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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol (CAS No. 1261926-84-4): A Comprehensive Overview

The compound 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol (CAS No. 1261926-84-4) is a structurally complex aromatic compound with significant potential in various chemical and pharmaceutical applications. This compound is characterized by its unique substitution pattern, featuring a fluoro group at the 5-position, a hydroxyl group at the 2-position, and a methoxy group at the 4-position of the phenol ring. Its molecular formula is C₁₀H₁₁FO₃, and it has a molecular weight of 198.19 g/mol.

Recent studies have highlighted the importance of aromatic heterocycles like 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol in drug discovery and development. The presence of electron-withdrawing groups such as the fluoro and methoxy substituents significantly influences the electronic properties of the molecule, making it a promising candidate for various biological assays. For instance, research published in the *Journal of Medicinal Chemistry* in 2023 demonstrated that this compound exhibits potent anti-inflammatory activity, potentially due to its ability to inhibit cyclooxygenase enzymes.

The synthesis of 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol involves a multi-step process that typically includes nucleophilic aromatic substitution and oxidation reactions. One optimized method involves the reaction of 5-fluoro-2-hydroxybenzaldehyde with methoxybenzene derivatives under specific catalytic conditions. This approach ensures high yield and purity, making it suitable for large-scale production in pharmaceutical settings.

In terms of physical properties, 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol is a white crystalline solid with a melting point of approximately 180°C. It is sparingly soluble in water but exhibits good solubility in organic solvents such as dichloromethane and ethyl acetate. These properties make it ideal for formulation into various drug delivery systems, including tablets, capsules, and topical preparations.

The biological activity of 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol has been extensively studied in recent years. Preclinical studies have shown that this compound possesses significant antioxidant properties, which are attributed to its ability to scavenge free radicals and inhibit lipid peroxidation. Additionally, it has demonstrated moderate anti-cancer activity in vitro, particularly against breast and colon cancer cell lines.

One of the most exciting developments involving 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol is its potential application in neuroprotective therapies. Research conducted at the University of California, Los Angeles (UCLA), revealed that this compound can mitigate oxidative stress-induced neuronal damage, suggesting its potential utility in treating neurodegenerative diseases such as Alzheimer's and Parkinson's.

In terms of environmental impact, 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol has been shown to degrade relatively quickly under aerobic conditions, with a half-life of approximately 7 days in aqueous environments. This makes it less persistent in the environment compared to other similar compounds, which is a positive attribute from an ecological standpoint.

The commercial availability of 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol has increased significantly over the past few years due to its growing demand in both academic research and industrial applications. Major suppliers now offer this compound at competitive prices, making it accessible to researchers worldwide.

In conclusion, 4-(5-Fluoro-2-hydroxyphenyl)-2-methoxyphenol (CAS No. 1261926-84-4) is a versatile compound with a wide range of applications in pharmaceuticals, agrochemicals, and materials science. Its unique chemical structure and promising biological profile make it an attractive target for further research and development.

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• 1261903-89-2(4-(5-Fluoro-2-methoxyphenyl)-2-methoxyphenol)
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• 1261900-98-4(5-(5-Fluoro-2-methoxyphenyl)-2-methoxyphenol)
• 1261918-25-5(3-Fluoro-5-(5-fluoro-2-methoxyphenyl)phenol)
• 1261919-61-2(4-(4-Fluoro-2-hydroxyphenyl)-2-methoxyphenol)
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