Cas no 1261797-30-1 (2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol)

2-Fluoro-4-[4-(trifluoromethoxy)phenyl]phenol is a fluorinated aromatic compound featuring both fluorine and trifluoromethoxy substituents, which enhance its electronic and steric properties. This structure makes it a valuable intermediate in pharmaceutical and agrochemical synthesis, particularly in the development of bioactive molecules. The presence of fluorine atoms improves metabolic stability and lipophilicity, while the trifluoromethoxy group contributes to unique reactivity and binding interactions. Its high purity and well-defined structure ensure consistent performance in cross-coupling reactions and other synthetic applications. The compound is typically handled under controlled conditions due to its sensitivity, making it suitable for specialized organic synthesis and research in medicinal chemistry.
2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol structure
1261797-30-1 structure
Product Name:2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol
CAS No:1261797-30-1
MF:C13H8F4O2
MW:272.195037841797
MDL:MFCD18314017
CID:1219558
PubChem ID:53219694
Update Time:2025-05-21

2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol Chemical and Physical Properties

Names and Identifiers

    • 2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol
    • MFCD18314017
    • 2-Fluoro-4-(4-trifluoromethoxyphenyl)phenol, 95%
    • 3-Fluoro-4'-(trifluoromethoxy)[1,1'-biphenyl]-4-ol
    • 2-FLUORO-4-(4-TRIFLUOROMETHOXYPHENYL)PHENOL
    • DTXSID70684518
    • QWOYYCGWGQPVTI-UHFFFAOYSA-N
    • 1261797-30-1
    • MDL： MFCD18314017
    • Inchi： 1S/C13H8F4O2/c14-11-7-9(3-6-12(11)18)8-1-4-10(5-2-8)19-13(15,16)17/h1-7,18H
    • InChI Key： QWOYYCGWGQPVTI-UHFFFAOYSA-N
    • SMILES： FC1=C(C=CC(=C1)C1C=CC(=CC=1)OC(F)(F)F)O

Computed Properties

  • Exact Mass: 272.04604214g/mol
  • Monoisotopic Mass: 272.04604214g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 2
  • Complexity: 287
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.5
  • Topological Polar Surface Area: 29.5?2

2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
A011011617-250mg
3-Fluoro-4-hydroxy-4'-(trifluoromethoxy)biphenyl
 1261797-30-1 97%
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3-Fluoro-4-hydroxy-4'-(trifluoromethoxy)biphenyl
 1261797-30-1 97%
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abcr
AB320054-5 g
2-Fluoro-4-(4-trifluoromethoxyphenyl)phenol, 95%; .
 1261797-30-1 95%
5g
 €1159.00 2023-04-26
abcr
AB320054-5g
2-Fluoro-4-(4-trifluoromethoxyphenyl)phenol, 95%; .
 1261797-30-1 95%
5g
 €1159.00 2025-02-21

2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol Related Literature

Related Categories

Additional information on 2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol

Comprehensive Overview of 2-Fluoro-4-[4-(Trifluoromethoxy)Phenyl]Phenol (CAS No. 1261797-30-1)

2-Fluoro-4-[4-(trifluoromethoxy)phenyl]phenol (CAS No. 1261797-30-1) is a fluorinated aromatic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. The presence of both fluoro and trifluoromethoxy groups enhances its electronic and steric characteristics, making it a valuable intermediate in the synthesis of bioactive molecules. Researchers are increasingly exploring its applications in drug discovery, particularly in the development of kinase inhibitors and antimicrobial agents.

The compound's molecular structure features a phenol core substituted with a fluoro group at the 2-position and a 4-(trifluoromethoxy)phenyl moiety at the 4-position. This arrangement contributes to its lipophilicity and metabolic stability, which are critical factors in medicinal chemistry. Recent studies highlight its potential in targeting G-protein-coupled receptors (GPCRs), a hot topic in drug development due to their role in treating diseases like diabetes and CNS disorders.

In the context of green chemistry, 2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol has been investigated for its compatibility with sustainable synthesis methods. With growing interest in environmentally friendly processes, researchers are optimizing its production using catalytic fluorination and microwave-assisted reactions. These advancements align with the global push toward reducing hazardous waste and energy consumption in chemical manufacturing.

Another area of interest is the compound's role in material science. Its aromatic and fluorinated structure makes it a candidate for designing advanced polymers and liquid crystals. For instance, it could be incorporated into OLED materials, a trending topic due to the demand for high-efficiency displays. The trifluoromethoxy group in particular improves thermal stability, a key requirement for electronic applications.

From an analytical chemistry perspective, CAS No. 1261797-30-1 poses challenges and opportunities in detection and quantification. Techniques like HPLC-MS and NMR spectroscopy are commonly employed to characterize its purity and stability. These methods are frequently searched by professionals seeking quality control protocols for fluorinated compounds.

Given the rising demand for precision medicine, 2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol is also being studied for its potential in personalized therapeutics. Its ability to modulate specific biological pathways makes it a promising candidate for tailored drug formulations, a subject of intense research in oncology and immunology.

In summary, 2-fluoro-4-[4-(trifluoromethoxy)phenyl]phenol (CAS No. 1261797-30-1) is a versatile compound with applications spanning pharmaceuticals, agrochemicals, and advanced materials. Its unique chemical properties and alignment with industry trends ensure its continued relevance in scientific and industrial communities.

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