• 1. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 2. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 3. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 4. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl cyanides

Comprehensive Overview of (2-Amino-5-iodo-phenyl)-acetonitrile (CAS No. 1261758-49-9) and Its Applications

(2-Amino-5-iodo-phenyl)-acetonitrile (CAS No. 1261758-49-9) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research. This compound, characterized by its amino and iodo functional groups, serves as a versatile intermediate in the synthesis of complex molecules. Its unique structure makes it valuable for applications in drug discovery, particularly in the development of targeted therapies and small-molecule inhibitors.

In recent years, the demand for iodinated aromatic compounds like (2-Amino-5-iodo-phenyl)-acetonitrile has surged due to their role in radiopharmaceuticals and imaging agents. Researchers are increasingly exploring its potential in cancer diagnostics and therapeutic agents, aligning with the growing focus on precision medicine. The compound's ability to act as a building block for heterocyclic synthesis further enhances its utility in medicinal chemistry.

The synthesis of (2-Amino-5-iodo-phenyl)-acetonitrile involves precise organic transformations, often starting from commercially available precursors. Its nitrile group offers reactivity for further functionalization, making it a key player in multi-step synthesis workflows. This adaptability is crucial for laboratories focusing on high-throughput screening and lead optimization in drug development.

From an industrial perspective, CAS No. 1261758-49-9 is often discussed in the context of green chemistry and sustainable synthesis. With increasing regulatory pressure on environmentally friendly processes, manufacturers are optimizing routes to produce this compound with minimal waste. This aligns with the broader trend of green pharmaceuticals, a topic frequently searched by professionals in the field.

Another area of interest is the compound's stability and storage conditions. Proper handling of (2-Amino-5-iodo-phenyl)-acetonitrile ensures its longevity and efficacy in research settings. FAQs often revolve around its solubility in common solvents like DMSO or ethanol, as well as its compatibility with metal-catalyzed reactions.

In summary, (2-Amino-5-iodo-phenyl)-acetonitrile (CAS No. 1261758-49-9) is a pivotal compound in modern chemical research. Its applications span from drug discovery to material science, driven by its structural flexibility and reactivity. As the scientific community continues to explore its potential, this compound remains a subject of cutting-edge studies and innovative applications.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)