Cas no 1245772-66-0 (1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine)
1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine is a fluorinated pyrazole derivative with notable applications in pharmaceutical and agrochemical research. Its difluoromethyl group enhances metabolic stability and bioavailability, making it a valuable intermediate in the synthesis of biologically active compounds. The presence of the amine functionality at the 4-position allows for further derivatization, enabling the development of targeted molecules. This compound exhibits favorable physicochemical properties, including improved lipophilicity and resistance to enzymatic degradation. Its structural features make it particularly useful in the design of enzyme inhibitors and receptor modulators. Researchers value this scaffold for its versatility in medicinal chemistry and crop protection applications.
1245772-66-0 structure
Product Name:1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine
CAS No:1245772-66-0
MF:C5H7F2N3
MW:147.125987291336
MDL:MFCD15976404
CID:4690970
PubChem ID:50896549
Update Time:2025-10-14
1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine Chemical and Physical Properties
Names and Identifiers
-
- 1-(difluoromethyl)-5-methyl-1H-pyrazol-4-amine
- 1-(difluoromethyl)-5-methylpyrazole-4-ylamine
- STL414848
- SBB073370
- ST45255970
- 1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine
-
- MDL： MFCD15976404
- Inchi： 1S/C5H7F2N3/c1-3-4(8)2-9-10(3)5(6)7/h2,5H,8H2,1H3
- InChI Key： KWEDSDOSHMXMQG-UHFFFAOYSA-N
- SMILES： FC(N1C(C)=C(C=N1)N)F
Computed Properties
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 10
- Rotatable Bond Count: 1
- Complexity: 120
- Topological Polar Surface Area: 43.8
1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Ambeed | A811335-1g |
1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine |
1245772-66-0 | 97% | 1g |
$1295.0 | 2024-04-25 | |
| Chemenu | CM490361-1g |
1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine |
1245772-66-0 | 97% | 1g |
$440 | 2022-06-13 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1350409-50mg |
1-(Difluoromethyl)-5-methyl-1h-pyrazol-4-amine |
1245772-66-0 | 97% | 50mg |
￥14081.00 | 2024-08-09 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1350409-100mg |
1-(Difluoromethyl)-5-methyl-1h-pyrazol-4-amine |
1245772-66-0 | 97% | 100mg |
￥14736.00 | 2024-08-09 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1350409-250mg |
1-(Difluoromethyl)-5-methyl-1h-pyrazol-4-amine |
1245772-66-0 | 97% | 250mg |
￥13192.00 | 2024-08-09 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1350409-500mg |
1-(Difluoromethyl)-5-methyl-1h-pyrazol-4-amine |
1245772-66-0 | 97% | 500mg |
￥14929.00 | 2024-08-09 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1350409-1g |
1-(Difluoromethyl)-5-methyl-1h-pyrazol-4-amine |
1245772-66-0 | 97% | 1g |
￥16752.00 | 2024-08-09 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1350409-2.5g |
1-(Difluoromethyl)-5-methyl-1h-pyrazol-4-amine |
1245772-66-0 | 97% | 2.5g |
￥35175.00 | 2024-08-09 | |
| Enamine | EN300-232441-0.05g |
1-(difluoromethyl)-5-methyl-1H-pyrazol-4-amine |
1245772-66-0 | 95% | 0.05g |
$559.0 | 2024-06-20 | |
| Enamine | EN300-232441-0.1g |
1-(difluoromethyl)-5-methyl-1H-pyrazol-4-amine |
1245772-66-0 | 95% | 0.1g |
$585.0 | 2024-06-20 |
1-(Difluoromethyl)-5-methyl-1H-pyrazol-4-amine Related Literature
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Robert P. Davies,Maria A. Giménez,Laura Patel,Andrew J. P. White Dalton Trans., 2008, 5705-5707
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Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
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5. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
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