• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 2. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696

Comprehensive Guide to 2-Bromo-6-iodobenzyl bromide (CAS No. 1261498-12-7): Properties, Applications, and Industry Insights

2-Bromo-6-iodobenzyl bromide (CAS No. 1261498-12-7) is a highly versatile halogenated aromatic compound widely utilized in pharmaceutical intermediates, agrochemical synthesis, and advanced material research. With the increasing demand for halogenated benzyl derivatives in cross-coupling reactions and organocatalysis, this compound has garnered significant attention from researchers and industry professionals alike. Its unique molecular structure, featuring both bromo and iodo substituents, enables selective functionalization—a critical feature for modern drug discovery pipelines.

The compound’s dual-halogen design (2-bromo-6-iodo configuration) positions it as a key building block for Suzuki-Miyaura coupling and Buchwald-Hartwig amination, two of the most searched reaction types in synthetic chemistry databases. Recent studies highlight its role in optimizing heterocyclic compound synthesis, a trending topic in medicinal chemistry forums. Researchers particularly value its stability under inert atmospheres and compatibility with Grignard reagents, making it a staple in high-throughput screening labs.

From an industrial perspective, 2-Bromo-6-iodobenzyl bromide addresses growing needs in LED material engineering and liquid crystal displays (LCDs), where halogenated aromatics improve thermal stability. Environmental concerns around halogen waste have also spurred innovations in recycling byproducts of this compound—a hot topic in green chemistry circles. Analytical techniques like HPLC purity testing and NMR spectral analysis (common search queries) are essential for quality control during its production.

Supply chain analysts note rising procurement of CAS No. 1261498-12-7 by Asian electronic manufacturers, correlating with regional investments in organic semiconductors. Meanwhile, patent filings reveal novel applications in photoredox catalysis—a technique dominating recent American Chemical Society (ACS) publications. Storage recommendations typically emphasize desiccated environments below 4°C to preserve the compound’s reactivity, a detail frequently queried by laboratory technicians.

In academic settings, 2-Bromo-6-iodobenzyl bromide serves as a model substrate for teaching C-X bond activation mechanisms. Its crystalline form (often requested in Sigma-Aldrich product reviews) facilitates X-ray diffraction studies. With global market projections for halogenated intermediates exceeding $2.1 billion by 2026, this compound’s role in high-value chemical manufacturing remains undisputed. Ongoing research explores its derivatization for bioconjugation techniques—another rising trend in proteomics research.

For synthetic chemists, the compound’s electron-withdrawing effects (a frequently debated topic in StackExchange Chemistry threads) enable precise control over aromatic substitution patterns. Regulatory databases confirm its compliance with major REACH and FDA guidelines for research use. As computational chemists increasingly rely on DFT calculations to predict its reactivity, demand for ultra-high-purity grades (≥98%) continues to climb—reflecting broader shifts toward precision synthesis methodologies.

• 885681-96-9(4-Bromo-2-iodobenzyl bromide)
• 856668-67-2(BENZENE, 5-BROMO-1-(BROMOMETHYL)-2-IODO-3-METHYL-)
• 1168153-28-3
• 124312-44-3(Benzene, 2-bromo-4-iodo-1,3,5-trimethyl-)
• 495414-06-7(4-Bromo-2-(bromomethyl)-1-iodobenzene)
• 289617-98-7(1-bromo-2-(bromomethyl)-4-iodobenzene)
• 689260-61-5(Benzene, 5-bromo-1,3-bis(bromomethyl)-2-iodo-)
• 1261757-20-3(2-Bromo-3-iodobenzylbromide)
• 699119-05-6(1-bromo-4-iodo-2,5-dimethyl-benzene)
• 97456-81-0(1-Bromo-3-iodo-2-methylbenzene)