Cas no 1227-45-8 (1,3-bis(4-methoxyphenyl)thiourea)

1,3-Bis(4-methoxyphenyl)thiourea is a thiourea derivative characterized by its symmetrical structure featuring methoxy-substituted phenyl groups. This compound is primarily utilized in organic synthesis and coordination chemistry due to its ability to act as a ligand, forming stable complexes with transition metals. The presence of electron-donating methoxy groups enhances its solubility in organic solvents and influences its reactivity in nucleophilic substitution or condensation reactions. It is also investigated for potential applications in materials science, such as polymer stabilization or as a precursor for heterocyclic compounds. The product is typically supplied as a high-purity solid, ensuring consistency in research and industrial applications.
1,3-bis(4-methoxyphenyl)thiourea structure
1227-45-8 structure
Product Name:1,3-bis(4-methoxyphenyl)thiourea
CAS No:1227-45-8
MF:C15H16N2O2S
MW:288.364742279053
MDL:MFCD00025792
CID:168487
PubChem ID:253662055
Update Time:2025-06-09

1,3-bis(4-methoxyphenyl)thiourea Chemical and Physical Properties

Names and Identifiers

    • Thiourea,N,N'-bis(4-methoxyphenyl)-
    • 4,4'-DIMETHOXYTHIOCARBANILIDE
    • 1,3-BIS(4-METHOXYPHENYL)THIOUREA
    • Thiourea, N,N'-bis(4-methoxyphenyl)-
    • 1227-45-8
    • SR-01000005200-2
    • AS-62918
    • AKOS000121526
    • Z45798708
    • C06
    • WLN: 1OR DMYUS&MR DO1
    • Thiourea,N'-bis(4-methoxyphenyl)-
    • DTXSID20153683
    • NSC 164990
    • Oprea1_160503
    • SR-01000005200-1
    • N,N'-Bis(4-methoxyphenyl)thiourea
    • Carbanilide, 4,4'-dimethoxythio-
    • CCG-53869
    • Urea,3-bis(p-methoxyphenyl)-2-thio-
    • B4482
    • MFCD00025792
    • NSC-164990
    • RGRJEERVXALLTH-UHFFFAOYSA-N
    • STK805057
    • SR-01000005200
    • DB-180459
    • Di-p-methoxyphenylthiourea
    • CS-0182196
    • F0207-0869
    • Carbanilide,4'-dimethoxythio-
    • Urea, 1,3-bis(p-methoxyphenyl)-2-thio-
    • Di(p-methoxyphenyl)thiourea
    • BRN 0674430
    • NSC164990
    • SCHEMBL8167087
    • 1,3-bis(4-methoxyphenyl)thiourea
    • MDL: MFCD00025792
    • Inchi: 1S/C15H16N2O2S/c1-18-13-7-3-11(4-8-13)16-15(20)17-12-5-9-14(19-2)10-6-12/h3-10H,1-2H3,(H2,16,17,20)
    • InChI Key: RGRJEERVXALLTH-UHFFFAOYSA-N
    • SMILES: S=C(NC1C=CC(=CC=1)OC)NC1C=CC(=CC=1)OC

Computed Properties

  • Exact Mass: 288.09300
  • Monoisotopic Mass: 288.093248
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 20
  • Rotatable Bond Count: 6
  • Complexity: 270
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.1
  • Topological Polar Surface Area: 74.6

Experimental Properties

  • Density: 1.277
  • Melting Point: 185.0 to 189.0 deg-C
  • Boiling Point: 421.9°Cat760mmHg
  • Flash Point: 209°C
  • Refractive Index: 1.683
  • PSA: 74.61000
  • LogP: 3.65870

1,3-bis(4-methoxyphenyl)thiourea Security Information

  • RTECS:YS2750000
  • Storage Condition:(BD289501)

1,3-bis(4-methoxyphenyl)thiourea Customs Data

  • HS CODE:2930909090
  • Customs Data:

    China Customs Code:

    2930909090

    Overview:

    2930909090. Other organic sulfur compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

1,3-bis(4-methoxyphenyl)thiourea Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B4482-1g
1,3-bis(4-methoxyphenyl)thiourea
1227-45-8 98.0%(LC&N)
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¥1390.0 2022-06-10
TRC
M226785-10mg
1,3-Bis(4-methoxyphenyl)thiourea
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$ 50.00 2022-06-04
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$ 115.00 2022-06-04
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M226785-100mg
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$ 185.00 2022-06-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd.
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1,3-Bis(4-methoxyphenyl)thiourea
1227-45-8 >98.0%(HPLC)(N)
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¥450.00 2024-04-18
eNovation Chemicals LLC
Y0989193-5g
1,3-Bis(4-methoxyphenyl)thiourea
1227-45-8 95%
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$820 2024-08-02
abcr
AB474062-5 g
1,3-Bis(4-methoxyphenyl)thiourea, 98%; .
1227-45-8 98%
5g
€136.90 2023-01-20

Additional information on 1,3-bis(4-methoxyphenyl)thiourea

Comprehensive Overview of 1,3-bis(4-methoxyphenyl)thiourea (CAS No. 1227-45-8): Properties, Applications, and Industry Insights

1,3-bis(4-methoxyphenyl)thiourea (CAS No. 1227-45-8) is a specialized organic compound widely recognized for its unique chemical structure and versatile applications in research and industrial sectors. This thiourea derivative features two 4-methoxyphenyl groups bonded to a central thiocarbonyl group, making it a valuable intermediate in synthetic chemistry. Its molecular formula, C15H16N2O2S, highlights its potential for hydrogen bonding and molecular interactions, which are critical in material science and pharmaceutical development.

In recent years, the demand for high-purity thiourea derivatives like 1,3-bis(4-methoxyphenyl)thiourea has surged due to their role in green chemistry and sustainable synthesis. Researchers are increasingly focusing on eco-friendly alternatives to traditional reagents, and this compound’s ability to act as a catalyst or ligand in metal-organic frameworks (MOFs) aligns with global trends toward reducing chemical waste. A 2023 study highlighted its efficacy in asymmetric catalysis, a hot topic in organic synthesis optimization.

The compound’s thermal stability and solubility in polar solvents such as DMSO and ethanol make it suitable for high-temperature reactions and nanomaterial functionalization. Industries leveraging advanced material engineering often utilize 1227-45-8 to modify polymer matrices or enhance conductive coatings. For instance, its incorporation into photovoltaic materials has been explored to improve solar cell efficiency—a key area of interest given the rise in renewable energy investments.

From an analytical perspective, 1,3-bis(4-methoxyphenyl)thiourea is characterized by techniques like HPLC, NMR spectroscopy, and mass spectrometry. These methods ensure batch-to-batch consistency, a priority for manufacturers addressing quality control challenges. FAQs in scientific forums often inquire about its storage conditions (recommended: 2–8°C under inert gas) and compatibility with other reagents, reflecting user concerns about long-term stability.

Emerging applications include its use in bioconjugation for drug delivery systems, where its thiol-reactive properties enable precise targeting. This aligns with the booming biopharmaceutical market, projected to exceed $500 billion by 2025. Additionally, its low toxicity profile (as per OECD guidelines) makes it a candidate for cosmetic preservatives—a sector increasingly scrutinized for clean-label ingredients.

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