Production Method 1

1489-53-8

121219-07-6

946078-87-1

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Toluene ;  5 - 6 h, 50 °C

Reference

Method for preparing difluorophenyl alkyl ether from 1,2,3-trifluorobenzene

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2,3-Difluoroethoxybenzene Raw materials

• 1,2,3-Trifluorobenzene

2,3-Difluoroethoxybenzene Preparation Products

• 2,3-Difluoroethoxybenzene (121219-07-6)
• 2-Ethoxy-1,3-difluorobenzene (946078-87-1)

• 1. Advanced liquid crystals for television
  Detlef Pauluth,Kazuaki Tarumi J. Mater. Chem. 2004 14 1219

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

2,3-Difluoroethoxybenzene (CAS No. 121219-07-6): A Comprehensive Overview

2,3-Difluoroethoxybenzene, identified by the CAS registry number 121219-07-6, is a chemical compound that has garnered significant attention in recent years due to its unique properties and potential applications in various fields. This compound is an ether derivative with a benzene ring substituted by a difluoroethoxy group at the 2 and 3 positions. Its molecular formula is C₈H₅F₂O, and it exhibits a molecular weight of approximately 166.04 g/mol.

The synthesis of 2,3-difluoroethoxybenzene involves several methods, including nucleophilic aromatic substitution and coupling reactions. Recent advancements in catalytic systems have enabled more efficient and selective syntheses of this compound. For instance, researchers have explored the use of palladium catalysts to facilitate Suzuki-Miyaura coupling reactions, which have proven to be highly effective in constructing the desired ether linkages.

In terms of physical properties, 2,3-difluoroethoxybenzene is a crystalline solid at room temperature with a melting point of around 55°C and a boiling point of approximately 185°C under standard conditions. Its solubility in common organic solvents such as dichloromethane and ethyl acetate is moderate, making it suitable for various chemical transformations. The compound also exhibits moderate stability under normal storage conditions but may degrade under harsh acidic or basic conditions.

The chemical structure of 2,3-difluoroethoxybenzene endows it with unique electronic properties. The fluorine atoms at the ortho positions introduce electron-withdrawing effects, which influence the reactivity of the benzene ring. This makes the compound an interesting candidate for applications in materials science, particularly in the development of advanced polymers and composites. Recent studies have demonstrated its potential as a building block for high-performance polymer electrolytes in lithium-ion batteries.

In addition to its role in materials science, 2,3-difluoroethoxybenzene has shown promise in pharmaceutical research. Its structure allows for further functionalization to create bioactive molecules with potential therapeutic applications. For example, researchers have explored its use as an intermediate in the synthesis of novel kinase inhibitors and other drug candidates.

The environmental impact of 2,3-difluoroethoxybenzene has also been a topic of recent investigation. Studies suggest that the compound undergoes biodegradation under specific environmental conditions, though its persistence in certain ecosystems remains a concern. Regulatory agencies are increasingly focusing on assessing the long-term effects of such compounds on aquatic and terrestrial ecosystems.

In conclusion, 2,3-difluoroethoxybenzene (CAS No. 121219-07-6) is a versatile compound with diverse applications across multiple disciplines. Its unique chemical properties and recent advancements in synthesis techniques continue to drive innovation in materials science, pharmaceuticals, and environmental chemistry. As research progresses, this compound is expected to play an even more significant role in addressing challenges in these fields.

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