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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes

Comprehensive Overview of (R)-1-(3-Chloro-5-fluorophenyl)ethanamine hydrochloride (CAS No. 1217475-54-1)

(R)-1-(3-Chloro-5-fluorophenyl)ethanamine hydrochloride is a chiral amine derivative with significant applications in pharmaceutical research and organic synthesis. This compound, identified by CAS No. 1217475-54-1, is a hydrochloride salt form of the enantiomerically pure (R)-1-(3-Chloro-5-fluorophenyl)ethanamine. Its unique structural features, including the 3-chloro-5-fluorophenyl moiety and the chiral center, make it a valuable intermediate in the development of bioactive molecules and therapeutic agents.

The growing interest in chiral amines like (R)-1-(3-Chloro-5-fluorophenyl)ethanamine hydrochloride stems from their role in asymmetric synthesis and drug discovery. Researchers are increasingly focusing on enantioselective catalysis and pharmaceutical intermediates, which aligns with the demand for high-purity chiral compounds. This compound's fluorine and chlorine substituents enhance its reactivity and binding affinity, making it a candidate for targeting specific biological pathways.

In the context of AI-driven drug discovery and computational chemistry, CAS No. 1217475-54-1 has garnered attention due to its potential in virtual screening and molecular docking studies. The integration of machine learning in chemical research has accelerated the identification of novel applications for such compounds. For instance, its structural analogs are being explored for their efficacy in central nervous system (CNS) disorders and metabolic diseases, reflecting broader trends in precision medicine.

From a synthetic perspective, the preparation of (R)-1-(3-Chloro-5-fluorophenyl)ethanamine hydrochloride involves asymmetric hydrogenation or enzymatic resolution techniques. These methods are critical for achieving high enantiomeric excess (ee), a key parameter in pharmaceutical manufacturing. The compound's hydrochloride salt form improves its stability and solubility, facilitating its use in formulation studies.

Environmental and green chemistry considerations are also shaping the discourse around this compound. Researchers are investigating sustainable synthesis routes to minimize waste and energy consumption. The halogenated aromatic structure of (R)-1-(3-Chloro-5-fluorophenyl)ethanamine hydrochloride poses challenges in this regard, but advances in catalytic processes offer promising solutions.

In summary, (R)-1-(3-Chloro-5-fluorophenyl)ethanamine hydrochloride (CAS No. 1217475-54-1) exemplifies the intersection of chiral chemistry, drug development, and sustainable innovation. Its versatility and relevance to cutting-edge research ensure its continued prominence in the scientific community.

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