• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Estimation of fusel-oil in spirits
  Analyst, 1890,15, 203-209
• 3. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 4. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 5. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Comprehensive Overview of 3',5'-Dimethoxybiphenyl-3-carboxylic acid (CAS No. 1215205-86-9): Properties, Applications, and Research Insights

3',5'-Dimethoxybiphenyl-3-carboxylic acid (CAS No. 1215205-86-9) is a specialized organic compound belonging to the biphenyl carboxylic acid family. This compound features a unique structural framework with two methoxy groups (–OCH₃) positioned at the 3' and 5' locations of the biphenyl ring, coupled with a carboxylic acid (–COOH) functional group at the 3-position. Its molecular formula is C₁₅H₁₄O₄, and it exhibits a molecular weight of 258.27 g/mol. The compound's distinct aromatic and polar characteristics make it valuable in pharmaceutical intermediates, material science, and agrochemical research.

In recent years, 3',5'-Dimethoxybiphenyl-3-carboxylic acid has garnered attention due to its potential role in drug discovery and medicinal chemistry. Researchers are exploring its utility as a building block for small-molecule inhibitors and biologically active compounds, particularly in targeting enzymes like kinases or GPCRs. Its methoxy groups enhance solubility and bioavailability, aligning with the growing demand for optimized drug candidates in the pharmaceutical industry. Additionally, its biphenyl core is structurally analogous to several FDA-approved drugs, making it a promising scaffold for structure-activity relationship (SAR) studies.

From a synthetic chemistry perspective, CAS No. 1215205-86-9 serves as a versatile intermediate. Its carboxylic acid moiety allows for straightforward derivatization via esterification, amidation, or coupling reactions, enabling the creation of diverse chemical libraries. This adaptability is critical for high-throughput screening (HTS) campaigns in academic and industrial labs. Moreover, the compound's stability under ambient conditions facilitates its use in green chemistry applications, a trending topic in sustainable science.

The compound's relevance extends to material science, where its π-conjugated system contributes to optoelectronic properties. Researchers are investigating its incorporation into organic semiconductors or liquid crystals for display technologies. The dimethoxy substitution pattern may also influence charge transport efficiency, a key focus area for next-generation flexible electronics.

Analytical characterization of 3',5'-Dimethoxybiphenyl-3-carboxylic acid typically involves techniques like HPLC, NMR, and mass spectrometry. Purity thresholds (>95%) are crucial for research applications, driving demand for reliable reference standards. As regulatory agencies emphasize quality-by-design (QbD) principles, precise documentation of its physicochemical properties (e.g., melting point: ~150–155°C) becomes essential for compliance.

In summary, CAS No. 1215205-86-9 represents a multifaceted compound with cross-disciplinary applications. Its synergy with drug development, materials engineering, and synthetic methodology positions it as a compound of enduring scientific interest. Future studies may explore its structure-property relationships further, leveraging computational tools like molecular docking or DFT calculations to unlock new functionalities.

• 168618-45-9(3'-Methoxy1,1'-biphenyl-3-carboxylic Acid)
• 1261939-24-5(5-Methoxy-3-(4-methoxyphenyl)benzoic acid)
• 1261903-47-2(5-Hydroxy-3-(3-methoxyphenyl)benzoic acid)
• 5783-36-8(3'-methoxy-1,1'-biphenyl-4-carboxylic acid)
• 1261931-39-8(3-(4-Carboxyphenyl)-5-methoxybenzoic acid)
• 1261905-12-7(3-(3-Carboxyphenyl)-5-methoxybenzoic acid)
• 1261914-44-6(5-Methoxy-3-(3-methylphenyl)benzoic acid)
• 1261889-23-9(5-Methoxy-3-(4-methylphenyl)benzoic acid)
• 1261970-38-0(5-Methoxy-3-(3-methoxyphenyl)benzoic acid)
• 1215205-54-1(3'-Methoxy-5'-methylbiphenyl-3-carboxylic acid)