Cas no 1225773-98-7 (3-(5-fluoro-2-methoxyphenyl)phenol)

3-(5-Fluoro-2-methoxyphenyl)phenol is a fluorinated aromatic compound featuring a phenol group and a methoxy-substituted phenyl ring. Its molecular structure, incorporating both electron-donating (methoxy) and electron-withdrawing (fluoro) substituents, makes it a versatile intermediate in organic synthesis and pharmaceutical research. The fluorine moiety enhances metabolic stability and binding affinity in bioactive molecules, while the phenolic group allows for further functionalization. This compound is particularly valuable in the development of fluorinated drug candidates, agrochemicals, and advanced materials. Its high purity and well-defined reactivity profile ensure consistent performance in coupling reactions, electrophilic substitutions, and other synthetic transformations. Suitable for controlled environments, it requires handling under inert conditions due to its phenolic functionality.
3-(5-fluoro-2-methoxyphenyl)phenol structure
1225773-98-7 structure
Product Name:3-(5-fluoro-2-methoxyphenyl)phenol
CAS No:1225773-98-7
MF:C13H11FO2
MW:218.223647356033
MDL:MFCD16484437
CID:1217024
PubChem ID:52984013
Update Time:2025-08-04

3-(5-fluoro-2-methoxyphenyl)phenol Chemical and Physical Properties

Names and Identifiers

    • 3-(5-fluoro-2-methoxyphenyl)phenol
    • 5'-Fluoro-2'-methoxy[1,1'-biphenyl]-3-ol
    • AKOS017550620
    • 3-(5-Fluoro-2-methoxyphenyl)phenol, 95%
    • 1225773-98-7
    • DTXSID30680819
    • MFCD16484437
    • MDL： MFCD16484437
    • Inchi： 1S/C13H11FO2/c1-16-13-6-5-10(14)8-12(13)9-3-2-4-11(15)7-9/h2-8,15H,1H3
    • InChI Key： ZNAMUVJPEIAWKI-UHFFFAOYSA-N
    • SMILES： FC1C=CC(=C(C=1)C1C=CC=C(C=1)O)OC

Computed Properties

  • Exact Mass: 218.07430775g/mol
  • Monoisotopic Mass: 218.07430775g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 2
  • Complexity: 222
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.3
  • Topological Polar Surface Area: 29.5?2

3-(5-fluoro-2-methoxyphenyl)phenol Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB318809-5 g
3-(5-Fluoro-2-methoxyphenyl)phenol, 95%; .
 1225773-98-7 95%
5g
 €1159.00 2023-04-26
abcr
AB318809-5g
3-(5-Fluoro-2-methoxyphenyl)phenol, 95%; .
 1225773-98-7 95%
5g
 €1159.00 2025-02-21

3-(5-fluoro-2-methoxyphenyl)phenol Related Literature

Additional information on 3-(5-fluoro-2-methoxyphenyl)phenol

Comprehensive Overview of 3-(5-Fluoro-2-Methoxyphenyl)Phenol (CAS No. 1225773-98-7): Properties, Applications, and Industry Insights

3-(5-Fluoro-2-methoxyphenyl)phenol (CAS 1225773-98-7) is a fluorinated aromatic compound gaining attention in pharmaceutical and material science research. This specialty chemical features a unique molecular structure combining a phenol moiety with a fluorinated methoxyphenyl group, making it valuable for designing advanced materials and bioactive molecules. Researchers are increasingly exploring its potential as a building block in drug discovery, particularly for targeting neurological and metabolic disorders.

The compound's fluorine substitution at the 5-position enhances its lipophilicity and metabolic stability, key properties sought after in modern medicinal chemistry. Recent studies suggest its utility in developing PET radiotracers for diagnostic imaging, aligning with the growing demand for precision medicine tools. The methoxy group contributes to its versatility as a synthetic intermediate, enabling diverse chemical modifications for structure-activity relationship studies.

In material science, 3-(5-fluoro-2-methoxyphenyl)phenol serves as a precursor for liquid crystal materials and OLED intermediates, addressing industry needs for high-performance display technologies. Its thermal stability and electronic properties make it suitable for developing organic semiconductors, particularly for flexible electronics applications. The compound's structure-property relationships are being actively investigated to optimize its performance in these cutting-edge applications.

Analytical characterization of CAS 1225773-98-7 typically involves HPLC purification, NMR spectroscopy, and mass spectrometry to ensure high purity standards required for research applications. Recent advancements in continuous flow chemistry have improved its synthetic accessibility, addressing common questions about scale-up challenges for such specialized compounds. Environmental considerations in its synthesis and handling reflect the chemical industry's growing emphasis on green chemistry principles.

The compound's stability profile makes it suitable for various formulation studies, particularly in developing controlled-release drug delivery systems. Researchers are examining its potential as a molecular scaffold for kinase inhibitors, responding to the pharmaceutical industry's need for targeted cancer therapies. Its structure-activity relationships are being mapped using computational chemistry tools, combining QSAR modeling with experimental validation.

Market analysts note increasing demand for fluorinated intermediates like 3-(5-fluoro-2-methoxyphenyl)phenol, driven by expansion in biopharmaceutical R&D and electronic materials sectors. The compound's patent landscape shows growing intellectual property activity, particularly in applications related to neurodegenerative disease therapeutics. Quality control protocols for CAS 1225773-98-7 emphasize rigorous impurity profiling to meet regulatory requirements for clinical-stage materials.

Emerging applications explore its use in metal-organic frameworks (MOFs) for gas storage and separation technologies. The compound's hydrogen bonding capacity and π-stacking interactions make it interesting for designing functional materials with tailored porosity. These developments align with global initiatives for carbon capture technologies and sustainable energy solutions.

Safety evaluations of 3-(5-fluoro-2-methoxyphenyl)phenol follow standard protocols for laboratory chemicals, with particular attention to proper handling of fluorinated compounds. The scientific community continues to investigate its structure-toxicity relationships through in silico and in vitro methods, reflecting the pharmaceutical industry's focus on early ADMET prediction. These studies contribute valuable data to the growing chemical safety databases used by researchers worldwide.

Future research directions for CAS 1225773-98-7 include exploring its chiral derivatives for asymmetric synthesis applications and investigating its potential in photopharmacology systems. The compound's versatility ensures its continued relevance across multiple scientific disciplines, from medicinal chemistry to advanced materials engineering. As synthetic methodologies evolve, this fluorinated phenol derivative is poised to play an increasingly important role in developing next-generation therapeutic agents and functional materials.

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