Cas no 123173-60-4 (2,3-Difluoro-4-nitrophenol)

2,3-Difluoro-4-nitrophenol structure
2,3-Difluoro-4-nitrophenol structure
Product Name:2,3-Difluoro-4-nitrophenol
CAS No:123173-60-4
MF:C6H3F2NO3
MW:175.089728593826
MDL:MFCD13185572
CID:1040366
PubChem ID:14550743
Update Time:2025-04-20

2,3-Difluoro-4-nitrophenol Chemical and Physical Properties

Names and Identifiers

    • 2,3-Difluoro-4-nitrophenol
    • 2,3-difluoro-4-nitro-Phenol
    • Phenol, 2,3-difluoro-4-nitro-
    • ACMC-20abjg
    • AGN-PC-001S5I
    • ANW-65882
    • CTK0F7583
    • difluoronitrophenol
    • SureCN1283268
    • Y10247
    • SCHEMBL1283268
    • AKOS016005607
    • CS-D1550
    • DB-329563
    • FCCFXVJUDSQIMG-UHFFFAOYSA-N
    • 123173-60-4
    • DTXSID20561603
    • EN300-139444
    • MFCD13185572
    • AS-18659
    • AB92763
    • MDL： MFCD13185572
    • Inchi： 1S/C6H3F2NO3/c7-5-3(9(11)12)1-2-4(10)6(5)8/h1-2,10H
    • InChI Key： FCCFXVJUDSQIMG-UHFFFAOYSA-N
    • SMILES： FC1C(=C(C=CC=1[N+](=O)[O-])O)F

Computed Properties

  • Exact Mass: 175.00809
  • Monoisotopic Mass: 175.00809928g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 184
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.6
  • Topological Polar Surface Area: 66?2

Experimental Properties

  • Density: 1.619
  • PSA: 63.37

2,3-Difluoro-4-nitrophenol Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
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 123173-60-4 95%
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Chemenu
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 123173-60-4 95%
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Apollo Scientific
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2,3-Difluoro-4-nitrophenol Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Potassium fluoride ,  1-Chloro-2,3-difluoro-5-nitrobenzene ,  2-Chloro-3,4-difluoro-1-nitrobenzene Catalysts: Tetramethylammonium chloride Solvents: DMSO-d6 ;  7 h, 130 - 135 °C
2.1 Reagents: Potassium hydroxide Solvents: DMSO-d6 ,  Water ;  2 h, 18 - 20 °C; 6 h, 18 - 22 °C
2.2 Reagents: Water ;  0 - 5 °C
2.3 Reagents: Hydrochloric acid Solvents: Water ;  2 h, pH 1, 0 - 5 °C
Reference
Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks
Volchkov, N. V.; et al, Russian Chemical Bulletin, 2021, 70(11), 2156-2163

Production Method 2

Reaction Conditions
1.1 10 h, 495 - 505 °C
2.1 Reagents: Chlorine Catalysts: Iron chloride (FeCl3) Solvents: Chloroform ;  10 h, 25 - 35 °C; 2 h, 30 - 35 °C
3.1 Reagents: Sodium hydroxide Catalysts: Benzyltriethylammonium chloride Solvents: Water ;  2 h, 25 - 45 °C; 5 h, 85 - 95 °C
4.1 Reagents: Sulfuric acid ,  Fuming nitric acid ;  1 h, 10 - 15 °C; 2 h, 15 - 20 °C
5.1 Reagents: Potassium fluoride ,  1-Chloro-2,3-difluoro-5-nitrobenzene ,  2-Chloro-3,4-difluoro-1-nitrobenzene Catalysts: Tetramethylammonium chloride Solvents: DMSO-d6 ;  7 h, 130 - 135 °C
6.1 Reagents: Potassium hydroxide Solvents: DMSO-d6 ,  Water ;  2 h, 18 - 20 °C; 6 h, 18 - 22 °C
6.2 Reagents: Water ;  0 - 5 °C
6.3 Reagents: Hydrochloric acid Solvents: Water ;  2 h, pH 1, 0 - 5 °C
Reference
Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks
Volchkov, N. V.; et al, Russian Chemical Bulletin, 2021, 70(11), 2156-2163

