• 1. Stable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-pyridylmethylamines

Introduction to (5-Chloro-2-pyridyl)methanamine (CAS No. 67938-76-5)

(5-Chloro-2-pyridyl)methanamine (CAS No. 67938-76-5) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 5-chloro-2-pyridinemethanamine, is a derivative of pyridine, a fundamental heterocyclic aromatic compound. Its unique chemical structure and functional groups make it an attractive candidate for the development of novel pharmaceuticals and chemical intermediates.

The molecular formula of (5-chloro-2-pyridyl)methanamine is C₆H₇ClN₂, and its molecular weight is approximately 144.6 g/mol. The compound features a pyridine ring with a chlorine atom at the 5-position and an amino group attached to the methyl group at the 2-position. This specific arrangement of functional groups imparts unique chemical properties and reactivity, making it a valuable building block in synthetic chemistry.

In recent years, (5-chloro-2-pyridyl)methanamine has been extensively studied for its potential applications in drug discovery and development. One of the key areas of interest is its role as an intermediate in the synthesis of antidepressants and antipsychotics. The amino group in the molecule can be readily modified through various chemical reactions, such as acylation, alkylation, and coupling reactions, to produce a wide range of derivatives with diverse biological activities.

Recent research has highlighted the importance of (5-chloro-2-pyridyl)methanamine in the development of selective serotonin reuptake inhibitors (SSRIs), which are widely used to treat depression and anxiety disorders. The chlorine substituent on the pyridine ring has been shown to enhance the lipophilicity and bioavailability of these compounds, making them more effective in crossing the blood-brain barrier and reaching their target sites.

Beyond its applications in central nervous system (CNS) disorders, (5-chloro-2-pyridyl)methanamine has also shown promise in the development of antimicrobial agents. Studies have demonstrated that derivatives of this compound exhibit potent antibacterial activity against both Gram-positive and Gram-negative bacteria. This property makes it a potential candidate for addressing the growing problem of antibiotic resistance.

In addition to its therapeutic applications, (5-chloro-2-pyridyl)methanamine is also used as a chemical intermediate in various industrial processes. Its reactivity and stability make it suitable for use in the synthesis of dyes, pigments, and other fine chemicals. The compound can be synthesized through several routes, including the reaction of 5-chloro-2-picoline with ammonia or other nitrogen-containing reagents.

The safety profile of (5-chloro-2-pyridyl)methanamine is an important consideration in its use and handling. While it is not classified as a hazardous substance under current regulations, proper precautions should be taken to ensure safe handling and storage. This includes using appropriate personal protective equipment (PPE) and following standard laboratory safety protocols.

In conclusion, (5-chloro-2-pyridyl)methanamine (CAS No. 67938-76-5) is a multifaceted compound with significant potential in both pharmaceutical research and industrial applications. Its unique chemical structure and functional groups make it a valuable tool for scientists working on the development of new drugs and chemical intermediates. As research continues to uncover new properties and applications, this compound is likely to play an increasingly important role in various fields of chemistry and medicine.

• 180748-30-5((4-CHLOROPYRIDIN-2-YL)METHANAMINE)
• 239113-20-3((3,5-Dichloropyridin-2-yl)methanamine hydrochloride)
• 756462-58-5((3,5-dichloropyridin-2-yl)methanamine)
• 500305-98-6((3-Chloropyridin-2-YL)methanamine)
• 871826-13-0((5-Chloropyridin-2-yl)methanamine hydrochloride)
• 342816-31-3((3-Chloropyridin-2-yl)methanamine dihydrochloride)
• 1168139-51-2((3,5-Dichloropyridin-2-yl)methanamine dihydrochloride)
• 114780-09-5((4-Chloropyridin-2-yl)methanamine dihydrochloride)
• 1257535-54-8((5-chloro-2-pyridyl)methanamine dihydrochloride)
• 1060802-06-3((5-chloropyridin-2-yl)methyl(methyl)amine)