• 1. On molecular complexes derived from amino acids and nicotinamides in combination with boronic acids
  Javier Hernández-Paredes,Ana L. Olvera-Tapia,Jenniffer I. Arenas-García,Herbert H?pfl,Hugo Morales-Rojas,Dea Herrera-Ruiz,Ana I. Gonzaga-Morales,Lourdes Rodríguez-Fragoso CrystEngComm 2015 17 5166
• 2. Heterogeneous catalysis by ultra-small bimetallic nanoparticles surpassing homogeneous catalysis for carbon–carbon bond forming reactions
  Nazgol Norouzi,Mrinmoy K. Das,Alexander J. Richard,Amr A. Ibrahim,Hani M. El-Kaderi,M. Samy El-Shall Nanoscale 2020 12 19191
• 3. Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling
  Samuel Reyes,Robert W. Huigens III,Zhaoming Su,Michel L. Simon,Christian Melander Org. Biomol. Chem. 2011 9 3041

• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

P-(Aminocarbonyl)phenylboronic Acid: A Comprehensive Overview

P-(Aminocarbonyl)phenylboronic acid, also known as p-(aminocarbonyl)phenylboronic acid, is a versatile compound with the CAS number 123088-59-5. This compound has garnered significant attention in the fields of organic chemistry, materials science, and drug discovery due to its unique properties and wide-ranging applications. In this article, we will delve into the structure, synthesis, properties, and latest research findings related to p-(aminocarbonyl)phenylboronic acid.

The molecular structure of p-(aminocarbonyl)phenylboronic acid consists of a phenyl ring substituted with an aminocarbonyl group at the para position and a boronic acid group. This arrangement imparts the compound with both aromatic stability and reactivity, making it an ideal candidate for various chemical transformations. The presence of the boronic acid group allows for Suzuki-Miyaura coupling reactions, a cornerstone in modern organic synthesis. Recent studies have highlighted the use of p-(aminocarbonyl)phenylboronic acid in constructing biaryl compounds, which are crucial in pharmaceuticals and agrochemicals.

One of the most notable advancements involving p-(aminocarbonyl)phenylboronic acid is its role in the development of advanced materials. Researchers have employed this compound in the synthesis of graphene-based composites, where its aromaticity and reactivity contribute to enhanced electronic properties. These materials hold promise for applications in flexible electronics and energy storage devices. Additionally, p-(aminocarbonyl)phenylboronic acid has been utilized in click chemistry protocols, enabling rapid and efficient construction of complex molecules.

Recent research has also focused on the biological applications of p-(aminocarbonyl)phenylboronic acid. Studies have demonstrated its potential as a precursor for bioactive compounds, including anticancer agents and antimicrobial agents. For instance, derivatives of this compound have shown selective cytotoxicity against cancer cells while exhibiting minimal toxicity to healthy cells. Such findings underscore its potential in drug discovery and development.

In terms of synthesis, p-(aminocarbonyl)phenylboronic acid can be prepared via several methods, including nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The choice of synthesis route depends on the desired purity, scalability, and cost-effectiveness. Recent innovations in catalytic systems have further streamlined these processes, making large-scale production more feasible.

Looking ahead, the versatility of p-(aminocarbonyl)phenylboronic acid is expected to drive further exploration into its applications across diverse fields. Its integration into sustainable chemistry practices is particularly promising, as researchers seek greener alternatives for traditional synthetic methods. Moreover, ongoing studies aim to exploit its unique reactivity in developing novel materials with tailored properties for next-generation technologies.

In conclusion, p-(aminocarbonyl)phenylboronic acid stands as a pivotal compound in contemporary chemistry due to its structural versatility and functional diversity. With continuous advancements in synthetic methodologies and material science, this compound is poised to play an increasingly significant role in shaping future innovations across multiple disciplines.

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