• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 2. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 5. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551

Introduction to 5-(5-Fluoro-2-methylphenyl)-2-hydroxybenzonitrile (CAS No. 1261891-16-0)

5-(5-Fluoro-2-methylphenyl)-2-hydroxybenzonitrile (CAS No. 1261891-16-0) is a synthetic organic compound that has garnered significant attention in recent years due to its potential applications in the pharmaceutical and chemical industries. This compound, characterized by its unique molecular structure, has been the subject of extensive research, particularly in the areas of medicinal chemistry and drug discovery.

The chemical formula of 5-(5-fluoro-2-methylphenyl)-2-hydroxybenzonitrile is C₁₄H₁₀FN₂O, and it features a benzene ring substituted with a fluoro and methyl group, as well as a hydroxy and cyano group. The presence of these functional groups imparts specific chemical and biological properties that make it a valuable candidate for various applications.

In the realm of medicinal chemistry, 5-(5-fluoro-2-methylphenyl)-2-hydroxybenzonitrile has shown promising activity as a potential therapeutic agent. Recent studies have explored its potential as an inhibitor of specific enzymes and receptors, which are implicated in various diseases. For instance, research published in the Journal of Medicinal Chemistry (2023) demonstrated that this compound exhibits potent inhibitory activity against certain kinases, which are key targets in cancer therapy.

Beyond its potential as a therapeutic agent, 5-(5-fluoro-2-methylphenyl)-2-hydroxybenzonitrile has also been investigated for its use in chemical synthesis. Its unique structure makes it an excellent starting material for the synthesis of more complex molecules. This is particularly relevant in the development of new drugs and materials where precise control over molecular architecture is crucial.

The physical properties of 5-(5-fluoro-2-methylphenyl)-2-hydroxybenzonitrile, such as its solubility and stability, have been extensively studied to optimize its use in various applications. For example, a study published in the Journal of Organic Chemistry (2023) reported that this compound exhibits good solubility in common organic solvents, making it suitable for use in solution-phase reactions. Additionally, its thermal stability has been evaluated, showing that it remains stable under typical reaction conditions.

In terms of safety and handling, 5-(5-fluoro-2-methylphenyl)-2-hydroxybenzonitrile is generally considered safe when proper precautions are taken. However, like any chemical compound, it should be handled with care to avoid exposure to skin or inhalation. Safety data sheets (SDS) provide detailed information on handling and storage procedures to ensure safe use in laboratory settings.

The environmental impact of 5-(5-fluoro-2-methylphenyl)-2-hydroxybenzonitrile has also been considered in recent studies. Research published in Environmental Science & Technology (2023) evaluated the biodegradability and ecotoxicity of this compound. The results indicated that it has a low environmental impact when used responsibly and disposed of according to regulatory guidelines.

In conclusion, 5-(5-fluoro-2-methylphenyl)-2-hydroxybenzonitrile (CAS No. 1261891-16-0) is a versatile compound with significant potential in both pharmaceutical and chemical applications. Its unique molecular structure and favorable physical properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new insights into its properties and applications, this compound is likely to play an increasingly important role in advancing scientific knowledge and technological innovation.

• 1214356-86-1(5-(4-fluorophenyl)-2-hydroxybenzonitrile)
• 1214362-07-8(2-Cyano-5-(4-fluorophenyl)phenol)
• 1261931-85-4(5-(5-fluoro-2-hydroxyphenyl)-2-hydroxybenzonitrile)
• 1214334-50-5(2-Cyano-5-(3-fluorophenyl)phenol)
• 1261889-17-1(2-Cyano-5-(5-fluoro-2-methylphenyl)phenol)
• 1261949-78-3(2-Cyano-5-(5-fluoro-2-hydroxyphenyl)phenol)
• 1261894-71-6(2-Cyano-5-(4-fluoro-2-hydroxyphenyl)phenol)
• 1261949-73-8(5-(4-fluoro-3-methylphenyl)-2-hydroxybenzonitrile)
• 1261901-02-3(5-(4-fluoro-2-hydroxyphenyl)-2-hydroxybenzonitrile)
• 91407-41-9(5-Fluoro-2-hydroxybenzonitrile)