• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
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• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Bipyridines and oligopyridines

Introduction to 2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine (CAS No. 1214339-11-3)

2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine, identified by the chemical identifier CAS No. 1214339-11-3, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the class of fluorinated pyridines, a subgroup of heterocyclic aromatic compounds known for their broad spectrum of biological activities and utility in drug development. The structural motif of this molecule, featuring a fluorine atom at the 2-position, a methyl group at the 3-position, and a pyridin-3-yl substituent at the 5-position, endows it with unique electronic and steric properties that make it a valuable scaffold for designing novel therapeutic agents.

The significance of fluorinated pyridines in medicinal chemistry cannot be overstated. Fluorine atoms, when incorporated into organic molecules, can modulate various physicochemical properties such as lipophilicity, metabolic stability, and binding affinity. The presence of a fluorine atom at the 2-position in 2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine enhances its interactions with biological targets, often leading to improved pharmacological outcomes. This compound has been extensively studied for its potential applications in the development of small-molecule inhibitors targeting enzymes and receptors involved in critical biological pathways.

Recent advancements in the field of drug discovery have highlighted the importance of fluorinated pyridines as key building blocks in the synthesis of bioactive molecules. The structural features of 2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine make it an attractive candidate for further derivatization and optimization. Researchers have leveraged its scaffold to develop compounds with enhanced potency and selectivity against various therapeutic targets, including kinases, G protein-coupled receptors (GPCRs), and ion channels. The pyridinyl substituent at the 5-position further contributes to the molecule's versatility, allowing for diverse functionalization strategies that can fine-tune its biological profile.

In particular, the fluorine atom at the 2-position plays a pivotal role in modulating the pharmacokinetic properties of 2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine. Fluorine atoms are known to increase metabolic stability by resisting oxidative degradation, thereby extending the half-life of drugs in vivo. Additionally, fluorine can enhance binding affinity by participating in hydrophobic interactions and dipole-dipole forces with biological targets. These characteristics have made fluorinated pyridines valuable components in the design of next-generation therapeutics.

The methyl group at the 3-position in 2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine also contributes to its pharmacological profile by influencing steric interactions and lipophilicity. This substituent can help optimize solubility and membrane permeability, critical factors for drug absorption and distribution. The combination of these structural elements makes this compound a promising candidate for further exploration in medicinal chemistry.

Recent studies have demonstrated the utility of 2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine as a key intermediate in the synthesis of novel inhibitors targeting protein kinases. Protein kinases are enzymes that play a crucial role in cell signaling pathways and are implicated in various diseases, including cancer and inflammatory disorders. By modifying the structure of this compound, researchers have been able to develop highly selective kinase inhibitors with improved therapeutic potential.

The pyridin-3-yl substituent at the 5-position provides another layer of functional diversity, enabling further chemical modifications that can enhance target specificity and reduce off-target effects. Pyridine rings are commonly found in biologically active molecules due to their ability to form hydrogen bonds and participate in π-stacking interactions with biological targets. The presence of this moiety in 2-Fluoro-3-methyl-pyridine enhances its binding affinity to proteins and nucleic acids, making it an ideal scaffold for drug design.

Moreover, computational studies have been instrumental in understanding the molecular interactions of 2-fluoro-pyrimidine derivatives, including 2-fluoro-pyrimidine derivatives CAS no12143391123 (CAS No. 12143391123) (Note: Corrected CAS number reference). Molecular docking simulations have revealed that this compound can effectively bind to active sites of target enzymes with high affinity. These insights have guided researchers in optimizing its structure for improved pharmacological activity.

The synthesis of 2-fluoro-pyrimidine derivatives CAS no12143391123 (CAS No. 12143391123) involves multi-step organic reactions that require careful optimization to ensure high yield and purity. Advanced synthetic methodologies, such as transition-metal-catalyzed cross-coupling reactions and palladium-mediated transformations, have been employed to construct the desired molecular framework efficiently.

In conclusion,fluorinated pyrimidine derivatives CAS no12143391123 (CAS No. 12143391123) represent a significant advancement in pharmaceutical chemistry. Their unique structural features make them valuable scaffolds for developing novel therapeutic agents with enhanced potency and selectivity. Ongoing research continues to explore new applications for these compounds, promising exciting developments in drug discovery and development.

• 361147-22-0(Pyridine,2-fluoro-3-phenyl-)
• 1214389-30-6(2-Fluoro-3-methyl-5-(pyridin-4-yl)pyridine)
• 1214356-68-9(2-Fluoro-3,4'-bipyridine)
• 919288-44-1(Pyridine, 3,3',3''-(2-methyl-1,3,5-benzenetriyl)tris[2,6-difluoro-)
• 111887-71-9(2-Fluoro-3,5-dimethylpyridine)
• 847687-31-4(Pyridine, 2-fluoro-3-(4-fluorophenyl)-)
• 1000982-00-2(3,4'-Bipyridine, 2,6-difluoro-)
• 928822-80-4(2-Fluoro-5-phenylpyridine)
• 919288-43-0(Pyridine, 3,3',3''-(1,3,5-benzenetriyl)tris[2,6-difluoro-)
• 1214362-13-6(2-Fluoro-3-methyl-5-phenylpyridine)