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  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

4,4-Difluoro-2-methylpiperidine Hydrochloride (CAS No. 1234616-37-5): A Comprehensive Overview

4,4-Difluoro-2-methylpiperidine Hydrochloride (CAS No. 1234616-37-5) is a fluorinated piperidine derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique difluoromethyl and methyl substitutions, serves as a versatile building block in organic synthesis. Its molecular structure, C6H12F2N·HCl, offers a balance of lipophilicity and metabolic stability, making it valuable for drug discovery.

The growing interest in fluorinated compounds like 4,4-Difluoro-2-methylpiperidine Hydrochloride stems from their ability to modulate biological activity. Researchers frequently search for "fluorinated piperidine applications" or "difluoromethyl piperidine synthesis," reflecting the demand for innovative synthetic routes. This compound’s hydrochloride salt form enhances solubility, a critical factor in formulation development.

In pharmaceutical applications, 4,4-Difluoro-2-methylpiperidine Hydrochloride is explored as a precursor for central nervous system (CNS) therapeutics. Its structural motifs align with trends in "blood-brain barrier permeability" optimization, a hot topic in neurology research. The methyl group at the 2-position contributes to steric effects, influencing receptor binding—a detail often queried in "piperidine SAR studies."

The agrochemical sector leverages this compound for developing crop protection agents. Searches like "fluorinated pesticides 2024" highlight industry interest. Its difluoro moiety resists enzymatic degradation, prolonging field efficacy—a key advantage discussed in "sustainable agrochemical design" forums.

Synthetic methodologies for 4,4-Difluoro-2-methylpiperidine Hydrochloride often involve reductive amination or ring-closing strategies, with recent patents emphasizing "catalyst-free piperidine synthesis." Analytical characterization typically employs NMR and HPLC-MS, addressing common queries about "fluorine NMR chemical shifts."

Market analyses indicate rising demand for high-purity 4,4-Difluoro-2-methylpiperidine HCl, driven by preclinical drug development. Suppliers increasingly address "GMP-grade piperidine derivatives" requirements, reflecting regulatory trends. Storage recommendations emphasize anhydrous conditions to maintain stability—frequently searched as "hydrochloride salt hygroscopicity."

Environmental considerations shape modern applications of 4,4-Difluoro-2-methylpiperidine Hydrochloride. Researchers investigate "biodegradable fluorochemicals" while maintaining efficacy, aligning with "green chemistry principles." Its low ecotoxicity profile compared to older fluorinated compounds makes it preferable for sustainable development.

Future directions include exploring 4,4-Difluoro-2-methylpiperidine Hydrochloride in "proteolysis-targeting chimeras (PROTACs)"—a trending search term. Its ability to serve as a spacer moiety in bifunctional molecules opens new therapeutic avenues, particularly in "targeted protein degradation" strategies gaining traction in oncology research.

• 144230-52-4(4,4-Difluoropiperidine hydrochloride)
• 1364631-70-8(4,4-difluoro-1-(4-piperidyl)piperidine;dihydrochloride)
• 1379258-01-1(D454268)
• 1254104-06-7(3,3-Difluoro-8-azabicyclo[3.2.1]octane hydrochloride)
• 1646908-39-5(Piperidine, 4,4-difluoro-2,2,6,6-tetramethyl-)
• 1445951-07-4(3,3-difluoro-N-methyl-cyclobutanamine;hydrochloride)
• 1780950-86-8(5,5-Difluoro-2-methylpiperidine hydrochloride)
• 1378571-68-6(4,4-Difluoro-2-methylpiperidine hydrochloride)
• 1638768-09-8(4-fluoro-2-methyl-piperidine;hydrochloride)
• 1234616-11-5(3,3-difluoro-8-azabicyclo[3.2.1]octane)