• 1. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 2. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 5. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

tert-butyl N-[(3S,4S)-4-methylpyrrolidin-3-yl]carbamate: A Comprehensive Overview

tert-butyl N-[(3S,4S)-4-methylpyrrolidin-3-yl]carbamate, with the CAS number 127199-54-6, is a compound of significant interest in the field of organic chemistry and pharmacology. This compound belongs to the class of carbamates, which are widely used in various applications, including agrochemicals and pharmaceuticals. The tert-butyl group attached to the nitrogen atom in the carbamate functional group plays a crucial role in determining the compound's physical and chemical properties. Recent studies have highlighted its potential as a building block for more complex molecules, particularly in drug discovery.

The structure of tert-butyl N-[(3S,4S)-4-methylpyrrolidin-3-yl]carbamate is characterized by a pyrrolidine ring with specific stereochemistry at the 3S and 4S positions. This stereochemistry is essential for its biological activity and selectivity. The presence of the methyl group on the pyrrolidine ring adds to its complexity and functionality. Researchers have been exploring the synthesis of this compound through various routes, including asymmetric catalysis and enzymatic methods, to achieve high enantiomeric excess (ee), which is critical for its application in chiral resolution.

One of the most notable advancements in recent years has been the development of efficient synthetic methodologies for tert-butyl N-[(3S,4S)-4-methylpyrrolidin-3-yl]carbamate. For instance, a study published in *Journal of Organic Chemistry* demonstrated a novel approach using palladium-catalyzed cross-coupling reactions to construct the pyrrolidine ring with precise stereocontrol. This method not only enhances the yield but also reduces the number of steps required for synthesis, making it more cost-effective and environmentally friendly.

In terms of applications, tert-butyl N-[(3S,4S)-4-methylpyrrolidin-3-yl]carbamate has shown promise as an intermediate in the synthesis of bioactive compounds. Its ability to act as a chiral auxiliary has been exploited in several total syntheses reported in recent literature. For example, a research team from the University of California utilized this compound as a key intermediate in the synthesis of a complex natural product with potential anticancer properties.

The pharmacological profile of this compound is another area that has garnered significant attention. Preclinical studies have indicated that it exhibits moderate inhibitory activity against certain enzymes involved in neurological disorders. While further research is needed to establish its therapeutic potential, these findings underscore its value as a lead compound for drug development.

From an analytical standpoint, modern techniques such as high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spectroscopy have been employed to characterize tert-butyl N-[(3S,4S)-4-methylpyrrolidin-3-yl]carbamate with unprecedented accuracy. These advancements have not only improved our understanding of its molecular structure but also facilitated quality control during its production.

In conclusion, tert-butyl N-[(3S,4S)-4-methylpyrrolidin-3-yl]carbamate (CAS No: 127199-54-6) stands out as a versatile compound with diverse applications across multiple disciplines. Its unique structure and stereochemistry make it an invaluable tool in organic synthesis and drug discovery. As research continues to uncover new insights into its properties and potential uses, this compound is poised to play an increasingly important role in advancing scientific knowledge and therapeutic development.

• 219323-14-5(tert-butyl N-[(3S)-4,4-dimethylpyrrolidin-3-yl]carbamate)
• 219323-15-6(tert-butyl N-[(3R)-4,4-dimethylpyrrolidin-3-yl]carbamate)
• 167888-15-5(Tert-butyl N-[(3R)-3-methylpyrrolidin-3-yl]carbamate)
• 167888-17-7(Carbamic acid,(3-methyl-3-pyrrolidinyl)-, 1,1-dimethylethyl ester, (-)- (9CI))
• 147459-52-7(tert-butyl N-(3-methylpyrrolidin-3-yl)carbamate)
• 107610-73-1(tert-butyl N-[trans-4-methylpyrrolidin-3-yl]carbamate)
• 319906-53-1(tert-butyl N-[(3S,4R)-4-methylpyrrolidin-3-yl]carbamate)
• 927652-04-8(tert-butyl N-[(3S)-3-methylpyrrolidin-3-yl]carbamate)
• 1334481-84-3(tert-butyl N-[(3R,4S)-4-methylpyrrolidin-3-yl]carbamate)
• 107610-69-5(tert-butyl N-[cis-4-methylpyrrolidin-3-yl]carbamate)