• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002

Introduction to 3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid (CAS No. 1261930-84-0)

3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid, identified by the Chemical Abstracts Service Number (CAS No.) 1261930-84-0, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the class of benzoic acid derivatives, characterized by its unique structural features that include both chloro and trifluoromethyl substituents on the aromatic ring. These structural elements contribute to its distinct chemical properties, making it a valuable intermediate in the synthesis of various pharmacologically active molecules.

The presence of chloro groups at the 3 and 4 positions on the phenyl ring enhances the electrophilicity of the molecule, facilitating its participation in nucleophilic substitution reactions. This property is particularly useful in multi-step synthetic pathways where selective functionalization is required. On the other hand, the trifluoromethyl group at the 5 position introduces electron-withdrawing effects, which can influence both the electronic and steric properties of the molecule. This modification is often employed to improve metabolic stability and binding affinity in drug candidates.

Recent advancements in medicinal chemistry have highlighted the importance of benzoic acid derivatives in developing novel therapeutic agents. The structural motif of 3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid has been explored in various contexts, particularly in the design of small-molecule inhibitors targeting key biological pathways. For instance, studies have demonstrated its potential utility in inhibiting enzymes involved in inflammatory responses and cancer progression. The compound’s ability to interact with biological targets due to its optimized pharmacophore has made it a subject of interest for further pharmacological investigation.

In terms of synthetic chemistry, 3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid serves as a versatile building block for constructing more complex molecules. Its benzoic acid core can be further modified through various chemical transformations, such as esterification, amidation, or alkylation, to generate derivatives with tailored biological activities. The chloro and trifluoromethyl groups provide handles for selective functionalization, allowing chemists to fine-tune the properties of the resulting compounds. This flexibility has been leveraged in the development of novel agrochemicals and specialty chemicals, where precise structural control is essential.

The pharmaceutical industry has shown particular interest in this compound due to its potential as a lead molecule for drug discovery. Preclinical studies have indicated that derivatives of 3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid exhibit promising activities against several diseases. For example, researchers have investigated its efficacy in modulating enzyme cascades associated with neurodegenerative disorders and autoimmune conditions. The compound’s ability to penetrate biological membranes and reach target sites efficiently makes it an attractive candidate for further development.

From a chemical biology perspective, understanding the interactions between 3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid and biological targets is crucial for optimizing its therapeutic potential. High-throughput screening (HTS) techniques have been employed to identify hit compounds based on their binding affinity to specific proteins or enzymes. Computational methods such as molecular docking and molecular dynamics simulations have also been utilized to predict how this compound might interact with biological systems at an atomic level. These approaches provide valuable insights into structure-activity relationships (SARs), guiding medicinal chemists in designing more effective derivatives.

The environmental impact of benzoic acid derivatives is another area of growing concern. While these compounds offer numerous benefits in pharmaceutical applications, their persistence in ecosystems can pose risks if not managed properly. Researchers are actively exploring sustainable synthetic routes that minimize waste and reduce environmental footprints. Green chemistry principles are being integrated into the synthesis of 3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid, focusing on using renewable resources and catalytic methods that enhance efficiency while lowering toxic byproducts.

In conclusion,3-(3,4-Dichlorophenyl)-5-trifluoromethylbenzoic acid (CAS No. 1261930-84-0) represents a significant advancement in organic synthesis and drug discovery. Its unique structural features make it a valuable tool for developing novel therapeutic agents with potential applications across multiple disease areas. As research continues to uncover new possibilities for this compound and its derivatives,its role in pharmaceutical innovation is likely to expand further, driving progress towards more effective treatments for human health challenges.

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