• 1. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 2. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 3. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 4. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 5. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

2-(3,5-Dicarboxyphenyl)benzoic Acid: A Comprehensive Overview

2-(3,5-Dicarboxyphenyl)benzoic acid, also known by its CAS number 1261893-73-5, is a versatile organic compound with significant applications in various fields. This compound, characterized by its unique structure and functional groups, has garnered attention in recent years due to its potential in advanced materials, pharmaceuticals, and environmental science. This article delves into the properties, synthesis, applications, and the latest research findings related to this compound.

The molecular structure of 2-(3,5-Dicarboxyphenyl)benzoic acid consists of a benzoic acid moiety attached to a 3,5-dicarboxyphenyl group. This arrangement imparts the compound with dual carboxylic acid functionalities, which are pivotal for its reactivity and versatility. The compound exists as a white crystalline solid under standard conditions and exhibits high solubility in polar solvents such as water and methanol. Its molecular weight is approximately 296.2 g/mol, and it has a melting point of around 240°C.

Recent studies have highlighted the importance of 2-(3,5-Dicarboxyphenyl)benzoic acid in the development of advanced materials. Researchers have explored its use as a building block for synthesizing metal-organic frameworks (MOFs) and coordination polymers. These materials exhibit exceptional porosity and stability, making them ideal candidates for gas storage, catalysis, and sensing applications. For instance, a study published in Nature Materials demonstrated that MOFs derived from this compound can efficiently adsorb CO? at ambient conditions, offering a sustainable solution to carbon capture.

In the pharmaceutical industry, 2-(3,5-Dicarboxyphenyl)benzoic acid has shown promise as a precursor for drug delivery systems. Its carboxylic acid groups enable the formation of amide bonds with various bioactive molecules, facilitating the design of targeted drug delivery vehicles. A recent investigation in Bioconjugate Chemistry reported that derivatives of this compound can enhance the bioavailability of anticancer drugs by protecting them from premature degradation in the bloodstream.

The synthesis of 2-(3,5-Dicarboxyphenyl)benzoic acid typically involves multi-step organic reactions. One common approach is the Friedel-Crafts acylation followed by oxidation to introduce the carboxylic acid groups. However, recent advancements have introduced more efficient methodologies. For example, researchers at Stanford University developed a one-pot synthesis using microwave-assisted techniques, which significantly reduces reaction time while maintaining high yields.

Beyond its material and pharmaceutical applications, 2-(3,5-Dicarboxyphenyl)benzoic acid has also found utility in environmental science. Its ability to chelate metal ions makes it a valuable component in water treatment processes. A study published in ) demonstrated that this compound can effectively remove heavy metals such as lead and cadmium from contaminated water sources.

In conclusion, 2-(3,5-Dicarboxyphenyl)benzoic acid, with its CAS number 1261893-73-5, stands as a remarkable example of how organic compounds can bridge multiple scientific disciplines. From advanced materials to drug delivery systems and environmental remediation, this compound continues to inspire innovative research and practical applications. As scientific understanding deepens and new synthesis methods emerge,

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• 7148-03-0(4’-Methylbiphenyl-2-carboxylic Acid)
• 18773-63-2(2-(2-Hydroxymethylphenyl)benzoic Acid)
• 947-84-2(2-Phenylbenzoic acid)
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