLY-GLY-GLY-GLY-ASN-GLY-ASP-PHE-GLU-GLU-LLE-PRO-GLU-GLU-TYR-LEU
- Hirulog
- Hirulog-1
- BG 8967
- Hirulog 1
- BITTERMELONP.E
- Bivalirudin, TFA
- Human Bivalirudin
- Bivalirudin Acetate
- Bivalirudin Trifluoacetate
- BG 8967, Hirulog, Hirulog I
- Hirulog trifluoroacetate salt
- Bivalirudin trifluoroacetate salt
- Bivalirudin trifluoroacetate (H-DL-Phe-DL-Pro-DL-Arg-DL-Pro-Gly-Gly-Gly-Gly-DL-Asn-Gly-DL-Asp-DL-Phe-DL-Glu-DL-Glu-xiIle-DL-Pro-DL-Glu-DL-Glu-DL-Tyr-DL-Leu-OH.TFA)
- HS-2004
- GTPL6470
- Phe-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu
- Phe-Pro-Arg-Pro-(Gly)4 desulfato-Tyr63'-hirugen
- 128270-60-0
- BIVALIRUDIN IN 0.9% SODIUM CHLORIDE
- CHEBI:59173
- Angiox
- MFCD08692016
- AKOS015994644
- D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine
- DTXCID4078338
- BivalirudinRTU
- AC-8916
- BDBM50248103
- bivalirudine
- Q4919218
- Bivalirudin [USAN:INN:BAN]
- Bivalirudin;0.9% Sodium Chloride
- BG8967
- UNII-TN9BEX005G
- 1191386-55-6
- Bivalirudin TFA
- BIVALIRUDIN (MART.)
- Angiomax RTU
- CHEMBL2103749
- Phe-Pro-Arg-Pro-(Gly)4-desulfohirudin-(53-64)
- bivalirudinum
- NS00078779
- B01AE06
- DB00006
- SCHEMBL25739
- EX-A5843
- TN9BEX005G
- L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-
- BIVALIRUDIN (USP-RS)
- J-005587
- DTXSID00155847
- BRD-K73504359-001-01-3
- DA-71564
-
- MDL： MFCD08282793
- Inchi： 1S/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1
- InChI Key： OIRCOABEOLEUMC-GEJPAHFPSA-N
- SMILES： O=C([C@H]([C@@H](C)CC)NC([C@H](CCC(=O)O)NC([C@H](CCC(=O)O)NC([C@H](CC1C=CC=CC=1)NC([C@H](CC(=O)O)NC(CNC([C@H](CC(N)=O)NC(CNC(CNC(CNC(CNC([C@@H]1CCCN1C([C@H](CCCNC(=N)N)NC([C@@H]1CCCN1C([C@@H](CC1C=CC=CC=1)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)O)CC(C)C)=O)CC1C=CC(=CC=1)O)=O)CCC(=O)O)=O)CCC(=O)O)=O
Computed Properties
- Exact Mass: 2178.99000
- Monoisotopic Mass: 2178.986
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 28
- Hydrogen Bond Acceptor Count: 57
- Heavy Atom Count: 155
- Rotatable Bond Count: 86
- Complexity: 4950
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 16
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 902A^2
- XLogP3: -7.1
Experimental Properties
- Color/Form: No data avaiable
- Density: 1.3±0.1 g/cm3
- Melting Point: No data available
- Boiling Point: 548.6±50.0 °C at 760 mmHg
- Flash Point: 285.6±30.1 °C
- Refractive Index: 1.675
- PSA: 901.57000
- LogP: 0.54320
- Vapor Pressure: 0.0±3.3 mmHg at 25°C
Bivalirudin Security Information
- Signal Word：Warning
- Hazard Statement： H302-H315-H319-H335
- Warning Statement： P261-P305+P351+P338
- Safety Instruction： H303+H313+H333
- Storage Condition：Powder -80°C 2 years ? -20°C 1 year In solvent -80°C 6 months ? -20°C 1 month
Bivalirudin Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci5138-100mg |
Bivalirudin Trifluoroacetate |
128270-60-0 | 98% | 100mg |
￥1000.00 | 2023-09-10 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci5138-500mg |
Bivalirudin Trifluoroacetate |
128270-60-0 | 98% | 500mg |
￥3175.00 | 2023-09-10 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T5519-10 mg |
Bivalirudin |
128270-60-0 | 98.80% | 10mg |
￥380.00 | 2022-04-26 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T5519-50 mg |
Bivalirudin |
128270-60-0 | 98.80% | 50mg |
￥1028.00 | 2022-04-26 | |
| Apollo Scientific | BITP1474-1mg |
Human Bivalirudin |
128270-60-0 | 1mg |
￡85.00 | 2025-02-22 | ||
| Apollo Scientific | BITP1474-5mg |
Human Bivalirudin |
128270-60-0 | 5mg |
￡215.00 | 2025-02-22 | ||
| Apollo Scientific | BITP1474-100mg |
Human Bivalirudin |
128270-60-0 | 100mg |
￡745.00 | 2025-02-22 | ||
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0996569347-10mg |
Bivalirudin |
128270-60-0 | 99% | 10mg |
￥ 399.1 | 2024-07-19 | |
| eNovation Chemicals LLC | Y1014368-50mg |
L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-aspartyl-L-phenylalanyl-L-glutamyl-L-glutamyl-L-isoleucyl-L-prolyl-L-glutamyl-L-glutamyl-L-tyrosyl- |
128270-60-0 | 99% | 50mg |
$335 | 2023-09-04 | |
| eNovation Chemicals LLC | Y1106039-1g |
Bivalirudin |
128270-60-0 | 95% | 1g |
$650 | 2024-07-23 |
Bivalirudin Suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:128270-60-0)比伐盧定
Order Number:LE26536667
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:56
Price ($):discuss personally
Email:[email protected]
Bivalirudin Related Literature
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K. Y. Kiran Kumar,Venugopala Rao Dama,Ch. Suchitra,Thirumala Chary Maringanti Anal. Methods 2020 12 304
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D. S. Chu,D. L. Sellers,M. J. Bocek,A. E. Fischedick,P. J. Horner,S. H. Pun Biomater. Sci. 2015 3 41
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Jason Lee,Tianyu Zhao,David J. Peeler,Daniel C. Lee,Trey J. Pichon,David Li,Kathleen M. Weigandt,Philip J. Horner,Lilo D. Pozzo,Drew L. Sellers,Suzie H. Pun Soft Matter 2020 16 3762
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Sandip Jadhav,Vincent Martin,Peter H. G. Egelund,Henrik Johansson Castro,Tobias Krüger,Franziska Richner,Sebastian Thordal Le Quement,Fernando Albericio,Frank Dettner,Carolin Lechner,Ralph Sch?nleber,Daniel Sejer Pedersen Green Chem. 2021 23 3312
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Yingqi Chen,Xuan Zhang,Sheng Zhao,Manfred F. Maitz,Wentai Zhang,Su Yang,Jinlong Mao,Nan Huang,Guojiang Wan J. Mater. Chem. B 2017 5 4162
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Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:128270-60-0)比伐盧定
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry