• 1. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 2. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 3. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 4. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509
• 5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylcarbamic acid esters

2-Fluoro-4-(phenoxycarbonylamino)benzeneboronic Acid Pinacol Ester: A Comprehensive Overview

The compound with CAS No. 1245252-62-3, known as 2-Fluoro-4-(phenoxycarbonylamino)benzeneboronic Acid Pinacol Ester, is a highly specialized organic compound that has garnered significant attention in the fields of organic synthesis, medicinal chemistry, and materials science. This compound is a derivative of benzeneboronic acid, featuring a fluoro group at the 2-position and a phenoxycarbonylamino substituent at the 4-position. The pinacol ester functional group further enhances its reactivity and versatility in various chemical reactions.

The benzeneboronic acid core of this compound is a fundamental building block in modern organic chemistry, particularly in Suzuki-Miyaura coupling reactions. These reactions are pivotal in the construction of biaryl structures, which are widely used in drug discovery and materials synthesis. The presence of the fluoro group introduces electronic effects that can modulate the reactivity of the boronic acid moiety, making it an attractive substrate for cross-coupling reactions under mild conditions.

The phenoxycarbonylamino substituent adds another layer of complexity to this molecule. This group is known to enhance solubility and bioavailability, making it particularly relevant in pharmaceutical applications. Recent studies have explored the use of such substituents in improving the pharmacokinetic profiles of drug candidates, underscoring the potential of this compound in medicinal chemistry.

From a synthetic perspective, the preparation of 2-Fluoro-4-(phenoxycarbonylamino)benzeneboronic Acid Pinacol Ester involves a series of carefully orchestrated reactions. The synthesis typically begins with the fluorination of a suitable benzene derivative, followed by the introduction of the phenoxycarbonylamino group via nucleophilic aromatic substitution or other coupling methods. The final step involves the formation of the pinacol ester, which is achieved through boronate esterification using pinacol borane.

Recent advancements in catalytic methods have significantly streamlined the synthesis of such compounds. For instance, the use of palladium catalysts has enabled more efficient Suzuki couplings, reducing reaction times and improving yields. These developments have made compounds like 1245252-62-3 more accessible for large-scale applications in drug discovery and materials science.

In terms of applications, this compound is particularly valuable in the construction of heterocyclic frameworks. Its ability to undergo various cross-coupling reactions makes it an ideal precursor for synthesizing complex molecules with diverse functionalities. For example, researchers have utilized this compound to synthesize novel kinase inhibitors and GPCR modulators, demonstrating its potential in drug development.

The pinacol ester functionality also plays a critical role in enabling controlled release mechanisms in drug delivery systems. By incorporating this group into polymer backbones or nanoparticles, scientists can design systems that release therapeutic agents at specific rates and locations within the body. This has opened new avenues for targeted drug delivery and personalized medicine.

From an analytical standpoint, modern spectroscopic techniques such as NMR and mass spectrometry have been instrumental in confirming the structure and purity of this compound. These tools allow researchers to perform detailed characterization, ensuring that the compound meets rigorous quality standards required for both academic and industrial applications.

In conclusion, CAS No. 1245252-62-3, or 2-Fluoro-4-(phenoxycarbonylamino)benzeneboronic Acid Pinacol Ester, represents a cutting-edge compound with multifaceted applications across various scientific disciplines. Its unique combination of functional groups positions it as a valuable tool in modern organic synthesis and drug discovery. As research continues to uncover new synthetic pathways and applications for this compound, its significance in advancing chemical science will undoubtedly grow.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)