Production Method 3

Reaction Conditions
1.1 Reagents: Potassium hydroxide Solvents: DMSO-d6 ,  Water ;  2 h, 18 - 20 °C; 6 h, 18 - 22 °C
1.2 Reagents: Water ;  0 - 5 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  2 h, pH 1, 0 - 5 °C
Reference
Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks
Volchkov, N. V.; et al, Russian Chemical Bulletin, 2021, 70(11), 2156-2163

Production Method 4

Reaction Conditions
1.1 Reagents: Sulfuric acid ,  Fuming nitric acid ;  1 h, 10 - 15 °C; 2 h, 15 - 20 °C
2.1 Reagents: Potassium fluoride ,  1-Chloro-2,3-difluoro-5-nitrobenzene ,  2-Chloro-3,4-difluoro-1-nitrobenzene Catalysts: Tetramethylammonium chloride Solvents: DMSO-d6 ;  7 h, 130 - 135 °C
3.1 Reagents: Potassium hydroxide Solvents: DMSO-d6 ,  Water ;  2 h, 18 - 20 °C; 6 h, 18 - 22 °C
3.2 Reagents: Water ;  0 - 5 °C
3.3 Reagents: Hydrochloric acid Solvents: Water ;  2 h, pH 1, 0 - 5 °C
Reference
Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks
Volchkov, N. V.; et al, Russian Chemical Bulletin, 2021, 70(11), 2156-2163

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium hydroxide Catalysts: Benzyltriethylammonium chloride Solvents: Water ;  2 h, 25 - 45 °C; 5 h, 85 - 95 °C
2.1 Reagents: Sulfuric acid ,  Fuming nitric acid ;  1 h, 10 - 15 °C; 2 h, 15 - 20 °C
3.1 Reagents: Potassium fluoride ,  1-Chloro-2,3-difluoro-5-nitrobenzene ,  2-Chloro-3,4-difluoro-1-nitrobenzene Catalysts: Tetramethylammonium chloride Solvents: DMSO-d6 ;  7 h, 130 - 135 °C
4.1 Reagents: Potassium hydroxide Solvents: DMSO-d6 ,  Water ;  2 h, 18 - 20 °C; 6 h, 18 - 22 °C
4.2 Reagents: Water ;  0 - 5 °C
4.3 Reagents: Hydrochloric acid Solvents: Water ;  2 h, pH 1, 0 - 5 °C
Reference
Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks
Volchkov, N. V.; et al, Russian Chemical Bulletin, 2021, 70(11), 2156-2163

Production Method 6

Reaction Conditions
1.1 Reagents: Chlorine Catalysts: Iron chloride (FeCl3) Solvents: Chloroform ;  10 h, 25 - 35 °C; 2 h, 30 - 35 °C
2.1 Reagents: Sodium hydroxide Catalysts: Benzyltriethylammonium chloride Solvents: Water ;  2 h, 25 - 45 °C; 5 h, 85 - 95 °C
3.1 Reagents: Sulfuric acid ,  Fuming nitric acid ;  1 h, 10 - 15 °C; 2 h, 15 - 20 °C
4.1 Reagents: Potassium fluoride ,  1-Chloro-2,3-difluoro-5-nitrobenzene ,  2-Chloro-3,4-difluoro-1-nitrobenzene Catalysts: Tetramethylammonium chloride Solvents: DMSO-d6 ;  7 h, 130 - 135 °C
5.1 Reagents: Potassium hydroxide Solvents: DMSO-d6 ,  Water ;  2 h, 18 - 20 °C; 6 h, 18 - 22 °C
5.2 Reagents: Water ;  0 - 5 °C
5.3 Reagents: Hydrochloric acid Solvents: Water ;  2 h, pH 1, 0 - 5 °C
Reference
Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks
Volchkov, N. V.; et al, Russian Chemical Bulletin, 2021, 70(11), 2156-2163

2,3-Difluoro-4-nitrophenol Raw materials

2,3-Difluoro-4-nitrophenol Preparation Products

2,3-Difluoro-4-nitrophenol Related Literature

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