• 1. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 4. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

5-Bromo-2-fluoropyridin-4-amine: An Overview of a Versatile Heterocyclic Compound

5-Bromo-2-fluoropyridin-4-amine (CAS No. 1232430-97-5) is a heterocyclic compound that has garnered significant attention in recent years due to its potential applications in pharmaceutical and chemical research. This compound is characterized by its unique substitution pattern, featuring a bromine atom at the 5-position, a fluorine atom at the 2-position, and an amino group at the 4-position of the pyridine ring. These functional groups endow 5-Bromo-2-fluoropyridin-4-amine with a diverse range of chemical properties and reactivity, making it a valuable intermediate in the synthesis of various bioactive molecules.

The structural versatility of 5-Bromo-2-fluoropyridin-4-amine has been leveraged in the development of novel therapeutic agents. Recent studies have highlighted its potential as a building block for the synthesis of drugs targeting specific biological pathways. For instance, researchers have explored its use in the design of inhibitors for kinases, enzymes that play crucial roles in cellular signaling and disease progression. The bromine and fluorine substituents provide opportunities for fine-tuning the pharmacological properties of derived compounds, such as their solubility, metabolic stability, and target selectivity.

In addition to its applications in drug discovery, 5-Bromo-2-fluoropyridin-4-amine has also been investigated for its utility in chemical biology. Its reactivity with various functional groups allows it to serve as a versatile scaffold for the synthesis of probes and tools used in cellular studies. For example, it can be incorporated into fluorescent tags or affinity labels to monitor protein interactions and dynamics within living cells. This capability has broadened its relevance in both academic and industrial settings.

The synthetic accessibility of 5-Bromo-2-fluoropyridin-4-amine has further contributed to its popularity among chemists. Several efficient synthetic routes have been developed to produce this compound on both laboratory and industrial scales. One notable method involves the bromination and fluorination of pyridine followed by an amination step. These synthetic strategies not only ensure high yields but also allow for easy modification of the substituents, facilitating the exploration of structure-activity relationships (SAR) in drug design.

Recent advancements in computational chemistry have also enhanced our understanding of the properties and behavior of 5-Bromo-2-fluoropyridin-4-amine. Molecular modeling studies have provided insights into its electronic structure, conformational flexibility, and interactions with biological targets. These computational tools are invaluable for predicting the behavior of derived compounds and optimizing their therapeutic potential.

In conclusion, 5-Bromo-2-fluoropyridin-4-amine (CAS No. 1232430-97-5) is a highly versatile heterocyclic compound with significant potential in pharmaceutical and chemical research. Its unique substitution pattern and reactivity make it an attractive intermediate for the synthesis of bioactive molecules, probes, and tools. As research continues to uncover new applications and optimize synthetic methods, 5-Bromo-2-fluoropyridin-4-amine is poised to play an increasingly important role in advancing our understanding and treatment of various diseases.

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• 1364917-17-8(3-Bromo-2-fluoropyridin-4-amine)
• 1364917-13-4(3,5-dibromo-2-fluoro-pyridin-4-amine)
• 2645419-65-2(3-bromo-2-fluoro-5-(methyl-d3)pyridin-4-amine)
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