Cas no 1256824-90-4 ((6-chloro-5-methylpyridin-3-yl)methanamine)

(6-Chloro-5-methylpyridin-3-yl)methanamine is a versatile pyridine derivative featuring a chloro-methyl substitution pattern and a primary amine functional group. This compound serves as a valuable intermediate in pharmaceutical and agrochemical synthesis, offering reactivity at both the amine and halogenated aromatic positions. The chloro group enhances electrophilic substitution potential, while the methyl substituent contributes to steric and electronic modulation. The primary amine enables further derivatization through condensation, acylation, or reductive amination. Its rigid pyridine core ensures stability, making it suitable for applications requiring heterocyclic scaffolds. The compound is particularly useful in the development of bioactive molecules, including kinase inhibitors and antimicrobial agents, due to its balanced lipophilicity and structural flexibility.
(6-chloro-5-methylpyridin-3-yl)methanamine structure
1256824-90-4 structure
Product Name:(6-chloro-5-methylpyridin-3-yl)methanamine
CAS No:1256824-90-4
MF:C7H9ClN2
MW:156.612760305405
MDL:MFCD18254322
CID:1218243
PubChem ID:53395593
Update Time:2025-06-12

(6-chloro-5-methylpyridin-3-yl)methanamine Chemical and Physical Properties

Names and Identifiers

    • (6-chloro-5-methylpyridin-3-yl)methanamine
    • (6-CHLORO-5-METHYLPYRIDIN-3-YL)METHYLAMINE
    • SCHEMBL1912301
    • AB74569
    • E91391
    • MFCD18254322
    • CS-0194481
    • 1256824-90-4
    • 3-Pyridinemethanamine, 6-chloro-5-methyl-
    • DTXSID80694183
    • EN300-1964880
    • 1-(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANAMINE
    • MDL: MFCD18254322
    • Inchi: 1S/C7H9ClN2/c1-5-2-6(3-9)4-10-7(5)8/h2,4H,3,9H2,1H3
    • InChI Key: LOVAISLEGWJHKF-UHFFFAOYSA-N
    • SMILES: ClC1=C(C)C=C(C=N1)CN

Computed Properties

  • Exact Mass: 156.0454260g/mol
  • Monoisotopic Mass: 156.0454260g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 108
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1
  • Topological Polar Surface Area: 38.9?2

Experimental Properties

  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 273.1±35.0 °C at 760 mmHg
  • Flash Point: 119.0±25.9 °C
  • Vapor Pressure: 0.0±0.6 mmHg at 25°C

(6-chloro-5-methylpyridin-3-yl)methanamine Security Information

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Additional information on (6-chloro-5-methylpyridin-3-yl)methanamine

Comprehensive Overview of (6-chloro-5-methylpyridin-3-yl)methanamine (CAS No. 1256824-90-4): Properties, Applications, and Industry Insights

(6-chloro-5-methylpyridin-3-yl)methanamine, identified by its CAS number 1256824-90-4, is a specialized organic compound gaining attention in pharmaceutical and agrochemical research. This pyridine derivative features a chloro-methyl substitution pattern and a primary amine functional group, making it a versatile intermediate for synthesizing more complex molecules. The compound's unique structure contributes to its reactivity and potential applications in drug discovery and material science.

Recent trends in AI-driven drug discovery and green chemistry have increased interest in compounds like (6-chloro-5-methylpyridin-3-yl)methanamine. Researchers are particularly focused on its potential as a building block for bioactive molecules, with computational chemistry studies suggesting possible interactions with various biological targets. The compound's molecular weight of 156.61 g/mol and moderate polarity make it suitable for diverse synthetic applications while maintaining favorable physicochemical properties.

The synthesis of 1256824-90-4 typically involves multi-step organic reactions, with careful control of reaction conditions to ensure high purity. Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are essential for characterizing this compound. Quality control measures are critical, as even minor impurities can significantly impact downstream applications in medicinal chemistry or material science research.

From a commercial perspective, (6-chloro-5-methylpyridin-3-yl)methanamine has seen growing demand from contract research organizations (CROs) and pharmaceutical developers. Market analysis indicates particular interest from companies working on central nervous system (CNS) therapeutics and antimicrobial agents, where pyridine derivatives often show promising activity. The compound's stability under standard storage conditions (typically 2-8°C in inert atmosphere) contributes to its practicality for industrial applications.

Environmental and safety considerations for CAS 1256824-90-4 follow standard laboratory chemical protocols. While not classified as highly hazardous, proper handling with personal protective equipment (PPE) is recommended. The compound's environmental fate and biodegradation profile are subjects of ongoing research, particularly in the context of green chemistry initiatives and sustainable pharmaceutical manufacturing.

Recent patent literature reveals innovative applications of (6-chloro-5-methylpyridin-3-yl)methanamine in photovoltaic materials and organic electronics, expanding its utility beyond traditional pharmaceutical uses. The compound's electronic properties make it potentially valuable for designing organic semiconductors and charge transport materials, aligning with the growing demand for flexible electronics and next-generation display technologies.

For researchers working with 1256824-90-4, analytical reference standards are increasingly available from specialty chemical suppliers. The development of validated analytical methods for this compound supports quality assurance in both research and production settings. Collaborative efforts between academia and industry continue to explore novel derivatives and applications for this promising chemical scaffold.

The future outlook for (6-chloro-5-methylpyridin-3-yl)methanamine appears positive, with projected growth in demand from both life sciences and advanced materials sectors. As synthetic methodologies improve and new applications emerge, this compound is likely to maintain its position as a valuable tool for chemical innovation. Ongoing research into its structure-activity relationships and material properties will further define its role in various technological applications.

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