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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidones

6-(Propan-2-yl)pyrimidin-4-ol: A Comprehensive Overview

6-(Propan-2-yl)pyrimidin-4-ol, also known by its CAS number CAS No. 124703-81-7, is a heterocyclic organic compound that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the pyrimidine family, which is a class of six-membered aromatic rings containing two nitrogen atoms at positions 1 and 3. The presence of a propan-2-yl group at position 6 and a hydroxyl group at position 4 introduces unique chemical properties and potential applications in drug design and synthesis.

The structure of 6-(Propan-2-yl)pyrimidin-4-ol is characterized by its pyrimidine ring, which is a derivative of pyrimidine with substituents that enhance its reactivity and selectivity. The propan-2-yl group, also known as an isopropyl group, contributes to the molecule's lipophilicity, while the hydroxyl group at position 4 imparts hydrophilic properties. This balance of hydrophilic and lipophilic characteristics makes the compound an interesting candidate for various biological applications.

Recent studies have explored the potential of 6-(Propan-2-yl)pyrimidin-4-ol in medicinal chemistry, particularly in the development of kinase inhibitors. Kinases are enzymes that play critical roles in cell signaling pathways, and their dysregulation is associated with various diseases, including cancer. The ability of this compound to inhibit specific kinases has been investigated through computational modeling and in vitro assays, showing promising results in preclinical models.

In addition to its pharmacological applications, 6-(Propan-2-yl)pyrimidin-4-one (a related compound) has been studied for its potential as a building block in organic synthesis. Its versatility allows for the construction of complex molecular architectures, which can be further functionalized for diverse applications in materials science and biotechnology.

The synthesis of 6-(Propan-2-yl)pyrimidin-4-one typically involves multi-step reactions, including nucleophilic aromatic substitution and cyclization processes. Researchers have optimized these methods to improve yield and purity, making the compound more accessible for large-scale production and subsequent studies.

In terms of physical properties, CAS No. 124703817 exhibits a melting point of approximately 150°C and is soluble in common organic solvents such as dichloromethane and ethanol. Its UV-vis spectrum shows strong absorption bands in the ultraviolet region, indicating its potential use as a chromophore in optoelectronic materials.

The biological activity of 6-(Propan-2-yloxy)pyrimidinone, another derivative, has been explored in recent studies focusing on anti-inflammatory and antioxidant properties. These findings highlight the broader utility of pyrimidine derivatives beyond traditional pharmaceutical applications.

In conclusion, CAS No. 124703817, or 6-(Propan - yl) pyrimidin - ol, represents a valuable compound with diverse applications across multiple disciplines. Ongoing research continues to uncover new insights into its chemical properties and biological functions, positioning it as a key player in future advancements in drug discovery and materials science.

• 139541-35-8(2-amino-6-(tert-butyl)pyrimidin-4(3H)-one)
• 16353-07-4(6-propylpyrimidin-4-ol)
• 7038-75-7(6-Cyclopropylpyrimidin-4-ol)
• 3438-49-1(6-tert-butyl-3,4-dihydropyrimidin-4-one)
• 1256955-63-1(5-methyl-6-(propan-2-yl)pyrimidin-4-ol)
• 66700-33-2(6-tert-butyl-2-methylpyrimidin-4-ol)
• 140201-06-5(4(3H)-Pyrimidinone, 6-(1,1-dimethylethyl)-3-methyl-)
• 73576-32-6(2-amino-6-(propan-2-yl)-3,4-dihydropyrimidin-4-one)
• 124703-78-2(6-Ethylpyrimidin-4-ol)
• 34126-99-3(2-methyl-6-(propan-2-yl)-3,4-dihydropyrimidin-4-one)