Cas no 1211520-73-8 (4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine)
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine is a heterocyclic compound featuring a pyrrolo[2,3-d]pyrimidine core substituted with a chloro group at the 4-position and a trifluoromethyl group at the 5-position. This structure imparts unique electronic and steric properties, making it a valuable intermediate in medicinal chemistry and pharmaceutical research. The presence of the trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro group provides a reactive site for further functionalization. This compound is particularly useful in the synthesis of kinase inhibitors and other bioactive molecules targeting various disease pathways. Its high purity and well-defined reactivity profile ensure reliable performance in complex synthetic applications.
![4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine structure](https://ossimg.kuujia.com/scimg/1212000/1211520-73-8x500.png)
1211520-73-8 structure
Product Name:4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS No:1211520-73-8
MF:C7H3ClF3N3
MW:221.567030191422
MDL:MFCD18254703
CID:4456916
PubChem ID:72207277
Update Time:2025-07-02
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine Chemical and Physical Properties
Names and Identifiers
-
- 4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine
- 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-(trifluoromethyl)-
- 4-chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-d]pyrimidine
- AKOS025290752
- SY098394
- DB-412550
- CS-0050924
- AS-34800
- PB11660
- MFCD18254703
- 1211520-73-8
- SCHEMBL16108927
-
- MDL： MFCD18254703
- Inchi： 1S/C7H3ClF3N3/c8-5-4-3(7(9,10)11)1-12-6(4)14-2-13-5/h1-2H,(H,12,13,14)
- InChI Key： XTQGBMSLTHSCEX-UHFFFAOYSA-N
- SMILES： ClC1=C2C(=NC=N1)NC=C2C(F)(F)F
Computed Properties
- Exact Mass: 220.9967593g/mol
- Monoisotopic Mass: 220.9967593g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 14
- Rotatable Bond Count: 0
- Complexity: 223
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.5
- Topological Polar Surface Area: 41.6?2
Experimental Properties
- Density: 1.7±0.1 g/cm3
- Melting Point: Not available
- Boiling Point: Not available
- Flash Point: Not available
- Vapor Pressure: Not available
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | C597428-2.5mg |
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 2.5mg |
$ 50.00 | 2022-06-06 | ||
| TRC | C597428-5mg |
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 5mg |
$ 70.00 | 2022-06-06 | ||
| TRC | C597428-25mg |
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 25mg |
$ 230.00 | 2022-06-06 | ||
| Alichem | A089006093-250mg |
4-Chloro-5-(trifluoromethyl)-7h-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 95% | 250mg |
$719.28 | 2023-09-04 | |
| Alichem | A089006093-1g |
4-Chloro-5-(trifluoromethyl)-7h-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 95% | 1g |
$1665.00 | 2023-09-04 | |
| Chemenu | CM106041-100mg |
4-chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 95%+ | 100mg |
$660 | 2021-08-06 | |
| Chemenu | CM106041-250mg |
4-chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 95%+ | 250mg |
$1106 | 2021-08-06 | |
| Chemenu | CM106041-500mg |
4-chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 95%+ | 500mg |
$748 | 2022-06-14 | |
| Chemenu | CM106041-5g |
4-chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 95%+ | 5g |
$3203 | 2022-06-14 | |
| Chemenu | CM106041-10g |
4-chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine |
1211520-73-8 | 95%+ | 10g |
$5339 | 2022-06-14 |
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine Related Literature
-
Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
-
Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
-
Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
-
Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
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