• 1. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 2. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Bipyridines and oligopyridines

Professional Introduction to 2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine (CAS No: 1214388-68-7)

2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine (CAS No: 1214388-68-7) is a highly specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and materials science. This compound, characterized by its brominated pyridine structure, serves as a crucial intermediate in the synthesis of various biologically active molecules. Its unique chemical architecture, featuring multiple pyridine rings and functional groups, makes it a valuable building block for developing novel therapeutic agents and advanced materials.

The compound's molecular structure consists of a central pyridine ring substituted with twopyridin-3-yl groups at the 3 and 5 positions, along with a bromine atom at the 2 position and a methyl group at the 4 position. This specific arrangement imparts distinct electronic and steric properties, making it particularly useful in cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings. These reactions are fundamental in constructing complex organic molecules, including those found in modern pharmaceuticals.

In recent years, the demand for high-quality intermediates like 2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine has surged due to advancements in drug discovery and material science. Researchers have leveraged its reactivity to develop new compounds with potential applications in treating various diseases. For instance, studies have shown that derivatives of this compound exhibit promising biological activities, including anti-inflammatory and anticancer properties. The ability to modify its structure allows chemists to fine-tune its properties, making it an indispensable tool in medicinal chemistry.

The synthesis of 2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine involves multi-step organic transformations that require precise control over reaction conditions. The bromination step is particularly critical, as it determines the compound's reactivity in subsequent synthetic steps. Recent innovations in catalytic systems have improved the efficiency and selectivity of these reactions, enabling higher yields and cleaner products. This progress underscores the importance of continuous research and development in optimizing synthetic pathways for such valuable intermediates.

One of the most compelling aspects of 2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine is its versatility in medicinal chemistry applications. Researchers have utilized it as a precursor for designing small molecule inhibitors targeting enzyme-driven diseases. For example, its framework has been employed to develop kinase inhibitors, which play a crucial role in cancer therapy. The presence of multiple reactive sites allows for diverse functionalization strategies, enabling the creation of structurally diverse libraries for high-throughput screening.

The compound's role extends beyond pharmaceuticals into materials science. Its unique electronic properties make it suitable for applications in organic electronics, including light-emitting diodes (OLEDs) and photovoltaic cells. By integrating 2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine into these systems, scientists can enhance device performance through tunable electron delocalization and charge transport properties. This dual utility highlights the compound's broad applicability across multiple scientific disciplines.

The latest research trends indicate that 2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine will continue to be a cornerstone in synthetic chemistry due to its adaptability and reactivity. Innovations in flow chemistry and green solvent systems are further streamlining its production process, making it more accessible to researchers worldwide. These advancements not only improve efficiency but also reduce environmental impact, aligning with global sustainability goals.

In conclusion, 2-Bromo-4-methyl-3,5-di(pyridin-3-yl)pyridine (CAS No: 1214388-68-7) is a multifaceted compound with significant implications in both pharmaceuticals and materials science. Its unique structural features and reactivity make it an invaluable intermediate for developing new drugs and advanced materials. As research progresses, we can expect even more innovative applications to emerge from this versatile chemical building block.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)