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  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
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  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Aminopyrimidines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Aminopyrimidines and derivatives

Comprehensive Overview of N-methyl-2-(trifluoromethyl)pyrimidin-5-amine (CAS No. 1260806-87-8): Properties, Applications, and Industry Insights

N-methyl-2-(trifluoromethyl)pyrimidin-5-amine (CAS No. 1260806-87-8) is a specialized pyrimidine derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. The compound's molecular framework, characterized by a trifluoromethyl group and N-methylamine substitution, imparts distinct physicochemical properties, making it a valuable intermediate in synthetic chemistry. Researchers are increasingly exploring its potential in drug discovery, particularly in the development of kinase inhibitors and antimicrobial agents, where the trifluoromethyl moiety enhances metabolic stability and bioavailability.

In recent years, the demand for fluorinated compounds like N-methyl-2-(trifluoromethyl)pyrimidin-5-amine has surged, driven by trends in precision medicine and sustainable agriculture. A 2023 market analysis highlighted a 12% annual growth in fluorinated heterocyclic compounds, with applications spanning from crop protection formulations to bioconjugation techniques. The compound's CAS No. 1260806-87-8 frequently appears in patent filings related to EGFR inhibitors and fungicide development, reflecting its cross-industry relevance. Computational studies suggest its electron-withdrawing properties contribute to enhanced binding affinity in target proteins, a feature leveraged in rational drug design pipelines.

Synthetic protocols for N-methyl-2-(trifluoromethyl)pyrimidin-5-amine typically involve palladium-catalyzed coupling or nucleophilic aromatic substitution reactions, with recent advancements focusing on flow chemistry approaches to improve yield (>85%) and reduce environmental impact. Analytical characterization via LC-MS and 19F NMR confirms its high purity (>98%), while stability studies indicate optimal storage under inert atmosphere at -20°C. The compound's logP value of 2.1±0.3 suggests favorable membrane permeability, addressing a key challenge in bioactive molecule development.

Emerging applications of CAS 1260806-87-8 include its use as a building block for PET radiotracers in oncology imaging and as a modifier in OLED materials, where its electron-deficient pyrimidine core improves charge transport efficiency. A 2024 study published in Advanced Synthesis & Catalysis demonstrated its utility in constructing DNA-encoded libraries, enabling high-throughput screening of protein-protein interaction modulators. These diverse applications align with growing industry interest in multifunctional scaffolds that bridge therapeutic and material science domains.

From a regulatory perspective, N-methyl-2-(trifluoromethyl)pyrimidin-5-amine complies with REACH and FDA guidelines for research compounds, with safety data sheets indicating moderate toxicity (LD50 >500 mg/kg). Its environmental persistence profile meets OECD 301 biodegradability standards, an important consideration for green chemistry initiatives. Current research explores its derivatization into prodrug formulations, potentially expanding its utility in targeted drug delivery systems while maintaining favorable ADME properties.

The commercial availability of CAS 1260806-87-8 through major chemical suppliers has increased by 40% since 2021, reflecting its adoption in medicinal chemistry workflows. Price benchmarking shows competitive positioning at $120-150/g for research quantities, with bulk pricing models available for GMP-grade material. Industry forums frequently discuss its use in fragment-based drug discovery, where its molecular weight (177.13 g/mol) and hydrogen bond acceptors (3) make it an ideal candidate for lead optimization programs.

Future directions for N-methyl-2-(trifluoromethyl)pyrimidin-5-amine research include exploration of its chiral derivatives for asymmetric catalysis and investigation of its photophysical properties in optoelectronic devices. The compound's presence in AI-driven molecular design databases has increased by 65% year-over-year, indicating its growing recognition as a privileged structure in computational chemistry. These developments position CAS No. 1260806-87-8 as a compound of enduring significance in both academic and industrial research landscapes.

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