Production Method 1

530115-96-9

1257301-28-2

948894-26-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Acetonitrile ,  1,4-Dioxane ;  15 min, 70 °C

Reference

1,4-Benzoxazepine derivatives as PI3K and mTOR inhibitors and their preparation and use for the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 2

530115-96-9

1257301-28-2

948894-26-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Acetonitrile ,  1,4-Dioxane ;  15 min, 70 °C

Reference

Preparation of benzoxazepines as PI3K/mTOR inhibitors useful in the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 3

530115-96-9

1257301-28-2

948894-26-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Acetonitrile ,  1,4-Dioxane ;  15 min, 70 °C

Reference

Preparation of benzoxazepine derivatives for use as mTOR inhibitors and useful in treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 4

530115-96-9

1257301-28-2

948988-53-2

948894-26-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Acetonitrile ,  1,4-Dioxane ;  15 min, 70 °C

Reference

Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use as antitumor agents and manufacture

, World Intellectual Property Organization, , ,

4-Methyl-piperidine-4-carboxylic acid amide hydrochloride Raw materials

• tert-Butyl 4-cyano-4-methylpiperidine-1-carboxylate

4-Methyl-piperidine-4-carboxylic acid amide hydrochloride Preparation Products

• 4-methylpiperidine-4-carbonitrile (948988-53-2)
• 4-Methyl-piperidine-4-carboxylic acid amide hydrochloride (1257301-28-2)
• 4-Methylpiperidine-4-carbonitrile hydrochloride (948894-26-6)

• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248

• 39546-32-2(piperidine-4-carboxamide)
• 1219803-20-9(4-PIPERIDINE-D9-CARBOXAMIDE)
• 39674-99-2(Piperidine-4-carboxamide hydrochloride)
• 1003021-83-7(4-methyl-4-Piperidinecarboxamide)
• 117920-60-2(3-Piperidinecarboxamide,1-methyl-, hydrochloride (1:1))
• 83433-53-8(4-(1-Piperidinyl)piperidine-4-carboxamide)
• 62718-28-9(1-Methylpiperidine-4-carboxamide)
• 1233026-60-2(4-Ethylpiperidine-4-carboxamide)
• 288379-84-0(2-Methyl-2-(piperidin-4-yl)propanamide)
• 88654-15-3(4-Piperidinecarboxamide, 1-ethyl-)