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• Solvents and Organic Chemicals Organic Compounds Organic Polymers Polypeptides Polypeptides
• Solvents and Organic Chemicals Organic Compounds Organic Polymers Polypeptides

Comprehensive Analysis of Protein Kinase C (19-31) (CAS No. 121545-65-1): Structure, Function, and Research Applications

The Protein Kinase C (19-31) peptide, with the CAS No. 121545-65-1, is a biologically active fragment derived from the regulatory domain of Protein Kinase C (PKC), a critical enzyme family involved in signal transduction pathways. This peptide has garnered significant attention in biochemical and pharmacological research due to its ability to modulate PKC activity, making it a valuable tool for studying cellular processes such as proliferation, differentiation, and apoptosis. Researchers frequently search for terms like "PKC inhibitor peptides", "CAS 121545-65-1 applications", and "Protein Kinase C 19-31 mechanism", reflecting its relevance in modern scientific inquiry.

Structurally, Protein Kinase C (19-31) corresponds to residues 19 to 31 of the pseudosubstrate region of PKCα. This region plays a pivotal role in autoinhibition, preventing uncontrolled kinase activity. The peptide's sequence (RFARKGALRQKNV) is highly conserved across PKC isoforms, underscoring its functional importance. Recent studies have explored its potential in targeting PKC-related diseases, including cancer and neurological disorders, aligning with trending topics like "precision medicine" and "peptide-based therapeutics". Its CAS No. 121545-65-1 is often cited in patent filings and academic papers, emphasizing its commercial and research value.

One of the most searched questions about Protein Kinase C (19-31) is: "How does PKC (19-31) inhibit enzyme activity?" The answer lies in its competitive binding to the substrate recognition site of PKC, effectively blocking interactions with downstream targets. This mechanism has inspired investigations into peptide mimetics and drug design, particularly for conditions like diabetic complications and cardiovascular diseases. Additionally, the peptide's stability and specificity make it a candidate for biomarker development, a hot topic in diagnostic innovation.

From a technical perspective, CAS No. 121545-65-1 is associated with high-purity synthetic peptides, often produced via solid-phase peptide synthesis (SPPS). Quality control metrics, such as HPLC purity (>95%) and mass spectrometry validation, are critical for ensuring reproducibility in experiments. Researchers also frequently inquire about "storage conditions for PKC (19-31)" and "solubility guidelines", highlighting practical concerns in handling this reagent. Proper storage at -20°C in lyophilized form is recommended to maintain stability.

Emerging trends in PKC research have linked Protein Kinase C (19-31) to immune regulation and neuroprotection, areas gaining traction in 2024. For instance, its role in modulating T-cell activation has implications for autoimmune therapies, while its neuroprotective effects are being explored in Alzheimer's disease models. These applications align with Google Scholar's rising keywords like "PKC and neurodegeneration" and "peptide inhibitors in immunology".

In summary, Protein Kinase C (19-31) (CAS No. 121545-65-1) represents a versatile research tool bridging fundamental biochemistry and translational medicine. Its well-characterized inhibitory mechanism, coupled with growing interest in targeted therapies, ensures its continued prominence in scientific literature. For laboratories focusing on kinase signaling or peptide drug discovery, this peptide remains an indispensable asset.

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