Cas no 1218791-13-9 (4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester)

4-(Cbz-Amino)-2-fluorophenylboronic acid pinacol ester is a boronic acid derivative widely used in Suzuki-Miyaura cross-coupling reactions. The Cbz (carbobenzyloxy) protecting group enhances stability and facilitates selective deprotection, while the fluorine substituent influences reactivity and electronic properties. The pinacol ester moiety improves handling and shelf life by protecting the boronic acid from protodeboronation. This compound is particularly valuable in pharmaceutical and agrochemical synthesis, where controlled functionalization of aromatic systems is required. Its compatibility with diverse reaction conditions and intermediates makes it a versatile building block for constructing complex molecules. The product is typically supplied as a crystalline solid with high purity, ensuring reliable performance in synthetic applications.

4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester structure

1218791-13-9 structure

Product Name:4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester

CAS No:1218791-13-9

MF:C₂₀H₂₃BFNO₄

MW:371.210329294205

MDL:MFCD11054035

CID:829193

PubChem ID:46738001

Update Time:2025-11-06

4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester Chemical and Physical Properties

Names and Identifiers

- Benzyl (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate
- 4-(Benzyloxycarbonylamino)-2-fluorophenylboronic acid, pinacol ester
- 4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester
- benzyl N-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
- 4-(Benzyloxycarbonylamino)-2-fluorophenylboronic acid, AldrichCPR
- BS-26484
- F82910
- 1218791-13-9
- 4-(Cbz-Amino)-2-fluorophenylboronic acid pinacol ester
- EN300-7358921
- Benzyl [3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
- DTXSID90674158
- AKOS015960258
- benzyl 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate
- benzyl N-[3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
- MFCD11054035
- CS-0176615
- DB-367014
- benzyl (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl)carbamate
- MDL： MFCD11054035
- Inchi： 1S/C20H23BFNO4/c1-19(2)20(3,4)27-21(26-19)16-11-10-15(12-17(16)22)23-18(24)25-13-14-8-6-5-7-9-14/h5-12H,13H2,1-4H3,(H,23,24)
- InChI Key： XPCYDSDRORRCFT-UHFFFAOYSA-N
- SMILES： FC1C=C(C=CC=1B1OC(C)(C)C(C)(C)O1)NC(=O)OCC1C=CC=CC=1

Computed Properties

Exact Mass: 371.17000
Monoisotopic Mass: 371.1704165g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 5
Heavy Atom Count: 27
Rotatable Bond Count: 5
Complexity: 508
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 56.8?2

Experimental Properties

Density: 1.19±0.1 g/cm3 (20 oC 760 Torr),
PSA: 60.28000
LogP: 3.88720

4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester Security Information

Hazard Category Code： 22
Hazardous Material Identification：

4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester Customs Data

HS CODE：2934999090
Customs Data：

China Customs Code:
2934999090

Overview:

2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to

Summary:

2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
TRC	C227080-100mg	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester	1218791-13-9		100mg	$ 64.00	2023-04-18
TRC	C227080-250mg	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester	1218791-13-9		250mg	$ 75.00	2023-04-18
TRC	C227080-500mg	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester	1218791-13-9		500mg	$ 87.00	2023-04-18
TRC	C227080-1g	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester	1218791-13-9		1g	$ 98.00	2023-04-18
Alichem	A019110704-25g	Benzyl (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate	1218791-13-9	95%	25g	$469.68	2023-09-03
Chemenu	CM134839-25g	benzyl (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate	1218791-13-9	95%	25g	$672	2023-01-10
abcr	AB273559-1 g	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester, 95%; .	1218791-13-9	95%	1g	€127.00	2023-04-26
abcr	AB273559-5 g	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester, 95%; .	1218791-13-9	95%	5g	€297.00	2023-04-26
abcr	AB273559-10 g	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester, 95%; .	1218791-13-9	95%	10g	€467.00	2023-04-26
abcr	AB273559-25 g	4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester, 95%; .	1218791-13-9	95%	25g	€807.00	2023-04-26

4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

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(CAS:1218791-13-9)特地唑胺雜質(zhì)16

Order Number:LE26023831

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:54

Price ($):discuss personally

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Additional information on 4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester

Market Research and Analysis Report: 4-(Cbz-Amino)-2-fluorophenylboronic Acid, Pinacol Ester

The compound 4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester (CAS No. 1218791-13-9) has emerged as a significant intermediate in the field of medicinal chemistry and drug discovery. This boronic acid derivative is widely utilized in Suzuki-Miyaura cross-coupling reactions, which are pivotal in the synthesis of complex heterocyclic structures with potential therapeutic applications.

Recent studies have highlighted the role of this compound in the development of novel small-molecule inhibitors targeting various disease pathways, including cancer and neurodegenerative disorders. Its unique structure, featuring a fluoro-substituted aromatic ring and a carbamate-protected amino group, makes it highly versatile for modular synthesis strategies.

Market demand for 4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester has been driven by increasing investments in early-stage drug discovery programs and the growing emphasis on chemical diversity in compound libraries. Key players in the pharmaceutical and biotechnology sectors are actively sourcing this intermediate to support their pipeline projects.

Global suppliers of this product are leveraging advanced synthetic methodologies to ensure consistent quality and scalability. The competitive landscape is characterized by a mix of specialty chemical manufacturers and research-focused organizations, each striving to meet the evolving needs of academic institutions, pharma companies, and contract research organizations (CROs).

From a regulatory perspective, compliance with Good Manufacturing Practices (GMP) and stringent quality control measures remains critical to maintaining trust in the supply chain. As the demand for high-purity intermediates continues to rise, innovation in synthesis routes and purification techniques will be essential to address market needs effectively.

In conclusion, 4-(Cbz-Amino)-2-fluorophenylboronic acid, pinacol ester (CAS No. 1218791-13-9) occupies a strategic position in the landscape of modern drug discovery. Its versatility as a building block for complex molecules positions it as a key enabler for advancing novel therapeutic agents across diverse therapeutic areas.

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