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Comprehensive Overview of 2-Chloro-4-(3-methylsulfonylphenyl)benzoic Acid (CAS No. 1261913-06-7)

2-Chloro-4-(3-methylsulfonylphenyl)benzoic Acid (CAS No. 1261913-06-7) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This benzoic acid derivative features a unique molecular structure, combining a chloro-substituted benzene ring with a methylsulfonylphenyl group, making it a valuable intermediate in synthetic chemistry. Its CAS number 1261913-06-7 ensures precise identification in global chemical databases, while its systematic name highlights its structural complexity.

The compound’s chemical properties include a molecular weight of approximately 310.75 g/mol and a melting point range of 180–185°C, which are critical for its handling and application in laboratory settings. Researchers often explore its solubility in organic solvents like dimethyl sulfoxide (DMSO) and methanol, which facilitates its use in reactions such as cross-coupling and esterification. The presence of both electron-withdrawing (chloro and sulfonyl) and electron-donating groups in its structure contributes to its reactivity, enabling diverse synthetic pathways.

In the pharmaceutical industry, 2-Chloro-4-(3-methylsulfonylphenyl)benzoic Acid serves as a key intermediate for developing small-molecule drugs. Its structural motifs are frequently incorporated into compounds targeting inflammatory diseases and metabolic disorders, aligning with current trends in personalized medicine. Recent studies have also investigated its potential in cancer therapeutics, particularly in modulating kinase inhibitors, a hot topic in oncology research.

The agrochemical sector leverages this compound for designing next-generation pesticides and herbicides. Its sulfonyl moiety enhances binding affinity to biological targets, improving efficacy against resistant pests. With growing global emphasis on sustainable agriculture, researchers are optimizing derivatives of CAS 1261913-06-7 to reduce environmental impact while maintaining high crop yields—a priority echoed in EU Green Deal policies.

From a market perspective, demand for 2-Chloro-4-(3-methylsulfonylphenyl)benzoic Acid is driven by its versatility and scalability. Manufacturers in China, India, and Europe dominate production, with stringent quality control measures to meet REACH and FDA standards. Pricing trends reflect its niche status, with bulk procurement favored by contract research organizations (CROs).

Synthetic methodologies for 1261913-06-7 often involve palladium-catalyzed Suzuki-Miyaura coupling or Friedel-Crafts acylation, techniques widely discussed in organic chemistry forums. Innovations in green chemistry, such as solvent-free reactions or biocatalysis, are being explored to align with ESG (Environmental, Social, and Governance) goals—a trending search term among chemical industry professionals.

Analytical characterization of this compound relies on advanced techniques like HPLC, NMR spectroscopy, and mass spectrometry. Purity thresholds (>98%) are critical for end-use applications, prompting rigorous QC protocols. These details are frequently queried in scientific databases such as SciFinder and Reaxys, underscoring the compound’s academic relevance.

In summary, 2-Chloro-4-(3-methylsulfonylphenyl)benzoic Acid (CAS No. 1261913-06-7) exemplifies the intersection of innovation and practical utility in modern chemistry. Its applications span drug discovery, crop protection, and material science, reflecting broader industrial shifts toward sustainability and efficiency. As research evolves, this compound will likely remain a focal point for high-impact scientific inquiries.

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