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  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 2. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 3. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-pyridylmethylamines 6-substituted-2-pyridinylmethylamines

Recent Advances in the Application of (5,6-dichloro-2-pyridyl)methanamine (CAS: 1256825-30-5) in Chemical Biology and Pharmaceutical Research

(5,6-dichloro-2-pyridyl)methanamine (CAS: 1256825-30-5) is an emerging chemical scaffold of significant interest in the fields of chemical biology and pharmaceutical research. This heterocyclic amine derivative has recently gained attention due to its versatile applications in drug discovery, particularly as a key intermediate in the synthesis of bioactive molecules targeting various diseases. The compound's unique structural features, including the dichloro-substituted pyridine ring and the reactive amine group, make it a valuable building block for medicinal chemistry.

Recent studies have demonstrated the potential of (5,6-dichloro-2-pyridyl)methanamine in the development of novel kinase inhibitors. A 2023 publication in the Journal of Medicinal Chemistry reported its successful incorporation into selective JAK2 inhibitors, showing promising results in preclinical models of myeloproliferative disorders. The compound's ability to form stable hydrogen bonds with key residues in the ATP-binding pocket of kinases makes it particularly valuable for structure-based drug design approaches.

In the area of antimicrobial research, (5,6-dichloro-2-pyridyl)methanamine has shown potential as a precursor for novel antibacterial agents. A recent study published in Bioorganic & Medicinal Chemistry Letters (2024) described its conversion into quinolone derivatives with potent activity against multidrug-resistant Gram-positive pathogens. The dichloro substitution pattern appears to enhance membrane permeability while maintaining favorable pharmacokinetic properties.

The compound's application extends to neurodegenerative disease research as well. Researchers at several academic institutions have utilized (5,6-dichloro-2-pyridyl)methanamine as a starting material for developing small molecule modulators of α-synuclein aggregation, a key pathological feature in Parkinson's disease. The latest findings suggest that derivatives of this scaffold can effectively disrupt protein misfolding pathways while crossing the blood-brain barrier.

From a synthetic chemistry perspective, recent advances have improved the scalability and efficiency of (5,6-dichloro-2-pyridyl)methanamine production. A 2024 patent application describes a novel catalytic amination process that significantly increases yield while reducing hazardous byproducts. This development is particularly important as demand for this intermediate grows in pharmaceutical manufacturing.

Ongoing research continues to explore new applications for this versatile compound. Current investigations include its potential in targeted protein degradation (PROTACs), where its ability to form stable interactions with E3 ligases makes it an attractive linker component. Additionally, its fluorescence properties are being studied for potential applications in molecular imaging and diagnostic probes.

In conclusion, (5,6-dichloro-2-pyridyl)methanamine (CAS: 1256825-30-5) represents a valuable chemical tool with diverse applications in drug discovery and chemical biology. Its unique structural features and demonstrated biological activities make it a compound of continuing interest to researchers across multiple therapeutic areas. Future research directions will likely focus on expanding its utility in targeted therapies and exploring novel synthetic methodologies for its derivatization.

• 1060815-54-4((3,6-Dichloropyridin-2-yl)methanamine)
• 871826-13-0((5-Chloropyridin-2-yl)methanamine hydrochloride)
• 188637-75-4((6-chloropyridin-2-yl)methanamine)
• 54957-86-7(2,3-Dichloro-6-methylpyridine)
• 496849-97-9(2-Pyridinecarboxamide, 4,5,6-trichloro-)
• 1060815-16-8((4,6-dichloropyridin-2-yl)methanamine)
• 496850-06-7(2-Pyridinecarbothioamide, 4,5,6-trichloro-)
• 185107-64-6(2-Cyano-5,6-dichloropyridine)
• 67938-76-5((5-chloro-2-pyridyl)methanamine)
• 1257535-54-8((5-chloro-2-pyridyl)methanamine dihydrochloride)