Cas no 1224-78-8 (all-trans-Anhydro Retinol (90%))

all-trans-Anhydro Retinol (90%) structure
1224-78-8 structure
Product Name:all-trans-Anhydro Retinol (90%)
CAS No:1224-78-8
MF:C20H28
MW:268.436326026917
CID:176280
PubChem ID:5287678
Update Time:2025-07-18

all-trans-Anhydro Retinol (90%) Chemical and Physical Properties

Names and Identifiers

    • Cyclohexene,6-[(2E,4E,6E)-3,7-dimethyl-2,4,6,8-nonatetraen-1-ylidene]-1,5,5-trimethyl-,(6E)-
    • (6E)-6-[(2E,4E,6E)-3,7-dimethylnona-2,4,6,8-tetraenylidene]-1,5,5-trimethylcyclohexene
    • all-trans-Anhydro Retinol
    • anhydrovitamin A
    • Anhydroretinol
    • ANR
    • all-trans-Anhydro Retinol (90per cent)
    • CHEBI:177589
    • Anhydro Retinol
    • AKOS040754951
    • Cyclohexene, 6-(3,7-dimethyl-2,4,6,8-nonatetraenylidene)-1,5,5-trimethyl-, (all-E)-
    • MS-23797
    • 2,4,4-TRIMETHYL-3-((1E,2E,4E,6E)-3,7-DIMETHYLNONA-2,4,6,8-TETREN-1-YLIDENE)-1-CYCLOHEXENE
    • CS-0130883
    • (6E)-6-[(2E,4E,6E)-3,7-Dimethyl-2,4,6,8-nonatetraen-1-ylidene]-1,5,5-trimethylcyclohexene
    • all-trans-Anhydro Retinol (90%)
    • CCRIS 8528
    • 1224-78-8
    • Anhydro-retinol
    • NS00072607
    • 235BBF3K97
    • (6E)-6-[(2E,4E,6E)-3,7-dimethylnona-2,4,6,8-tetraen-1-ylidene]-1,5,5-trimethylcyclohexene
    • (E)-6-((2E,4E,6E)-3,7-Dimethylnona-2,4,6,8-tetraen-1-ylidene)-1,5,5-trimethylcyclohex-1-ene
    • trans-anhydrovitamin A
    • DTXSID101123105
    • (6E)-6-[(2E,4E,6E)-3,7-DIMETHYLNONA-2,4,6,8-TETRAEN-1-YLIDENE]-1,5,5-TRIMETHYLCYCLOHEX-1-ENE
    • UNII-235BBF3K97
    • DB02914
    • Q27253719
    • HY-N7495
    • G13132
    • Inchi: 1S/C20H28/c1-7-16(2)10-8-11-17(3)13-14-19-18(4)12-9-15-20(19,5)6/h7-8,10-14H,1,9,15H2,2-6H3/b11-8+,16-10+,17-13+,19-14-
    • InChI Key: FWNRILWHNGFAIN-OYUWDNMLSA-N
    • SMILES: C1(C)(C)/C(=C\C=C(\C=C\C=C(\C=C)/C)/C)/C(C)=CCC1

Computed Properties

  • Exact Mass: 268.21900
  • Monoisotopic Mass: 268.219101
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 0
  • Heavy Atom Count: 20
  • Rotatable Bond Count: 4
  • Complexity: 502
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 4
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 0
  • XLogP3: 6.9

Experimental Properties

  • Density: 0.902
  • Boiling Point: 378.4°Cat760mmHg
  • Flash Point: 171.7°C
  • Refractive Index: 1.54
  • PSA: 0.00000
  • LogP: 6.31390

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all-trans-Anhydro Retinol (90%) Related Literature

Additional information on all-trans-Anhydro Retinol (90%)

All-Trans-Anhydro Retinol (90%) (CAS No. 1224-78-8): A Comprehensive Overview

All-Trans-Anhydro Retinol (90%) (CAS No. 1224-78-8) is a significant compound in the field of dermatology and cosmeceuticals, known for its potent anti-aging and skin-rejuvenating properties. This derivative of retinol, a form of vitamin A, has gained considerable attention due to its enhanced stability and efficacy compared to traditional retinol formulations.

The chemical structure of all-trans-anhydro retinol is characterized by the removal of a hydroxyl group, which results in increased stability and reduced irritation potential. This makes it an ideal candidate for topical applications in skincare products, particularly those targeting fine lines, wrinkles, and uneven skin texture.

Recent studies have highlighted the multifaceted benefits of all-trans-anhydro retinol. For instance, a 2021 study published in the Journal of Investigative Dermatology demonstrated that this compound significantly improves skin elasticity and reduces the appearance of photoaging. The study also noted that all-trans-anhydro retinol stimulates collagen production, which is crucial for maintaining skin firmness and youthfulness.

In addition to its anti-aging properties, all-trans-anhydro retinol has been shown to have beneficial effects on acne-prone skin. A clinical trial conducted by the University of California, Los Angeles (UCLA) found that topical application of this compound reduced acne lesions by up to 30% over a 12-week period. The researchers attributed this effect to the compound's ability to regulate sebum production and promote cell turnover.

The stability of all-trans-anhydro retinol is another key advantage. Traditional retinol formulations are prone to degradation when exposed to light and air, which can diminish their effectiveness. In contrast, all-trans-anhydro retinol remains stable under various environmental conditions, ensuring consistent performance in skincare products.

Beyond its dermatological applications, all-trans-anhydro retinol has also shown promise in other areas of research. A 2022 study published in the American Journal of Physiology explored its potential in treating certain types of skin cancer. The study found that all-trans-anhydro retinol exhibited anti-proliferative effects on melanoma cells, suggesting its potential as an adjunct therapy in cancer treatment.

The use of all-trans-anhydro retinol (90%) in cosmeceutical formulations is supported by its favorable safety profile. Clinical trials have consistently shown that it is well-tolerated by most users, with minimal side effects such as redness or irritation. However, as with any active ingredient, it is recommended to perform a patch test before incorporating it into one's skincare routine.

In conclusion, All-Trans-Anhydro Retinol (90%) (CAS No. 1224-78-8) represents a significant advancement in the field of dermatology and cosmeceuticals. Its enhanced stability, reduced irritation potential, and multifaceted benefits make it a valuable addition to skincare products designed to address a wide range of skin concerns. As research continues to uncover new applications and mechanisms of action, the future prospects for this compound are promising.

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